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Pgc Gene Detail
Summary
  • Symbol
    Pgc
  • Name
    progastricsin (pepsinogen C)
  • Synonyms
    2210410L06Rik, Upg1, Upg-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98909
    NCBI Gene: 109820
  • Gene Overview
    MyGene.info: PGC
Location & Maps
more
  • Sequence Map
    Chr17:47726842-47734482 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7641 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PGC, progastricsin (pepsinogen C)
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PGC, progastricsin (pepsinogen C)
    Orthology source: HomoloGene
  • Synonyms
    PEPC, PGII
  • Links
    NCBI Gene ID: 5225
    neXtProt AC: NX_P20142

  • Chr Location
    6p21.1; chr6:41736711-41747401 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    14
  • Gene trapped
    12
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018356 VEGA Gene Model | MGI Sequence Detail 7641 C57BL/6J ±  kb
transcript OTTMUST00000044343 VEGA | MGI Sequence Detail 1388 Not Applicable  
polypeptide OTTMUSP00000019927 VEGA | MGI Sequence Detail 392 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    cDNA 87

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-15361, MGD-MRK-15363, MGI:1914363
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:6576 Szymura JM, et al., Linkage of a gene controlling urinary pepsinogen with the major histocompatibility complex of the mouse. Immunogenetics. 1981;13(3):267-71
  • Latest
    J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory