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Upk3a
Gene Detail
Symbol

Name
ID
Upk3a
uroplakin 3A
MGI:98914
Synonyms
1110017C07Rik, Upk3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
40.25 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:85017141-85022560 bp, + strand
From NCBI annotation of GRCm38

  5420 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: UPK3A
Gene Tree: Upk3a

Human
homologs
UPK3A, uroplakin 3A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7380
neXtProt AC: NX_O75631

Human Synonyms: UP3A, UPIII, UPIIIA, UPK3

Human Chr (Location): 22q13.31; chr22:45284987-45295879 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Upk3a (1)
Incidental mutations (data from APF )
 
Homozygous null mice exhibit urogenital defects including abnormal urothelium, vesicoureteral reflux, and hydronephrosis.
 
Human Diseases Modeled in Mice Using Upk3a (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(7)
Interactions
Upk3a interacts with 29 markers (Mir27a, Mir27b, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell morphogenesis, epithelial cell differentiation, ...
Component apical plasma membrane, endoplasmic reticulum, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (221)    Tissues (185)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 208
RT-PCR 9
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase upk3a    NEW 
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022435 (Evidence)
Entrez Gene 22270 (Evidence)
UniGene 46214
DFCI TC1600934
DoTS DT.50315257
NIA Mouse Gene Index U016514
Consensus CDS Project CCDS27716.1
International Mouse Phenotyping Consortium Status Upk3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22270 NCBI Gene Model | MGI Sequence Detail 5420 C57BL/6J ±  kb
transcript NM_023478 RefSeq | MGI Sequence Detail 1106 C57BL/6 
polypeptide Q9JKX8 UniProt | EBI | MGI Sequence Detail 287 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024831 Uroplakin-3
InterPro IPR024825 Uroplakin-3a
Protein Ontology PR:000017115 uroplakin-3a
Graphical View of Protein Domain Structure
References
(Earliest) J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
(Latest) J:220499 Vieira N, et al., SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells. PLoS One. 2014;9(6):e99644
All references(53)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15369, MGI:1915869

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory