About   Help   FAQ
Ugt1a1 Gene Detail
Summary
  • Symbol
    Ugt1a1
  • Name
    UDP glucuronosyltransferase 1 family, polypeptide A1
  • Synonyms
    Gnt1, Udpgt-1a, UGT1A01, UgtBr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98898
    NCBI Gene: 394436
  • Member of
    Ugt1 cluster
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:88211959-88218997 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.55 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    216 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98898
protein coding gene Chr1:88211959-88220002 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016281
protein coding gene Chr1:89615505-89628377 (+)
A/J MGP_AJ_G0016263
protein coding gene Chr1:86324430-86329787 (+)
AKR/J MGP_AKRJ_G0016224
protein coding gene Chr1:88844882-88898479 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0016048
protein coding gene Chr1:89111961-89122337 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016678
protein coding gene Chr1:92988097-92996654 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014396
protein coding gene Chr1:80700823-80707867 (+)
CAST/EiJ MGP_CASTEiJ_G0015634
protein coding gene Chr1:88330079-88339172 (+)
CBA/J MGP_CBAJ_G0016024
protein coding gene Chr1:95981957-95995691 (+)
DBA/2J MGP_DBA2J_G0016127
protein coding gene Chr1:85561185-85575541 (+)
FVB/NJ MGP_FVBNJ_G0016126
protein coding gene Chr1:84649687-84658645 (+)
LP/J MGP_LPJ_G0016198
protein coding gene Chr1:90694553-90703609 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016151
protein coding gene Chr1:99336942-99344396 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0015418
protein coding gene Chr1:84925852-84935762 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015200
protein coding gene Chr1:87868928-87876017 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    UGT1A1, UDP glucuronosyltransferase family 1 member A1
  • Vertebrate Orthologs
    20
  • Human Ortholog
    UGT1A1, UDP glucuronosyltransferase family 1 member A1
    Orthology source: HomoloGene
  • Synonyms
    BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
  • Links
    NCBI Gene ID: 54658
    neXtProt AC: NX_P22309
    UniProt: P22309

  • Chr Location
    2q37.1; chr2:233760273-233773299 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human UGT1A1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000089960 Ensembl Gene Model | MGI Sequence Detail 7039 C57BL/6J ±  kb
transcript ENSMUST00000073049 Ensembl | MGI Sequence Detail 2224 Not Applicable  
polypeptide ENSMUSP00000072803 Ensembl | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 14
    Other 2
Other
Accession IDs
less
MGD-MRK-10210, MGD-MRK-15340, MGD-MRK-15345
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:243978 Hinds TD Jr, et al., Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARalpha. Am J Physiol Endocrinol Metab. 2017 Apr 01;312(4):E244-E252

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory