Ubb MGI Mouse Gene Detail - MGI:98888

Symbol

Ubb
Name

ubiquitin B
Synonyms

Ubb2

Feature Type

protein coding gene
IDs

MGI:98888
NCBI Gene: 22187
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:62441997-62444039 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 38.46 cM
Mapping Data

3 experiments

SNPs within 2kb

10 from dbSNP Build 142
Strain Annotations

13
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98888	protein coding gene	Chr11:62441997-62444039 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018456	protein coding gene	Chr11:62598382-62600573 (+)
A/J	MGP_AJ_G0018425	protein coding gene	Chr11:60283863-60286574 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0018396	protein coding gene	Chr11:60565739-60567553 (+)
C3H/HeJ	MGP_C3HHeJ_G0018209	protein coding gene	Chr11:62123139-62126187 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018848	protein coding gene	Chr11:64573337-64574891 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033068	protein coding gene	ChrX:45424272-45424810 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0018183	protein coding gene	Chr11:67365795-67367521 (+)
DBA/2J	MGP_DBA2J_G0018292	protein coding gene	Chr11:59843966-59845733 (+)
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0018889	protein coding gene	Chr11:62295787-62297600 (+)
PWK/PhJ	MGP_PWKPhJ_G0017539	protein coding gene	Chr11:60461887-60463782 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017329	protein coding gene	Chr11:62143473-62145057 (+)
WSB/EiJ	MGP_WSBEiJ_G0017818	protein coding gene	Chr11:61910361-61912150 (+)

Human Ortholog

UBB, ubiquitin B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBB, ubiquitin B
Synonyms

HEL-S-50
Links

HGNC:12463

NCBI Gene ID: 7314

neXtProt AC: NX_P0CG47

UniProt: P0CG47
Chr Location

17p11.2; chr17:16380793-16382745 (+) GRCh38.p7

Alliance of Genome Resources

Ubb stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: UBB
Gene Tree

Ubb

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Phenotype Summary

33 phenotypes from 1 allele in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
2 images
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Gene trapped

8
Targeted

5
Transgenic

3
Genomic Mutations

1 involving Ubb
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted disruption of this gene results in progressive degeneration of hypothalamic neurons accompanied by impaired hypothalamic control of energy balance and adult-onset obesity. Both genders are infertile due to a failure of germ cells to progress through meiosis I and hypogonadism.

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All GO Annotations

30
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

690
Tissues

15
cDNA Data

18
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ubb

ZFIN ubb

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Ubb interacts with 64 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

48
RefSeq

4
UniProt

3
CCDS

CCDS24826.1

Ensembl

ENSMUSG00000019505 (Evidence)
NCBI Gene

22187

Representative Sequences				Length	Strain/Species	Flank
	genomic	22187	NCBI Gene Model \| MGI Sequence Detail	2043	C57BL/6J	± kb

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UniProt

3 Sequences
InterPro Domains

IPR019954 Ubiquitin conserved site

IPR019956 Ubiquitin domain

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 23

cDNA 20

Primer pair 2

Other 1

Microarray probesets 5

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MGD-MRK-15326, MGD-MRK-33606, MGI:2141542

Summaries

All 79

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 36
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:311410 Park CW, et al., Disruption of the polyubiquitin gene Ubb reduces the self-renewal capacity of neural stem cells. Biochem Biophys Res Commun. 2020 Jun 25;527(2):372-378

TSS for Ubb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102022	Chr11:62441349-62441371 (+)	-637 bp
Tssr102023	Chr11:62441396-62441426 (+)	-586 bp
Tssr102024	Chr11:62441635-62441683 (+)	-338 bp
Tssr102025	Chr11:62441993-62442017 (+)	8 bp
Tssr102026	Chr11:62442060-62442072 (+)	69 bp
Tssr102027	Chr11:62442088-62442111 (+)	103 bp
Tssr102028	Chr11:62442274-62442283 (+)	282 bp
Tssr102029	Chr11:62442287-62442303 (+)	298 bp
Tssr102030	Chr11:62442319-62442329 (+)	327 bp
Tssr102031	Chr11:62442547-62442561 (+)	557 bp
Tssr102032	Chr11:62442564-62442565 (+)	568 bp
Tssr102033	Chr11:62442582-62442596 (+)	592 bp
Tssr102034	Chr11:62442600-62442647 (+)	627 bp
Tssr102035	Chr11:62442674-62442685 (+)	683 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/10/2022 MGI 6.19