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Ubc
Gene Detail
Symbol

Name
ID
Ubc
ubiquitin C
MGI:98889
Synonyms
2700054O04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
64.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:125385965-125390202 bp, - strand
From VEGA annotation of GRCm38

  4238 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Ubc

Human
homologs
Human Homolog UBC, ubiquitin C
NCBI Gene ID 7316
neXtProt AC  NX_P0CG48
Human Synonyms  HMG20
Human Chr (Location)  12q24.3; chr12:124911646-124915041 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
 
Homozygous null embryos die between E 12.5 and E14.5 most likely due to a severe defect in liver cell proliferation. Mutant MEFs exhibit reduced growth rates, premature senescence, increased apoptosis and delayed cell-cycle progression, and are hypersensitive to proteasome inhibitors and heat shock.
 
Interactions
Ubc interacts with 60 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process ubiquitin homeostasis
Component cell, cytoplasm, ...
Function poly(A) RNA binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (9)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 8
cDNA source data(18)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(19) Primer pair(2)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034016 VEGA Gene Model | MGI Sequence Detail 4238 C57BL/6J ±  kb
transcript OTTMUST00000085872 VEGA | MGI Sequence Detail 2618 Not Applicable 
polypeptide OTTMUSP00000046440 VEGA | MGI Sequence Detail 734 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(2) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
InterPro IPR019954 Ubiquitin conserved site
InterPro IPR019956 Ubiquitin subgroup
Protein Ontology PR:000016963 polyubiquitin-C
References
(Earliest) J:329 Board PG, et al., Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3. Genomics. 1992 Apr;12(4):639-42
(Latest) J:202639 Park H, et al., Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells. Biochem Biophys Res Commun. 2013 Jun 7;435(3):434-40
All references(45)
Other
accession IDs
MGD-MRK-15327, MGI:1924253, MGI:2140815

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory