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Ubb Gene Detail
Summary
  • Symbol
    Ubb
  • Name
    ubiquitin B
  • Synonyms
    Ubb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98888
    NCBI Gene: 22187
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:62442329-62444037 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 38.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98888
 protein coding gene Chr11:62441997-62444039 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018456
 protein coding gene Chr11:62598382-62600573 (+)
A/J MGP_AJ_G0018425
 protein coding gene Chr11:60283863-60286574 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0018396
 protein coding gene Chr11:60565739-60567553 (+)
C3H/HeJ MGP_C3HHeJ_G0018209
 protein coding gene Chr11:62123139-62126187 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018848
 protein coding gene Chr11:64573337-64574891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033068
 protein coding gene ChrX:45424272-45424810 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0018183
 protein coding gene Chr11:67365795-67367521 (+)
DBA/2J MGP_DBA2J_G0018292
 protein coding gene Chr11:59843966-59845733 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0018889
 protein coding gene Chr11:62295787-62297600 (+)
PWK/PhJ MGP_PWKPhJ_G0017539
 protein coding gene Chr11:60461887-60463782 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017329
 protein coding gene Chr11:62143473-62145057 (+)
WSB/EiJ MGP_WSBEiJ_G0017818
 protein coding gene Chr11:61910361-61912150 (+)



Homology
more
  • Human Ortholog
    UBB, ubiquitin B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBB, ubiquitin B
  • Synonyms
    HEL-S-50
  • Links
    NCBI Gene ID: 7314
    UniProt: P0CG47

  • Chr Location
    17p11.2; chr17:16380779-16382745 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in progressive degeneration of hypothalamic neurons accompanied by impaired hypothalamic control of energy balance and adult-onset obesity. Both sexes are infertile due to a failure of germ cells to progress through meiosis I and hypogonadism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    16
  • cDNA Data
    18
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22187 NCBI Gene Model | MGI Sequence Detail 1709 C57BL/6J ±  kb
    transcript NM_011664 RefSeq | MGI Sequence Detail 1165 ZRU/MplStud  
    polypeptide P0CG49 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR050158 Ubiquitin and ubiquitin-like
      IPR019954 Ubiquitin conserved site
      IPR019956 Ubiquitin domain
      IPR000626 Ubiquitin-like domain
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      P0CG49 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 20
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15326, MGD-MRK-33606, MGI:2141542
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory