Tuba1a
Gene Detail

Symbol Name ID

Tuba1a tubulin, alpha 1A MGI:98869

Synonyms

Talpha1 alpha-tubulin, Tuba1, Tuba-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

55.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:98949841-98953551 bp, - strand From VEGA annotation of GRCm38   3711 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tuba1a

Human homologs

Human Homolog		TUBA1A, tubulin, alpha 1a
NCBI Gene ID		7846
neXtProt AC		NX_Q71U36
Human Synonyms		B-ALPHA-1, LIS3, TUBA3
Human Chr (Location)		12q13.12; chr12:49578578-49583107 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TUBA1A

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(4) Chemically induced(2)
 

Heterozygous mutation of this gene results in hyperactivity, reduced anxiety, impaired spatial working memory, and abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration.

 
Human Diseases Modeled Using Mouse Tuba1a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	GTP catabolic process, microtubule-based process, ...
Component	cytoplasm, cytoplasmic microtubule, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (122)    Tissues (41)    Images (4)
Theiler Stages: 12, 16, 17, 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	19
Northern blot	70
RT-PCR	33

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(20) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017053 (Evidence)
Ensembl Gene Model	ENSMUSG00000072235 (Evidence)
Entrez Gene	22142 (Evidence)
DoTS	DT.101182137, DT.91324374, DT.91584272, DT.97377593, DT.99872770, DT.99872786
Consensus CDS Project	CCDS37196.1
International Mouse Knockout Project Status	Tuba1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017053	VEGA Gene Model | MGI Sequence Detail	3711	C57BL/6J
transcript	OTTMUST00000041305	VEGA | MGI Sequence Detail	1647	Not Applicable
polypeptide	OTTMUSP00000018539	VEGA | MGI Sequence Detail	451	Not Applicable

All sequences(37) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002452	Alpha tubulin
InterPro	IPR000217	Tubulin
InterPro	IPR017975	Tubulin, conserved site
InterPro	IPR023123	Tubulin, C-terminal
InterPro	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
InterPro	IPR008280	Tubulin/FtsZ, C-terminal
InterPro	IPR003008	Tubulin/FtsZ, GTPase domain
Protein Ontology	PR:000016807	tubulin alpha-1A chain

References

(Earliest) J:41039 Howe CC, et al., Post-transcriptional regulation of the abundance of mRNAs encoding alpha-tubulin and a 94,000-dalton protein in teratocarcinoma-derived stem cells versus differentiated cells. Mol Cell Biol. 1984 Nov;4(11):2428-36
(Latest) J:185786 Chawengsaksophak K, et al., Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biol Reprod. 2012 Jan;86(1):1-12
All references(70)

Other accession IDs

MGD-MRK-15300, MGD-MRK-15301