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Tyrp1
Gene Detail
 Symbol
Name
ID
Tyrp1
tyrosinase-related protein 1
MGI:98881
STS D4Mit174
Synonyms isa, Oca3, TRP1, TRP-1, Tyrp
Feature Type protein coding gene
Genetic Map
Chromosome 4
37.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(253)
Sequence Map
Chr4:80834123-80851719 bp, + strand
From VEGA annotation of GRCm38

  17597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:464  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: monophenol monooxygenase
Gene Tree: Tyrp1

Human
homologs
Human Homolog TYRP1, tyrosinase-related protein 1
NCBI Gene ID 7306
neXtProt AC  NX_P17643
Human Synonyms  b-PROTEIN, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP
Human Chr (Location)  9p23; chr9:12693385-12710285 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TYRP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Chemically and radiation induced(1) Chemically induced (ENU)(8) Chemically induced (other)(14) Radiation induced(28) Spontaneous(8) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
The major influence of mutations at this locus is to change eumelanin from a black to a brown pigment in the coat and eyes in varying degrees. Semidominant mutants result in melanocyte degeneration causing reduced pigmentation and progressive hearing loss.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(6)
Interactions
Tyrp1 interacts with 128 markers (Mir15a, Mir16-2, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process acetoacetic acid metabolic process, melanin biosynthetic process, ...
Component clathrin-coated endocytic vesicle membrane, endosome membrane, ...
Function 6-hydroxy pseudo-oxynicotine monooxygenase activity, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (213)    Tissues (112)    Images (50)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 211
RT-PCR 2
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(8) cDNA(33) Primer pair(5) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000000391 (Evidence)
Ensembl Gene ModelENSMUSG00000005994 (Evidence)
Entrez Gene22178 (Evidence)
UniGene30438
DFCITC1571920, TC1654890, TC1727951, TC1763360, TC1766739, TC1773250
DoTSDT.103564283, DT.110794123, DT.110794125, DT.110794136, DT.110794145, DT.110794151, DT.110794155, DT.111093738, DT.50315220
NIA Mouse Gene IndexU004439, U297543
EC1.14.18.-
Consensus CDS ProjectCCDS18290.1
International Mouse Knockout Project StatusTyrp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000391 VEGA Gene Model | MGI Sequence Detail 17597 C57BL/6J ±  kb
transcript OTTMUST00000000938 VEGA | MGI Sequence Detail 2623 Not Applicable 
polypeptide OTTMUSP00000000409 VEGA | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(219) RefSeq(14) UniProt(5)
Polymorphisms All PCR and RFLP(13) : PCR(3) RFLP(10) SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015559 Dihydroxyindole-2-carboxylic acid oxidase
InterPro IPR002227 Tyrosinase
InterPro IPR008922 Uncharacterised domain, di-copper centre
Protein Ontology PR:000016880 5,6-dihydroxyindole-2-carboxylic acid oxidase
References (Earliest) J:150254 Little CC, The occurrence of three recognized coat mutations in mice. Am Naturalist. 1916;1:335-349
(Latest) J:203429 Klebanoff CA, et al., Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med. 2013 Sep 23;210(10):1961-76
All references(326)
Other
accession IDs
MGD-MRK-1491, MGD-MRK-15316, MGD-MRK-23790, MGI:1336195

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory