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Ugt1a1
Gene Detail
 Symbol
Name
ID
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
MGI:98898
Synonyms Gnt1, Udpgt-1a, UGT1A01, UgtBr1
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr1:88211959-88218997 bp, + strand
From VEGA annotation of GRCm38

  7039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 2 chicken; 13 zebrafish

Protein SuperFamily: glucuronosyltransferase
Gene Tree: Ugt1a1

Human
homologs
Human Homolog UGT1A1, UDP glucuronosyltransferase 1 family, polypeptide A1
NCBI Gene ID 54658
neXtProt AC  NX_P22309
Human Synonyms  BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Human Chr (Location)  2q37; chr2:233760273-233773299 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human UGT1A1
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process biphenyl catabolic process, cellular glucuronidation, ...
Component cytochrome complex, endoplasmic reticulum, ...
Function enzyme binding, enzyme inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (132)    Tissues (97)    Images (18)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 132
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Other(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020815 (Evidence)
Ensembl Gene ModelENSMUSG00000089960 (Evidence)
Entrez Gene394436 (Evidence)
EC2.4.1.17
Consensus CDS ProjectCCDS15143.1
International Mouse Knockout Project StatusUgt1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020815 VEGA Gene Model | MGI Sequence Detail 7039 C57BL/6J ±  kb
transcript OTTMUST00000049223 VEGA | MGI Sequence Detail 2224 Not Applicable 
polypeptide OTTMUSP00000022767 VEGA | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms RFLP(7) : SNPs within 2kb(219 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
Protein Ontology PR:000017048 UDP-glucuronosyltransferase 1-1
References (Earliest) J:28920 Robertson JA, et al., Autoregulation plus positive and negative elements controlling transcription of genes in the [Ah] battery. Chemica Scripta. 1987;27A:83-7
(Latest) J:182805 Bortolussi G, et al., Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. FASEB J. 2012 Mar;26(3):1052-63
All references(41)
Other
accession IDs
MGD-MRK-10210, MGD-MRK-15340, MGD-MRK-15345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory