About   Help   FAQ
Upk3a
Gene Detail
Symbol

Name
ID
Upk3a
uroplakin 3A
MGI:98914
Synonyms
1110017C07Rik, Upk3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
40.25 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:85017141-85022560 bp, + strand
From NCBI annotation of GRCm38

  5420 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Upk3a

Human
homologs
Human Homolog UPK3A, uroplakin 3A
NCBI Gene ID 7380
neXtProt AC  NX_O75631
Human Synonyms  UP3A, UPIII, UPIIIA, UPK3
Human Chr (Location)  22q13.31; chr22:45284987-45295874 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Upk3a (1)
Incidental mutations (data from APF )
 
Homozygous null mice exhibit urogenital defects including abnormal urothelium, vesicoureteral reflux, and hydronephrosis.
 
Human Diseases Modeled Using Mouse Upk3a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Upk3a interacts with 29 markers (Mir27a, Mir27b, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell morphogenesis, epithelial cell differentiation, ...
Component apical plasma membrane, endoplasmic reticulum, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (223)    Tissues (187)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 210
RT-PCR 9
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022435 (Evidence)
Entrez Gene22270 (Evidence)
UniGene46214
DFCITC1600934
DoTSDT.50315257
NIA Mouse Gene IndexU016514
Consensus CDS ProjectCCDS27716.1
International Mouse Knockout Project StatusUpk3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22270 NCBI Gene Model | MGI Sequence Detail 5420 C57BL/6J ±  kb
transcript NM_023478 RefSeq | MGI Sequence Detail 1106 C57BL/6 
polypeptide Q9JKX8 UniProt | EBI | MGI Sequence Detail 287 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024831 Uroplakin-3
InterPro IPR024825 Uroplakin-3a
Protein Ontology PR:000017115 uroplakin-3a
Graphical View of Protein Domain Structure
References
(Earliest) J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
(Latest) J:210128 Weiss RM, et al., Brg1 determines urothelial cell fate during ureter development. J Am Soc Nephrol. 2013 Mar;24(4):618-26
All references(54)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15369, MGI:1915869

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory