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Upk1b
Gene Detail
 Symbol
Name
ID
Upk1b
uroplakin 1B
MGI:98912
Synonyms Tspan20, Upk1
Feature Type protein coding gene
Genetic Map
Chromosome 16
26.87 cM, cytoband B5-C2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:38773184-38800203 bp, - strand
From NCBI annotation of GRCm38

  27020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5065  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Upk1b

Human
homologs
Human Homolog UPK1B, uroplakin 1B
NCBI Gene ID 7348
neXtProt AC  NX_O75841
Human Synonyms  TSPAN20, UPIB, UPK1
Human Chr (Location)  3q13.32; chr3:119173578-119205153 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous for a reporter allele are viable, fertile, and physically and behaviorally normal.
 
Interactions
Upk1b interacts with 106 markers (Mir7-1, Mir23b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process epithelial cell differentiation
Component apical plasma membrane, extracellular vesicular exosome, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (280)    Tissues (149)    Images (31)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26
Assay TypeResults
Immunohistochemistry 2
RNA in situ 266
RT-PCR 12
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(15) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000049436 (Evidence)
Entrez Gene22268 (Evidence)
UniGene130793
DFCITC1583079
DoTSDT.97336888
NIA Mouse Gene IndexU037041
Consensus CDS ProjectCCDS28174.1
International Mouse Knockout Project StatusUpk1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22268 NCBI Gene Model | MGI Sequence Detail 27020 C57BL/6J ±  kb
transcript NM_178924 RefSeq | MGI Sequence Detail 1769 C57BL/6 
polypeptide Q9Z2C6 UniProt | EBI | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000017113 uroplakin-1b
Graphical View of Protein Domain Structure
References (Earliest) J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
(Latest) J:204539 Gandhi D, et al., Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Dev Cell. 2013 Sep 16;26(5):469-82
All references(42)
Other
accession IDs
MGD-MRK-15365, MGD-MRK-15367, MGI:2146422

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory