Homozygous null embryos die between E 12.5 and E14.5 most likely due to a severe defect in liver cell proliferation. Mutant MEFs exhibit reduced growth rates, premature senescence, increased apoptosis and delayed cell-cycle progression, and are hypersensitive to proteasome inhibitors and heat shock.
|VEGA Gene Model||OTTMUSG00000034016 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000008348 (Evidence)|
|Entrez Gene||22190 (Evidence)|
|DFCI||TC1573654, TC1596880, TC1610990, TC1781790|
|DoTS||DT.101374396, DT.101374438, DT.101374455, DT.101374747, DT.101374806, DT.101374874, DT.91385612, DT.91567379, DT.94164333, DT.94213036, DT.94213108, DT.94213152|
|PDB||2ZNV, 3A1Q, 3A9J, 3A9K, 3VHT, 4NQL|
|Consensus CDS Project||CCDS19684.2|
|International Mouse Knockout Project Status||Ubc|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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