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Psmd3 Gene Detail
Summary
  • Symbol
    Psmd3
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
  • Synonyms
    AntP91a, Psd3, Tstap91a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98858
    NCBI Gene: 22123
  • Gene Overview
    MyGene.info: PSMD3
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98682554-98695978 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.39 cM
  • Mapping Data
    9 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98858
protein coding gene Chr11:98682554-98695979 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019068
protein coding gene Chr11:101274348-101288536 (+)
A/J MGP_AJ_G0019036
protein coding gene Chr11:97038411-97051576 (+)
AKR/J MGP_AKRJ_G0019006
protein coding gene Chr11:100046786-100061608 (+)
BALB/cJ MGP_BALBcJ_G0019010
protein coding gene Chr11:97533566-97546521 (+)
C3H/HeJ MGP_C3HHeJ_G0018823
protein coding gene Chr11:100188531-100201497 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019461
protein coding gene Chr11:104360253-104373418 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017093
protein coding gene Chr11:94595278-94609055 (+)
CAST/EiJ MGP_CASTEiJ_G0018377
protein coding gene Chr11:101172283-101185161 (+)
CBA/J MGP_CBAJ_G0018794
protein coding gene Chr11:108726716-108740182 (+)
DBA/2J MGP_DBA2J_G0018902
protein coding gene Chr11:96597744-96610881 (+)
FVB/NJ MGP_FVBNJ_G0018891
protein coding gene Chr11:96105077-96120548 (+)
LP/J MGP_LPJ_G0018972
protein coding gene Chr11:101735388-101748330 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018918
protein coding gene Chr11:108440452-108459193 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019501
protein coding gene Chr11:100388892-100403350 (+)
PWK/PhJ MGP_PWKPhJ_G0018148
protein coding gene Chr11:97629126-97642993 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017937
protein coding gene Chr11:100134296-100147719 (+)
WSB/EiJ MGP_WSBEiJ_G0018426
protein coding gene Chr11:100340892-100355285 (+)



Homology
more
  • Human Ortholog
    PSMD3, proteasome 26S subunit, non-ATPase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PSMD3, proteasome 26S subunit, non-ATPase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P58, RPN3, S3, TSTA2
  • Links
    NCBI Gene ID: 5709
    neXtProt AC: NX_O43242
    UniProt: O43242

  • Chr Location
    17q21.1; chr17:39980768-39997960 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22123 NCBI Gene Model | MGI Sequence Detail 13425 C57BL/6J ±  kb
transcript NM_009439 RefSeq | MGI Sequence Detail 2167 FVB/N  
polypeptide P14685 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013387 26S proteasome non-ATPase regulatory subunit 3
  • InterPro Domains
    IPR035267 26S proteasome non-ATPase regulatory subunit 3
    IPR013586 26S proteasome regulatory subunit, C-terminal
    IPR000717 Proteasome component (PCI) domain
    IPR036390 Winged helix DNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 276
    Genomic 4
    cDNA 269
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15286, MGD-MRK-34053, MGI:2144092
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:52726 Uyttenhove C, et al., Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice. J Exp Med. 1980 Nov 1;152(5):1175-83
  • Latest
    J:236006 Hjerpe R, et al., UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome. Cell. 2016 Aug 11;166(4):935-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory