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Tyrp1
Gene Detail
Symbol

Name
ID
Tyrp1
tyrosinase-related protein 1
MGI:98881
STS
Synonyms
isa, Oca3, TRP1, TRP-1, Tyrp
Feature Type
protein coding gene
Genetic Map
Chromosome 4
37.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(253)
Sequence Map
Chr4:80834123-80851719 bp, + strand
From VEGA annotation of GRCm38

  17597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:464  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TYRP1
Protein SuperFamily: monophenol monooxygenase
Gene Tree: Tyrp1

Human
homologs
TYRP1, tyrosinase-related protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7306
neXtProt AC: NX_P17643

Human Synonyms: b-PROTEIN, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP

Human Chr (Location): 9p23; chr9:12693386-12710266 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TYRP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(61) : Chemically and radiation induced(1) Chemically induced (ENU)(9) Chemically induced (other)(14) Radiation induced(28) Spontaneous(8) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
The major influence of mutations at this locus is to change eumelanin from a black to a brown pigment in the coat and eyes in varying degrees. Semidominant mutants result in melanocyte degeneration causing reduced pigmentation and progressive hearing loss.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(7)
Interactions
Tyrp1 interacts with 128 markers (Mir15a, Mir16-2, Mir25, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (213)    Tissues (112)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 211
RT-PCR 2
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tyrp1 ; ZFIN tyrp1a    NEW 
Molecular
reagents
All nucleic(47) Genomic(8) cDNA(33) Primer pair(5) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000000391 (Evidence)
Ensembl Gene Model ENSMUSG00000005994 (Evidence)
Entrez Gene 22178 (Evidence)
UniGene 30438
DFCI TC1571920, TC1654890, TC1727951, TC1763360, TC1766739, TC1773250
DoTS DT.103564283, DT.110794123, DT.110794125, DT.110794136, DT.110794145, DT.110794151, DT.110794155, DT.111093738, DT.50315220
NIA Mouse Gene Index U004439, U297543
EC 1.14.18.-
Consensus CDS Project CCDS18290.1
International Mouse Phenotyping Consortium Status Tyrp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000391 VEGA Gene Model | MGI Sequence Detail 17597 C57BL/6J ±  kb
transcript OTTMUST00000000938 VEGA | MGI Sequence Detail 2623 Not Applicable 
polypeptide OTTMUSP00000000409 VEGA | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(219) RefSeq(14) UniProt(5)
Polymorphisms
All PCR and RFLP(13) : PCR(3) RFLP(10) SNPs within 2kb(157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015559 Dihydroxyindole-2-carboxylic acid oxidase
InterPro IPR002227 Tyrosinase copper-binding domain
InterPro IPR008922 Uncharacterised domain, di-copper centre
Protein Ontology PR:000016880 5,6-dihydroxyindole-2-carboxylic acid oxidase
References
(Earliest) J:150254 Little CC, The occurrence of three recognized coat mutations in mice. Am Naturalist. 1916;1:335-349
(Latest) J:203429 Klebanoff CA, et al., Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med. 2013 Sep 23;210(10):1961-76
All references(321)
Other
accession IDs
MGD-MRK-1491, MGD-MRK-15316, MGD-MRK-23790, MGI:1336195

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory