Tsta3 Gene Detail

Summary

• Symbol
  Tsta3
• Name
  tissue specific transplantation antigen P35B
• Synonyms
  FX, GDP-fucose synthase, Tstap35b

• Feature Type
  protein coding gene
• IDs
  MGI:98857
  NCBI Gene: 22122
• Gene Overview
  MyGene.info: TSTA3

Location & Maps

• Sequence Map
  Chr15:75924684-75929730 bp, - strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    5047 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 35.10 cM
• Mapping Data
  4 experiments

Homology

• Human Ortholog
  TSTA3, tissue specific transplantation antigen P35B

• Vertebrate Orthologs
  10

• Human Ortholog
  TSTA3, tissue specific transplantation antigen P35B
  Orthology source: HomoloGene, HGNC
• Synonyms
  FX, P35B, SDR4E1
• Links
  HGNC:12390

  NCBI Gene ID: 7264

  neXtProt AC: NX_Q13630

  
  
• Chr Location
  8q24.3; chr8:143612618-143618043 (-)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 2484
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish
  
• HCOP
  human homology predictions: TSTA3
• Gene Tree
  Tsta3
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  19 phenotypes from 1 allele in 1 genetic background
  1 images
  36 phenotype references
  

• All Mutations and Alleles
  14
• Chemically induced (other)
  3
• Gene trapped
  5
• Radiation induced
  2
• Targeted
  4
• Genomic Mutations
  5 involving Tsta3
• Incidental Mutations
  Mutagenetix , APF

Homozygotes for a targeted null mutation frequently die in utero, while survivors are smaller than normal, show colon abnormalities, have reduced fertility, and frequently die before weaning. Heterozygotes also show some embryonic loss.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  14
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  120

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase tsta3

Interactions

• Tsta3 interacts with 38 markers (Mir24-1, Mir24-2, Mir29b-2, ...) View All

Sequences &
Gene Models

• All Sequences
  40
• RefSeq
  16
• UniProt
  2
• CCDS
  CCDS27555.1
• UniGene
  22596

• Ensembl
  ENSMUSG00000022570 (Evidence)
• NCBI Gene
  22122

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000022570	Ensembl Gene Model | MGI Sequence Detail	5047	C57BL/6J
transcript	ENSMUST00000023231	Ensembl | MGI Sequence Detail	1311	Not Applicable
polypeptide	ENSMUSP00000023231	Ensembl | MGI Sequence Detail	321	Not Applicable

Polymorphisms

• SNPs within 2kb
  52 from dbSNP Build 142

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000016776 GDP-L-fucose synthetase
• EC
  1.1.1.271
• InterPro Domains
  IPR028614 GDP-L-fucose synthase/GDP-L-colitose synthase
  IPR001509 NAD-dependent epimerase/dehydratase
  IPR016040 NAD(P)-binding domain

Molecular
Reagents

• All nucleic 121

  Genomic 1

  cDNA 120

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-15285, MGI:2145965

References

• Summaries
  All 42

  Diseases 1

  Gene Ontology 4

  Phenotypes 36
• Earliest
  J:52726 Uyttenhove C, et al., Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice. J Exp Med. 1980 Nov 1;152(5):1175-83
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42