About   Help   FAQ
Urod
Gene Detail
 Symbol
Name
ID
Urod
uroporphyrinogen decarboxylase
MGI:98916
Synonyms Uro-d
Feature Type protein coding gene
Genetic Map
Chromosome 4
53.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr4:116989965-116994413 bp, - strand
From VEGA annotation of GRCm38

  4449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: uroporphyrinogen-III decarboxylase/methylcobamide:CoM methyltransferase
Gene Tree: Urod

Human
homologs
Human Homolog UROD, uroporphyrinogen decarboxylase
NCBI Gene ID 7389
neXtProt AC  NX_P06132
Human Synonyms  PCT, UPD
Human Chr (Location)  1p34; chr1:45012133-45015669 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human UROD
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this loci results in embryonic lethality. Though heterozygous mutant mice are overtly normal, they are susceptible to hepatic iron loading and porphyria.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Urod interacts with 70 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process heme biosynthetic process, heme metabolic process, ...
Component cytoplasm, cytosol
Function carboxy-lyase activity, ferrous iron binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (187)    Tissues (103)    Images (34)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 187
cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) Genomic(1) cDNA(124)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000009782 (Evidence)
Ensembl Gene ModelENSMUSG00000028684 (Evidence)
Entrez Gene22275 (Evidence)
UniGene46484
DFCITC1574840, TC1687877
DoTSDT.101407693, DT.536206, DT.55119063, DT.99860627
NIA Mouse Gene IndexU025423
EC4.1.1.37
Consensus CDS ProjectCCDS18521.1
International Mouse Knockout Project StatusUrod
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009782 VEGA Gene Model | MGI Sequence Detail 4449 C57BL/6J ±  kb
transcript OTTMUST00000022649 VEGA | MGI Sequence Detail 1489 Not Applicable 
polypeptide OTTMUSP00000010340 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006361 Uroporphyrinogen decarboxylase HemE
InterPro IPR000257 Uroporphyrinogen decarboxylase (URO-D)
Protein Ontology PR:000017134 uroporphyrinogen decarboxylase
References (Earliest) J:14642 Romana M, et al., Rat uroporphyrinogen decarboxylase cDNA: nucleotide sequence and comparison to human uroporphyrinogen decarboxylase. Nucleic Acids Res. 1987 Sep 11;15(17):7211
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)
Other
accession IDs
MGD-MRK-15372, MGI:2140235

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory