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Upk3a Gene Detail
Summary
  • Symbol
    Upk3a
  • Name
    uroplakin 3A
  • Synonyms
    1110017C07Rik, Upk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98914
    NCBI Gene: 22270
  • Gene Overview
    MyGene.info: UPK3A
Location & Maps
more
  • Sequence Map
    Chr15:85017141-85022560 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5420 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 40.25 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UPK3A, uroplakin 3A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    UPK3A, uroplakin 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UP3A, UPIII, UPIIIA, UPK3
  • Links
    NCBI Gene ID: 7380
    neXtProt AC: NX_O75631

  • Chr Location
    22q13.31; chr22:45284987-45295879 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Upk3a mouse models

Human Disease Mouse Models
       Vesicoureteral Reflux 1; VUR1   OMIM: 193000 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Upk3a
  • Incidental Mutations
    APF
Homozygous null mice exhibit urogenital defects including abnormal urothelium, vesicoureteral reflux, and hydronephrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22270 NCBI Gene Model | MGI Sequence Detail 5420 C57BL/6J ±  kb
transcript NM_023478 RefSeq | MGI Sequence Detail 1106 C57BL/6  
polypeptide Q9JKX8 UniProt | EBI | MGI Sequence Detail 287 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    98 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 11
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15369, MGI:1915869
References
more
  • Summaries
    All 53
    Developmental Gene Expression 25
    Diseases 2
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
  • Latest
    J:226950 Fogelgren B, et al., Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions. PLoS One. 2015;10(6):e0129346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory