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Ubc Gene Detail
Summary
  • Symbol
    Ubc
  • Name
    ubiquitin C
  • Synonyms
    2700054O04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98889
    NCBI Gene: 22190
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:125463029-125467081 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 64.18 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98889
 protein coding gene Chr5:125463029-125467266 (-)
129S1/SvImJ ENSMUSG00200028369
 protein coding gene Chr5:119194119-119195647 (-)
A/J ENSMUSG00195009539
 protein coding gene Chr5:118715819-118717348 (-)
AKR/J ENSMUSG00220045217
 protein coding gene Chr5:118218886-118223123 (-)
BALB/cJ ENSMUSG00180031293
 protein coding gene Chr5:118830667-118832195 (-)
C3H/HeJ ENSMUSG00175021559
 protein coding gene Chr5:120824966-120829203 (-)
C57BL/6NJ ENSMUSG00215020708
 protein coding gene Chr5:118873869-118878333 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J ENSMUSG00210010205
 protein coding gene Chr5:119575920-119580157 (-)
DBA/2J ENSMUSG00185006472
 protein coding gene Chr5:122626996-122631233 (-)
FVB/NJ ENSMUSG00205027441
 protein coding gene Chr5:118501362-118502979 (-)
FVB/NJ ENSMUSGG00205054167
 protein coding gene Chr5:118503109-118503714 (-)
JF1/MsJ ENSUMUG00000016314
 protein coding gene Chr5:125495032-125499726 (-)
LP/J ENSMUSG00230040802
 protein coding gene Chr5:126715915-126717444 (-)
NOD/ShiLtJ ENSMUSG00190024232
 protein coding gene Chr5:118501324-118505561 (-)
NZO/HlLtJ ENSMUSG00225013341
 protein coding gene Chr5:134411163-134415401 (-)
PWK/PhJ ENSLUMG00010030905
 protein coding gene Chr5:117393490-117398639 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005017388
 protein coding gene Chr5:121207865-121212329 (-)



Homology
more
  • Human Ortholog
    UBC, ubiquitin C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBC, ubiquitin C
  • Synonyms
    HMG20
  • Links
    NCBI Gene ID: 7316
    UniProt: P0CG48

  • Chr Location
    12q24.31; chr12:124911604-124917368 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die between E 12.5 and E14.5 most likely due to a severe defect in liver cell proliferation. Mutant MEFs exhibit reduced growth rates, premature senescence, increased apoptosis and delayed cell-cycle progression, and are hypersensitive to proteasome inhibitors and heat shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    14
  • cDNA Data
    20
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22190 NCBI Gene Model | MGI Sequence Detail 4053 C57BL/6J ±  kb
    transcript NM_019639 RefSeq | MGI Sequence Detail 2424 ZRU/MplStud  
    polypeptide P0CG50 UniProt | EBI | MGI Sequence Detail 734 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 21
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15327, MGI:1924253, MGI:2140815
    References
    more
    • Summaries
      All 244
      Developmental Gene Expression 14
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:378415 Brewer KM, et al., Primary cilia and BBS4 are required for postnatal pituitary development. Dev Biol. 2026 Jan 7;532:20-31
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory