About   Help   FAQ
Ubb Gene Detail
Summary
  • Symbol
    Ubb
  • Name
    ubiquitin B
  • Synonyms
    Ubb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98888
    NCBI Gene: 22187
  • Gene Overview
    MyGene.info: UBB
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:62551171-62553213 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 38.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98888
 protein coding gene Chr11:62551171-62553213 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018456
 protein coding gene Chr11:62598382-62600573 (+)
A/J MGP_AJ_G0018425
 protein coding gene Chr11:60283863-60286574 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0018396
 protein coding gene Chr11:60565739-60567553 (+)
C3H/HeJ MGP_C3HHeJ_G0018209
 protein coding gene Chr11:62123139-62126187 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018848
 protein coding gene Chr11:64573337-64574891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033068
 protein coding gene ChrX:45424272-45424810 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0018183
 protein coding gene Chr11:67365795-67367521 (+)
DBA/2J MGP_DBA2J_G0018292
 protein coding gene Chr11:59843966-59845733 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0018889
 protein coding gene Chr11:62295787-62297600 (+)
PWK/PhJ MGP_PWKPhJ_G0017539
 protein coding gene Chr11:60461887-60463782 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017329
 protein coding gene Chr11:62143473-62145057 (+)
WSB/EiJ MGP_WSBEiJ_G0017818
 protein coding gene Chr11:61910361-61912150 (+)



Homology
more
  • Human Ortholog
    UBB, ubiquitin B
  • Vertebrate Orthologs
    5
  • Human Ortholog
    UBB, ubiquitin B
    Orthology source: HGNC
  • Synonyms
    HEL-S-50
  • Links
    NCBI Gene ID: 7314
    neXtProt AC: NX_P0CG47
    UniProt: P0CG47

  • Chr Location
    17p11.2; chr17:16380793-16382745 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in progressive degeneration of hypothalamic neurons accompanied by impaired hypothalamic control of energy balance and adult-onset obesity. Both genders are infertile due to a failure of germ cells to progress through meiosis I and hypogonadism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2
  • Tissues
    1
  • cDNA Data
    18
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22187 NCBI Gene Model | MGI Sequence Detail 2043 C57BL/6J ±  kb
    transcript NM_011664 RefSeq | MGI Sequence Detail 1513 C57BL/6  
    polypeptide P0CG49 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15326, MGD-MRK-33606, MGI:2141542
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:271510 Verheijen BM, et al., Paradoxical effects of mutant ubiquitin on Abeta plaque formation in an Alzheimer mouse model. Neurobiol Aging. 2018 Dec;72:62-71
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    10/08/2019
    MGI 6.14     		The Jackson Laboratory