Upk1a MGI Mouse Gene Detail - MGI:98911

Symbol

Upk1a
Name

uroplakin 1A
Synonyms

1110031P12Rik, Tspan21, Upk1

Feature Type

protein coding gene
IDs

MGI:98911
NCBI Gene: 109637
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:30302517-30312159 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 18.78 cM
Mapping Data

8 experiments

SNPs within 2kb

397 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98911	protein coding gene	Chr7:30302517-30312272 (-)
129S1/SvImJ	ENSMUSG00200023311	protein coding gene	Chr7:20082744-20092520 (-)
A/J	ENSMUSG00195035750	protein coding gene	Chr7:22751411-22761242 (-)
AKR/J	ENSMUSG00220053244	protein coding gene	Chr7:21720025-21729857 (+)
BALB/cJ	ENSMUSG00180015474	protein coding gene	Chr7:20810891-20820726 (-)
C3H/HeJ	ENSMUSG00175035922	protein coding gene	Chr7:21891552-21901312 (-)
C57BL/6NJ	ENSMUSG00215053231	protein coding gene	Chr7:19993676-20003438 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029533	protein coding gene	Chr7:29839695-29848971 (-)
CAST/EiJ	ENSTCUG00005042141	protein coding gene	Chr7:21792252-21802264 (-)
CBA/J	ENSMUSG00210024018	protein coding gene	Chr7:21054160-21063917 (-)
DBA/2J	ENSMUSG00185046273	protein coding gene	Chr7:24142250-24152127 (-)
FVB/NJ	ENSMUSG00205010309	protein coding gene	Chr7:20803172-20812929 (-)
JF1/MsJ	ENSUMUG00000055970	protein coding gene	Chr7:28587800-28597748 (-)
LP/J	ENSMUSG00230052138	protein coding gene	Chr7:29312697-29322559 (-)
NOD/ShiLtJ	ENSMUSG00190008044	protein coding gene	Chr7:20475799-20485600 (-)
NZO/HlLtJ	ENSMUSG00225026595	protein coding gene	Chr7:28153097-28163040 (-)
PWK/PhJ	ENSLUMG00010018447	protein coding gene	Chr7:20519252-20529244 (-)
SPRET/EiJ	ENSMSPG00010038485	protein coding gene	Chr7:19881285-19890971 (-)
WSB/EiJ	ENSIUOG00005048451	protein coding gene	Chr7:14764507-14774312 (-)

Human Ortholog

UPK1A, uroplakin 1A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UPK1A, uroplakin 1A
Synonyms

TSPAN21, UP1A, UPIA, UPKA
Links

HGNC:12577

NCBI Gene ID: 11045

UniProt: O00322
Chr Location

19q13.12; chr19:35666517-35678481 (+) GRCh38

MGI Vertebrate Homology

Upk1a stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: UPK1A
Protein SuperFamily

Tetraspanin
Gene Tree

Upk1a

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Phenotype Summary

42 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

4
Gene trapped

27
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele show a marginal reduction in fecundity associated with oligozoospermia, various histopathological changes in the male reproductive tract tissues as well as in non-reproductive tissues, and a lower bacterial clearance capacity in response to uropathogenic E. coli infection.

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

669
Tissues

25
cDNA Data

10
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase upk1a

ZFIN upk1a

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS21103.1

Ensembl

ENSMUSG00000006313 (Evidence)
NCBI Gene

109637

			Length	Strain/Species	Flank
genomic	109637	NCBI Gene Model \| MGI Sequence Detail	9643	C57BL/6J	± kb
transcript	NM_026815	RefSeq \| MGI Sequence Detail	1308	ZRU/MplStud
polypeptide	Q9D132	UniProt \| EBI \| MGI Sequence Detail	257	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017112 uroplakin-1a

(term hierarchy)
InterPro Domains

IPR000301 Tetraspanin, animals

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

Q9D132 1 site

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All nucleic 16

cDNA 11

Primer pair 4

Other 1

Antibodies 3

Microarray probesets 3

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MGD-MRK-15365, MGD-MRK-15366, MGI:1915954, MGI:2142127, MGI:2142373

Summaries

All 52

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 8
Earliest

J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
Latest

J:372263 Jasmine, et al., Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities. Mucosal Immunol. 2025 Sep 2;

TSS for Upk1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71821	Chr7:30313286-30313290 (-)	-1,129 bp
Tssr71820	Chr7:30312222-30312306 (-)	-105 bp
Tssr71819	Chr7:30312186-30312196 (-)	-32 bp
Tssr71818	Chr7:30312156-30312169 (-)	-4 bp
Tssr71817	Chr7:30306351-30306367 (-)	5,800 bp
Tssr71816	Chr7:30304622-30304630 (-)	7,533 bp
Tssr71815	Chr7:30303228-30303237 (-)	8,926 bp
Tssr71814	Chr7:30303003-30303010 (-)	9,152 bp
Tssr71813	Chr7:30302984-30302990 (-)	9,172 bp
Tssr71812	Chr7:30302943-30302953 (-)	9,211 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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