Ubb
Gene Detail

Symbol Name ID

Ubb ubiquitin B MGI:98888

Synonyms

Ubb2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

38.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:62551171-62553213 bp, + strand From VEGA annotation of GRCm38   2043 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74981  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle

Gene Tree: Ubb

Alleles and phenotypes

All alleles(13) : Targeted(2) Gene trapped(11)
 

Targeted disruption of this gene results in progressive degeneration of hypothalamic neurons accompanied by impaired hypothalamic control of energy balance and adult-onset obesity. Both genders are infertile due to a failure of germ cells to progress through meiosis I and hypogonadism.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	adipose tissue development, energy homeostasis, ...
Component	cytoplasm, nucleus

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 28

Assay Type	Results
RT-PCR	2

cDNA source data(19)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005857 (Evidence)
Ensembl Gene Model	ENSMUSG00000019505 (Evidence)
Entrez Gene	22187 (Evidence)
DFCI	TC1573622
DoTS	DT.110526208, DT.91445621, DT.94281341, DT.94281452, DT.94307207, DT.94388092, DT.97395984, DT.97396120, DT.97396203
Consensus CDS Project	CCDS24826.1
International Mouse Knockout Project Status	Ubb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005857	VEGA Gene Model | MGI Sequence Detail	2043	C57BL/6J
transcript	OTTMUST00000013034	VEGA | MGI Sequence Detail	1499	Not Applicable
polypeptide	OTTMUSP00000006062	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(48) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs within 2kb(26 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000626	Ubiquitin
InterPro	IPR019954	Ubiquitin conserved site
InterPro	IPR019956	Ubiquitin subgroup
InterPro	IPR019955	Ubiquitin supergroup
Protein Ontology	PR:000030443	polyubiquitin-B

References

(Earliest) J:22457 Melber K, et al., Molecular cloning of sequences activated during multi-stage carcinogenesis in mouse skin. Carcinogenesis. 1986 Feb;7(2):317-22
(Latest) J:181255 Park CW, et al., Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb. Biochem Biophys Res Commun. 2012 Feb 17;418(3):541-6
All references(45)

Other accession IDs

MGD-MRK-15326, MGD-MRK-33606, MGI:2141542