Pgc
Gene Detail

Symbol Name ID

Pgc progastricsin (pepsinogen C) MGI:98909

Synonyms

2210410L06Rik, Upg1, Upg-1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

23.98 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(29)

Sequence Map

Chr17:47726842-47734482 bp, + strand From VEGA annotation of GRCm38   7641 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55669  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken

Protein SuperFamily: Pepsin
Gene Tree: Pgc

Human homologs

Human Homolog		PGC, progastricsin (pepsinogen C)
NCBI Gene ID		5225
neXtProt AC		NX_P20142
Human Synonyms		PEPC, PGII
Human Chr (Location)		6p21.1; chr6:41704449-41715139 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(2) Gene trapped(12)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	digestion, proteolysis
Component	extracellular region, nucleus
Function	aspartic-type endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) cDNA(87)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000018356 (Evidence)
Ensembl Gene Model	ENSMUSG00000023987 (Evidence)
Entrez Gene	109820 (Evidence)
UniGene	22957
DFCI	TC1572580
DoTS	DT.50317168, DT.94352284
NIA Mouse Gene Index	U018068
EC	3.4.23.3
Consensus CDS Project	CCDS28855.1
International Mouse Knockout Project Status	Pgc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018356	VEGA Gene Model | MGI Sequence Detail	7641	C57BL/6J
transcript	OTTMUST00000044343	VEGA | MGI Sequence Detail	1388	Not Applicable
polypeptide	OTTMUSP00000019927	VEGA | MGI Sequence Detail	392	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(73 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR021109	Aspartic peptidase
InterPro	IPR001461	Peptidase A1
InterPro	IPR001969	Peptidase aspartic, active site
InterPro	IPR012848	Propeptide, peptidase A1
Protein Ontology	PR:000012602	gastricsin

References

(Earliest) J:6576 Szymura JM, et al., Linkage of a gene controlling urinary pepsinogen with the major histocompatibility complex of the mouse. Immunogenetics. 1981;13(3):267-71
(Latest) J:179732 Stringer EJ, et al., Cdx2 determines the fate of postnatal intestinal endoderm. Development. 2012 Feb;139(3):465-74
All references(59)

Other accession IDs

MGD-MRK-15361, MGD-MRK-15363, MGI:1914363