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Upk3a Gene Detail
Summary
  • Symbol
    Upk3a
  • Name
    uroplakin 3A
  • Synonyms
    1110017C07Rik, Upk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98914
    NCBI Gene: 22270
  • Gene Overview
    MyGene.info: UPK3A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:85017141-85022547 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 40.25 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98914
protein coding gene Chr15:85017141-85022560 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022186
protein coding gene Chr15:85836442-85841861 (+)
A/J MGP_AJ_G0022145
protein coding gene Chr15:82669470-82674889 (+)
AKR/J MGP_AKRJ_G0022120
protein coding gene Chr15:85112487-85117909 (+)
BALB/cJ MGP_BALBcJ_G0022151
protein coding gene Chr15:82792984-82798403 (+)
C3H/HeJ MGP_C3HHeJ_G0021921
protein coding gene Chr15:85042051-85047470 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022596
protein coding gene Chr15:89097986-89103405 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020121
protein coding gene Chr15:79016097-79021592 (+)
CAST/EiJ MGP_CASTEiJ_G0021443
protein coding gene Chr15:85820910-85842973 (+)
CBA/J MGP_CBAJ_G0021888
protein coding gene Chr15:91994267-91999686 (+)
DBA/2J MGP_DBA2J_G0022015
protein coding gene Chr15:82139646-82144874 (+)
FVB/NJ MGP_FVBNJ_G0021994
protein coding gene Chr15:81211324-81216743 (+)
LP/J MGP_LPJ_G0022086
protein coding gene Chr15:85999537-86004956 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022014
protein coding gene Chr15:96773472-96778894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022611
protein coding gene Chr15:85105040-85110459 (+)
PWK/PhJ MGP_PWKPhJ_G0021184
protein coding gene Chr15:82146968-82152202 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021018
protein coding gene Chr15:84813153-84818580 (+)
WSB/EiJ MGP_WSBEiJ_G0021492
protein coding gene Chr15:85599667-85604895 (+)



Homology
more
  • Human Ortholog
    UPK3A, uroplakin 3A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    UPK3A, uroplakin 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UP3A, UPIII, UPIIIA, UPK3
  • Links
    NCBI Gene ID: 7380
    neXtProt AC: NX_O75631
    UniProt: O75631

  • Chr Location
    22q13.31; chr22:45284987-45295874 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Upk3a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit urogenital defects including abnormal urothelium, vesicoureteral reflux, and hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022435 Ensembl Gene Model | MGI Sequence Detail 5407 C57BL/6J ±  kb
    transcript ENSMUST00000023070 Ensembl | MGI Sequence Detail 1093 Not Applicable  
    polypeptide ENSMUSP00000023070 Ensembl | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15369, MGI:1915869
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 36
      Diseases 2
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:294193 Jones LK, et al., A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder. Development. 2020 Jun 22;147(21)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/23/2021
    MGI 6.16
    The Jackson Laboratory