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U2af1 Gene Detail
Summary
  • Symbol
    U2af1
  • Name
    U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
  • Synonyms
    2010107D16Rik, 35kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:98884
    NCBI Gene: 108121
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31647081-31658892 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98884
protein coding gene Chr17:31647081-31659148 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023493
protein coding gene Chr17:31436179-31452235 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0023416
protein coding gene Chr17:30663069-30675141 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0023217
protein coding gene Chr17:31040740-31052535 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023898
protein coding gene Chr17:32520419-32535205 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021372
protein coding gene Chr17:27522199-27533459 (-)
CAST/EiJ MGP_CASTEiJ_G0022718
protein coding gene Chr17:31100688-31114264 (-)
CBA/J MGP_CBAJ_G0023192
protein coding gene Chr17:33938356-33950380 (-)
DBA/2J MGP_DBA2J_G0023322
protein coding gene Chr17:29798086-29809667 (-)
FVB/NJ MGP_FVBNJ_G0023292
protein coding gene Chr17:29597707-29610967 (-)
LP/J MGP_LPJ_G0023400
protein coding gene Chr17:31665498-31677066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023310
protein coding gene Chr17:33023369-33035671 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023940
protein coding gene Chr17:31038769-31050557 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0022286
protein coding gene Chr17:29030072-29042151 (-)
WSB/EiJ MGP_WSBEiJ_G0022780
protein coding gene Chr17:30997897-31012227 (-)



Homology
more
  • Human Ortholog
    U2AF1, U2 small nuclear RNA auxiliary factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    U2AF1, U2 small nuclear RNA auxiliary factor 1
    Orthology source: HGNC
  • Synonyms
    FP793, RN, RNU2AF1, U2AF35, U2AFBP
  • Links
    NCBI Gene ID: 7307
    neXtProt AC: NX_P0DN76, NX_Q01081
    UniProt: Q01081

  • Chr Location
    21q22.3; chr21:43092956-43108291 (-)  GRCh38.p7

Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061613 Ensembl Gene Model | MGI Sequence Detail 11812 C57BL/6J ±  kb
    transcript ENSMUST00000014684 Ensembl | MGI Sequence Detail 1046 Not Applicable  
    polypeptide ENSMUSP00000014684 Ensembl | MGI Sequence Detail 239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 19
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15321, MGI:1914284
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:300601 Tuttle KD, et al., JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. Cell Rep. 2020 Nov 17;33(7):108407

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/16/2021
    MGI 6.16
    The Jackson Laboratory