About   Help   FAQ
Usp4 Gene Detail
Summary
  • Symbol
    Usp4
  • Name
    ubiquitin specific peptidase 4 (proto-oncogene)
  • Synonyms
    F730026I20Rik, Unp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98905
    NCBI Gene: 22258
  • Gene Overview
    MyGene.info: USP4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108347853-108392545 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.25 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98905
protein coding gene Chr9:108347818-108392545 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035294
protein coding gene Chr9:110298364-110347534 (+)
A/J MGP_AJ_G0035273
protein coding gene Chr9:106258632-106303227 (+)
AKR/J MGP_AKRJ_G0035205
protein coding gene Chr9:108913156-108959620 (+)
BALB/cJ MGP_BALBcJ_G0035267
protein coding gene Chr9:105954790-105999562 (+)
C3H/HeJ MGP_C3HHeJ_G0034977
protein coding gene Chr9:109307293-109352630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035787
protein coding gene Chr9:113296986-113346070 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032685
protein coding gene Chr9:103688837-103735220 (+)
CAST/EiJ MGP_CASTEiJ_G0034288
protein coding gene Chr9:109278498-109323333 (+)
CBA/J MGP_CBAJ_G0034945
protein coding gene Chr9:117292290-117349124 (+)
DBA/2J MGP_DBA2J_G0035106
protein coding gene Chr9:105713300-105758952 (+)
FVB/NJ MGP_FVBNJ_G0035054
protein coding gene Chr9:104479697-104525441 (+)
LP/J MGP_LPJ_G0035182
protein coding gene Chr9:110497805-110544355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035093
protein coding gene Chr9:118877149-118923113 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035808
protein coding gene Chr9:109203149-109247371 (+)
PWK/PhJ MGP_PWKPhJ_G0033995
protein coding gene Chr9:106040977-106086841 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033830
protein coding gene Chr9:109249200-109300213 (+)
WSB/EiJ MGP_WSBEiJ_G0034409
protein coding gene Chr9:109079306-109127907 (+)



Homology
more
  • Human Ortholog
    USP4, ubiquitin specific peptidase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP4, ubiquitin specific peptidase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UNP, Unph
  • Links
    NCBI Gene ID: 7375
    neXtProt AC: NX_Q13107
    UniProt: Q13107

  • Chr Location
    3p21.31; chr3:49277144-49340103 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased irradiation-induced apoptosis, slow cellular growth, resistance to oncogenic transformation, and early cellular replicative senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032612 Ensembl Gene Model | MGI Sequence Detail 44693 C57BL/6J ±  kb
transcript ENSMUST00000035237 Ensembl | MGI Sequence Detail 3662 Not Applicable  
polypeptide ENSMUSP00000035237 Ensembl | MGI Sequence Detail 962 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 5
    cDNA 22
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15356, MGI:2444466
References
more
  • Summaries
    All 48
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:13201 Gupta K, et al., Unp, a mouse gene related to the tre oncogene. Oncogene. 1993 Aug;8(8):2307-10
  • Latest
    J:243432 Zhou F, et al., USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO J. 2017 Jun 01;36(11):1623-1639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/15/2019
MGI 6.14
The Jackson Laboratory