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Ubb Gene Detail
Summary
  • Symbol
    Ubb
  • Name
    ubiquitin B
  • Synonyms
    Ubb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98888
    NCBI Gene: 22187
  • Gene Overview
    MyGene.info: UBB
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:62551171-62553213 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      2043 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 38.46 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    UBB, ubiquitin B
  • Vertebrate Orthologs
    5
  • Human Ortholog
    UBB, ubiquitin B
    Orthology source: HGNC
  • Synonyms
    HEL-S-50
  • Links
    NCBI Gene ID: 7314
    neXtProt AC: NX_P0CG47
    UniProt: P0CG47

  • Chr Location
    17p11.2; chr17:16380793-16382745 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human UBB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    2 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in progressive degeneration of hypothalamic neurons accompanied by impaired hypothalamic control of energy balance and adult-onset obesity. Both genders are infertile due to a failure of germ cells to progress through meiosis I and hypogonadism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2
  • Tissues
    1
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005857 VEGA Gene Model | MGI Sequence Detail 2043 C57BL/6J ±  kb
    transcript OTTMUST00000013034 VEGA | MGI Sequence Detail 1499 Not Applicable  
    polypeptide OTTMUSP00000006062 VEGA | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      26 from dbSNP Build 142
    • RFLP
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15326, MGD-MRK-33606, MGI:2141542
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:251415 Kim M, et al., Regulation of REST levels overcomes dysregulation of neural stem cell differentiation caused by disruption of polyubiquitin gene Ubb. Biochem Biophys Res Commun. 2017 Apr 22;486(1):171-177
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory