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Pgc
Gene Detail
 Symbol
Name
ID
Pgc
progastricsin (pepsinogen C)
MGI:98909
Synonyms 2210410L06Rik, Upg1, Upg-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
23.98 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr17:47726842-47734482 bp, + strand
From VEGA annotation of GRCm38

  7641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55669  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog

Protein SuperFamily: Pepsin
Gene Tree: Pgc

Human
homologs
Human Homolog PGC, progastricsin (pepsinogen C)
NCBI Gene ID 5225
neXtProt AC  NX_P20142
Human Synonyms  PEPC, PGII
Human Chr (Location)  6p21.1; chr6:41736711-41747401 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pgc interacts with 27 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process digestion, proteolysis
Component extracellular region, extracellular vesicular exosome
Function aspartic-type endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
cDNA source data(87)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(87)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000018356 (Evidence)
Ensembl Gene ModelENSMUSG00000023987 (Evidence)
Entrez Gene109820 (Evidence)
UniGene22957
DFCITC1572580
DoTSDT.50317168, DT.94352284
NIA Mouse Gene IndexU018068
EC3.4.23.3
Consensus CDS ProjectCCDS28855.1
International Mouse Knockout Project StatusPgc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018356 VEGA Gene Model | MGI Sequence Detail 7641 C57BL/6J ±  kb
transcript OTTMUST00000044343 VEGA | MGI Sequence Detail 1388 Not Applicable 
polypeptide OTTMUSP00000019927 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR001969 Peptidase aspartic, active site
InterPro IPR012848 Propeptide, peptidase A1
Protein Ontology PR:000012602 gastricsin
References (Earliest) J:6576 Szymura JM, et al., Linkage of a gene controlling urinary pepsinogen with the major histocompatibility complex of the mouse. Immunogenetics. 1981;13(3):267-71
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(60)
Other
accession IDs
MGD-MRK-15361, MGD-MRK-15363, MGI:1914363

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory