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Usp4 Gene Detail
Summary
  • Symbol
    Usp4
  • Name
    ubiquitin specific peptidase 4 (proto-oncogene)
  • Synonyms
    F730026I20Rik, Unp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98905
    NCBI Gene: 22258
  • Gene Overview
    MyGene.info: USP4
Location & Maps
more
  • Sequence Map
    Chr9:108347853-108392545 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44693 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.25 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    USP4, ubiquitin specific peptidase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP4, ubiquitin specific peptidase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    UNP, Unph
  • Links
    NCBI Gene ID: 7375
    neXtProt AC: NX_Q13107

  • Chr Location
    3p21.3; chr3:49277144-49340103 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    7
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased irradiation-induced apoptosis, slow cellular growth, resistance to oncogenic transformation, and early cellular replicative senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050819 VEGA Gene Model | MGI Sequence Detail 44693 C57BL/6J ±  kb
transcript OTTMUST00000128774 VEGA | MGI Sequence Detail 3662 Not Applicable  
polypeptide OTTMUSP00000069251 VEGA | MGI Sequence Detail 962 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    36 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • PDB
  • EC
  • InterPro Domains
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
    IPR028134 Ubiquitin carboxyl-terminal hydrolase USP4/12
    IPR028135 Ubiquitin-like domain, USP-type
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
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  • All nucleic 27
    Genomic 5
    cDNA 21
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15356, MGI:2444466
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:13201 Gupta K, et al., Unp, a mouse gene related to the tre oncogene. Oncogene. 1993 Aug;8(8):2307-10
  • Latest
    J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory