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Tuba1a
Gene Detail
Symbol

Name
ID
Tuba1a
tubulin, alpha 1A
MGI:98869
Synonyms
Talpha1 alpha-tubulin, Tuba1, Tuba-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
55.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:98949841-98953551 bp, - strand
From VEGA annotation of GRCm38

  3711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TUBA1A
Gene Tree: Tuba1a

Human
homologs
TUBA1A, tubulin, alpha 1a
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7846
neXtProt AC: NX_Q71U36

Human Synonyms: B-ALPHA-1, LIS3, TUBA3

Human Chr (Location): 12q13.12; chr12:49184795-49189324 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TUBA1A

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Gene trapped(4) Radiation induced(1) Targeted(3)
Genomic Mutations involving Tuba1a (1)
 
Heterozygous mutation of this gene results in hyperactivity, reduced anxiety, impaired spatial working memory, and abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration.
 
Human Diseases Modeled in Mice Using Tuba1a (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Tuba1a interacts with 69 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process microtubule-based process, protein polymerization
Component cytoplasm, cytoplasmic microtubule, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (122)    Tissues (49)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
Northern blot 70
RT-PCR 33
cDNA source data(908)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tuba1a, tuba4 ; ZFIN tuba1a    NEW 
Molecular
reagents
All nucleic(915) cDNA(911) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017053 (Evidence)
Ensembl Gene Model ENSMUSG00000072235 (Evidence)
Entrez Gene 22142 (Evidence)
UniGene 405359
DoTS DT.101182137, DT.91324374, DT.91584272, DT.97377593, DT.99872770, DT.99872786
Consensus CDS Project CCDS37196.1
International Mouse Phenotyping Consortium Status Tuba1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017053 VEGA Gene Model | MGI Sequence Detail 3711 C57BL/6J ±  kb
transcript OTTMUST00000041305 VEGA | MGI Sequence Detail 1647 Not Applicable 
polypeptide OTTMUSP00000018539 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)    SNPs within 2kb including multiple locations(50)
Protein-related
information
ResourceIDDescription
InterPro IPR002452 Alpha tubulin
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016807 tubulin alpha-1A chain
References
(Earliest) J:41039 Howe CC, et al., Post-transcriptional regulation of the abundance of mRNAs encoding alpha-tubulin and a 94,000-dalton protein in teratocarcinoma-derived stem cells versus differentiated cells. Mol Cell Biol. 1984 Nov;4(11):2428-36
(Latest) J:203056 Hines EA, et al., Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19444-9
All references(76)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15300, MGD-MRK-15301

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory