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Ubc
Gene Detail
Symbol

Name
ID
Ubc
ubiquitin C
MGI:98889
Synonyms
2700054O04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
64.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:125385965-125390202 bp, - strand
From VEGA annotation of GRCm38

  4238 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: UBC
Gene Tree: Ubc

Human
homologs
UBC, ubiquitin C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7316
neXtProt AC: NX_P0CG48

Human Synonyms: HMG20

Human Chr (Location): 12q24.3; chr12:124911645-124915041 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from CvDC )
 
Homozygous null embryos die between E 12.5 and E14.5 most likely due to a severe defect in liver cell proliferation. Mutant MEFs exhibit reduced growth rates, premature senescence, increased apoptosis and delayed cell-cycle progression, and are hypersensitive to proteasome inhibitors and heat shock.
 
Interactions
Ubc interacts with 60 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process ubiquitin homeostasis
Component cell, cytoplasm, ...
Function poly(A) RNA binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (9)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 8
cDNA source data(18)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase ubc ; ZFIN ubc    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(19) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000034016 (Evidence)
Ensembl Gene Model ENSMUSG00000008348 (Evidence)
Entrez Gene 22190 (Evidence)
DFCI TC1573654, TC1596880, TC1610990, TC1781790
DoTS DT.101374396, DT.101374438, DT.101374455, DT.101374747, DT.101374806, DT.101374874, DT.91385612, DT.91567379, DT.94164333, DT.94213036, DT.94213108, DT.94213152
PDB 2ZNV, 3A1Q, 3A9J, 3A9K, 3VHT, 3WWQ, 3WXG, 4NQL
Consensus CDS Project CCDS19684.2
International Mouse Phenotyping Consortium Status Ubc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034016 VEGA Gene Model | MGI Sequence Detail 4238 C57BL/6J ±  kb
transcript OTTMUST00000085872 VEGA | MGI Sequence Detail 2618 Not Applicable 
polypeptide OTTMUSP00000046440 VEGA | MGI Sequence Detail 734 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(2) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019956 Ubiquitin
InterPro IPR019954 Ubiquitin conserved site
InterPro IPR000626 Ubiquitin domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000016963 polyubiquitin-C
References
(Earliest) J:329 Board PG, et al., Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3. Genomics. 1992 Apr;12(4):639-42
(Latest) J:202639 Park H, et al., Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells. Biochem Biophys Res Commun. 2013 Jun 7;435(3):434-40
All references(45)
Other
accession IDs
MGD-MRK-15327, MGI:1924253, MGI:2140815

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory