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Ugt1a1 Gene Detail
Summary
  • Symbol
    Ugt1a1
  • Name
    UDP glucuronosyltransferase 1 family, polypeptide A1
  • Synonyms
    Gnt1, Udpgt-1a, UGT1A01, UgtBr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98898
    NCBI Gene: 394436
  • Member of
    Ugt1 cluster
Location & Maps
more
  • Sequence Map
    Chr1:88211959-88218997 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7039 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.55 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    UGT1A1, UDP glucuronosyltransferase family 1 member A1
  • Vertebrate Orthologs
    20
  • Human Ortholog
    UGT1A1, UDP glucuronosyltransferase family 1 member A1
    Orthology source: HomoloGene
  • Synonyms
    BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
  • Links
    NCBI Gene ID: 54658
    neXtProt AC: NX_P22309

  • Chr Location
    2q37; chr2:233760273-233773299 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with human UGT1A1 associations

Human Disease Mouse Models
       Crigler-Najjar Syndrome, Type I   OMIM: 218800
Crigler-Najjar Syndrome, Type II   OMIM: 606785
Gilbert Syndrome   OMIM: 143500
Hyperbilirubinemia, Transient Familial Neonatal; HBLRTFN   OMIM: 237900
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    2 involving Ugt1a1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020815 VEGA Gene Model | MGI Sequence Detail 7039 C57BL/6J ±  kb
transcript OTTMUST00000049223 VEGA | MGI Sequence Detail 2224 Not Applicable  
polypeptide OTTMUSP00000022767 VEGA | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    216 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017048 UDP-glucuronosyltransferase 1-1
  • EC
  • InterPro Domains
    IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
Molecular
Reagents
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  • All nucleic 16
    Genomic 1
    cDNA 13
    Other 2
Other
Accession IDs
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MGD-MRK-10210, MGD-MRK-15340, MGD-MRK-15345
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:28920 Robertson JA, et al., Autoregulation plus positive and negative elements controlling transcription of genes in the [Ah] battery. Chemica Scripta. 1987;27A:83-7
  • Latest
    J:182805 Bortolussi G, et al., Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. FASEB J. 2012 Mar;26(3):1052-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory