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Ubb
Gene Detail
Symbol

Name
ID
Ubb
ubiquitin B
MGI:98888
Synonyms
Ubb2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
38.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:62551171-62553213 bp, + strand
From VEGA annotation of GRCm38

  2043 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74981  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog

Gene Tree: Ubb

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix )
 
Targeted disruption of this gene results in progressive degeneration of hypothalamic neurons accompanied by impaired hypothalamic control of energy balance and adult-onset obesity. Both genders are infertile due to a failure of germ cells to progress through meiosis I and hypogonadism.
 
Phenotype Images(2)
Interactions
Ubb interacts with 64 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process adipose tissue development, energy homeostasis, ...
Component cell, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(19)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005857 (Evidence)
Ensembl Gene ModelENSMUSG00000019505 (Evidence)
Entrez Gene22187 (Evidence)
DFCITC1573622
DoTSDT.110526208, DT.91445621, DT.94281341, DT.94281452, DT.94307207, DT.94388092, DT.97395984, DT.97396120, DT.97396203
Consensus CDS ProjectCCDS24826.1
International Mouse Knockout Project StatusUbb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005857 VEGA Gene Model | MGI Sequence Detail 2043 C57BL/6J ±  kb
transcript OTTMUST00000013034 VEGA | MGI Sequence Detail 1499 Not Applicable 
polypeptide OTTMUSP00000006062 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
InterPro IPR019954 Ubiquitin conserved site
InterPro IPR019956 Ubiquitin subgroup
Protein Ontology PR:000030443 polyubiquitin-B
References
(Earliest) J:22457 Melber K, et al., Molecular cloning of sequences activated during multi-stage carcinogenesis in mouse skin. Carcinogenesis. 1986 Feb;7(2):317-22
(Latest) J:181255 Park CW, et al., Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb. Biochem Biophys Res Commun. 2012 Feb 17;418(3):541-6
All references(45)
Other
accession IDs
MGD-MRK-15326, MGD-MRK-33606, MGI:2141542

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory