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Upk2 Gene Detail
Summary
  • Symbol
    Upk2
  • Name
    uroplakin 2
  • Synonyms
    UPII, uroplakin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:98913
    NCBI Gene: 22269
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44364012-44366064 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98913
 protein coding gene Chr9:44364012-44366273 (-)
129S1/SvImJ ENSMUSG00200018316
 protein coding gene Chr9:41441436-41443713 (-)
A/J ENSMUSG00195023425
 protein coding gene Chr9:41186578-41188839 (-)
AKR/J ENSMUSG00220038240
 protein coding gene Chr9:41280775-41283036 (-)
BALB/cJ ENSMUSG00180025588
 protein coding gene Chr9:41298300-41300561 (-)
C3H/HeJ ENSMUSG00175014480
 protein coding gene Chr9:41309993-41312254 (-)
C57BL/6NJ ENSMUSG00215033049
 protein coding gene Chr9:41284280-41286541 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032119
 protein coding gene Chr9:41330396-41332452 (-)
CAST/EiJ ENSTCUG00005015047
 protein coding gene Chr9:41269906-41272150 (-)
CBA/J ENSMUSG00210016540
 protein coding gene Chr9:41363803-41366064 (-)
DBA/2J ENSMUSG00185009064
 protein coding gene Chr9:41424939-41427200 (-)
FVB/NJ ENSMUSG00205031512
 protein coding gene Chr9:41680227-41682488 (-)
JF1/MsJ ENSUMUG00000015707
 protein coding gene Chr9:41481059-41483336 (-)
LP/J ENSMUSG00230035720
 protein coding gene Chr9:41731910-41734146 (-)
NOD/ShiLtJ ENSMUSG00190020709
 protein coding gene Chr9:41503881-41506142 (-)
NZO/HlLtJ ENSMUSG00225043989
 protein coding gene Chr9:41684700-41686961 (-)
PWK/PhJ ENSLUMG00010018559
 protein coding gene Chr9:41441594-41443871 (-)
SPRET/EiJ ENSMSPG00010008814
 protein coding gene Chr9:42203177-42205453 (-)
WSB/EiJ ENSIUOG00005019100
 protein coding gene Chr9:40917550-40919811 (-)



Homology
more
  • Human Ortholog
    UPK2, uroplakin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPK2, uroplakin 2
  • Synonyms
    UP2, UPII
  • Links
    NCBI Gene ID: 7379
    UniProt: O00526

  • Chr Location
    11q23.3; chr11:118925164-118958559 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    4 images
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal urothelium that lacks umbrella cells, hydronephrosis, partial or complete ureter obstruction, increased vesicoureteral reflux, increased blood urea nitrogen levels, polyuria, and partial postnatal lethality with growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    33
  • cDNA Data
    6
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22269 NCBI Gene Model | MGI Sequence Detail 2053 C57BL/6J ±  kb
    transcript NM_009476 RefSeq | MGI Sequence Detail 890 ZRU/MplStud  
    polypeptide P38575 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 7
      Primer pair 3
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15368, MGI:2143308
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 2
    • Earliest
      J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory