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Ubc
Gene Detail
 Symbol
Name
ID
Ubc
ubiquitin C
MGI:98889
Synonyms 2700054O04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 5
64.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:125385965-125390202 bp, - strand
From VEGA annotation of GRCm38

  4238 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Ubc

Human
homologs
Human Homolog UBC, ubiquitin C
NCBI Gene ID 7316
Human Synonyms  HMG20
Human Chr (Location)  12q24.3; chr12:124911646-124915041 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
 
Homozygous null embryos die between E 12.5 and E14.5 most likely due to a severe defect in liver cell proliferation. Mutant MEFs exhibit reduced growth rates, premature senescence, increased apoptosis and delayed cell-cycle progression, and are hypersensitive to proteasome inhibitors and heat shock.
 
Interactions
Ubc interacts with 60 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process ubiquitin homeostasis
Component cell, cytoplasm, ...
Function poly(A) RNA binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (9)    Tissues (8)   
Theiler Stages: 14, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 1
RT-PCR 8
cDNA source data(18)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(19) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000034016 (Evidence)
Ensembl Gene ModelENSMUSG00000008348 (Evidence)
Entrez Gene22190 (Evidence)
DFCITC1573654, TC1596880, TC1610990, TC1781790
DoTSDT.101374396, DT.101374438, DT.101374455, DT.101374747, DT.101374806, DT.101374874, DT.91385612, DT.91567379, DT.94164333, DT.94213036, DT.94213108, DT.94213152
PDB2ZNV, 3A1Q, 3A9J, 3A9K, 3VHT
Consensus CDS ProjectCCDS19684.2
International Mouse Knockout Project StatusUbc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034016 VEGA Gene Model | MGI Sequence Detail 4238 C57BL/6J ±  kb
transcript OTTMUST00000085872 VEGA | MGI Sequence Detail 2618 Not Applicable 
polypeptide OTTMUSP00000046440 VEGA | MGI Sequence Detail 734 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(2) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
InterPro IPR019954 Ubiquitin conserved site
InterPro IPR019956 Ubiquitin subgroup
Protein Ontology PR:000016963 polyubiquitin-C
References (Earliest) J:329 Board PG, et al., Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3. Genomics. 1992 Apr;12(4):639-42
(Latest) J:202639 Park H, et al., Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells. Biochem Biophys Res Commun. 2013 Jun 7;435(3):434-40
All references(45)
Other
accession IDs
MGD-MRK-15327, MGI:1924253, MGI:2140815

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory