Ugt1a1
Gene Detail

Symbol Name ID

Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 MGI:98898

Synonyms

Gnt1, Udpgt-1a, UGT1A01, UgtBr1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr1:88211959-88218997 bp, + strand From VEGA annotation of GRCm38   7039 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 chicken; 13 zebrafish

Protein SuperFamily: glucuronosyltransferase
Gene Tree: Ugt1a1

Human homologs

Human Homolog		UGT1A1, UDP glucuronosyltransferase 1 family, polypeptide A1
NCBI Gene ID		54658
neXtProt AC		NX_P22309
Human Synonyms		BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Human Chr (Location)		2q37; chr2:234668919-234681945 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human UGT1A1

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	biphenyl catabolic process, flavone metabolic process, ...
Component	cytochrome complex, endoplasmic reticulum, ...
Function	enzyme binding, enzyme inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (132)    Tissues (97)    Images (18)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	132

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(1) cDNA(13) Other(2)

Other database links

VEGA Gene Model	OTTMUSG00000020815 (Evidence)
Ensembl Gene Model	ENSMUSG00000089960 (Evidence)
Entrez Gene	394436 (Evidence)
EC	2.4.1.17
Consensus CDS Project	CCDS15143.1
International Mouse Knockout Project Status	Ugt1a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020815	VEGA Gene Model | MGI Sequence Detail	7039	C57BL/6J
transcript	OTTMUST00000049223	VEGA | MGI Sequence Detail	2224	Not Applicable
polypeptide	OTTMUSP00000022767	VEGA | MGI Sequence Detail	535	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(7) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002213	UDP-glucuronosyl/UDP-glucosyltransferase
Protein Ontology	PR:000017048	UDP-glucuronosyltransferase 1-1

References

(Earliest) J:28920 Robertson JA, et al., Autoregulation plus positive and negative elements controlling transcription of genes in the [Ah] battery. Chemica Scripta. 1987;27A:83-7
(Latest) J:182805 Bortolussi G, et al., Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. FASEB J. 2012 Mar;26(3):1052-63
All references(41)

Other accession IDs

MGD-MRK-10210, MGD-MRK-15340, MGD-MRK-15345