Upk3a
Gene Detail

Symbol Name ID

Upk3a uroplakin 3A MGI:98914

Synonyms

1110017C07Rik, Upk3

Feature Type

protein coding gene

Genetic Map

Chromosome 15

40.25 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:85017141-85022560 bp, + strand From NCBI annotation of GRCm38   5420 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Upk3a

Human homologs

Human Homolog		UPK3A, uroplakin 3A
NCBI Gene ID		7380
neXtProt AC		NX_O75631
Human Synonyms		UP3A, UPIII, UPIIIA, UPK3
Human Chr (Location)		22q13.31; chr22:45680868-45691755 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UPK3A

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice exhibit urogenital defects including abnormal urothelium, vesicoureteral reflux, and hydronephrosis.

 
Human Diseases Modeled Using Mouse Upk3a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell morphogenesis, epithelial cell differentiation, ...
Component	apical plasma membrane, endoplasmic reticulum, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (142)    Tissues (108)    Images (35)
Theiler Stages: 11, 12, 17, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	129
RT-PCR	9

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(10) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022435 (Evidence)
Entrez Gene	22270 (Evidence)
UniGene	46214
DFCI	TC1600934
DoTS	DT.50315257
NIA Mouse Gene Index	U016514
Consensus CDS Project	CCDS27716.1
International Mouse Knockout Project Status	Upk3a

Sequences

Length	Strain/Species
genomic	22270	NCBI Gene Model | MGI Sequence Detail	5420	C57BL/6J
transcript	NM_023478	RefSeq | MGI Sequence Detail	1106	C57BL/6
polypeptide	Q9JKX8	UniProt | EBI | MGI Sequence Detail	287	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024831	Uroplakin-3
InterPro	IPR024825	Uroplakin-3a
Protein Ontology	PR:000017115	uroplakin-3A

Graphical View of Protein Domain Structure

References

(Earliest) J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
(Latest) J:190886 Morimoto M, et al., Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development. 2012 Dec 1;139(23):4365-73
All references(49)

Other accession IDs

MGD-MRK-15369, MGI:1915869