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Tsta3
Gene Detail
Symbol

Name
ID
Tsta3
tissue specific transplantation antigen P35B
MGI:98857
Synonyms
FX, GDP-fucose synthase, Tstap35b
Feature Type
protein coding gene
Genetic Map
Chromosome 15
35.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:75924684-75929730 bp, - strand
From Ensembl annotation of GRCm38

  5047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2484  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: TSTA3
Gene Tree: Tsta3

Human
homologs
TSTA3, tissue specific transplantation antigen P35B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7264
neXtProt AC: NX_Q13630

Human Synonyms: FX, P35B, SDR4E1

Human Chr (Location): 8q24.3; chr8:143612618-143618043 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Radiation induced(1) Targeted(4)
Genomic Mutations involving Tsta3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation frequently die in utero, while survivors are smaller than normal, show colon abnormalities, have reduced fertility, and frequently die before weaning. Heterozygotes also show some embryonic loss.
 
Phenotype Images(3)
Interactions
Tsta3 interacts with 38 markers (Mir24-1, Mir24-2, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cytolysis, 'de novo' GDP-L-fucose biosynthetic process, ...
Component extracellular exosome
Function catalytic activity, coenzyme binding, ...
External Resources: FuncBase
Expression
cDNA source data(120)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tsta3    NEW 
Molecular
reagents
All nucleic(121) Genomic(1) cDNA(120)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022570 (Evidence)
Entrez Gene 22122 (Evidence)
UniGene 22596
DFCI TC1575150
DoTS DT.492936
NIA Mouse Gene Index U036318
EC 1.1.1.271
Consensus CDS Project CCDS27555.1
International Mouse Phenotyping Consortium Status Tsta3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022570 Ensembl Gene Model | MGI Sequence Detail 5047 C57BL/6J ±  kb
transcript ENSMUST00000023231 Ensembl | MGI Sequence Detail 1311 Not Applicable 
polypeptide ENSMUSP00000023231 Ensembl | MGI Sequence Detail 321 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(16) UniProt(2)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028614 GDP-L-fucose synthase
InterPro IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000016776 GDP-L-fucose synthetase
References
(Earliest) J:52726 Uyttenhove C, et al., Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice. J Exp Med. 1980 Nov 1;152(5):1175-83
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)
Other
accession IDs
MGD-MRK-15285, MGI:2145965

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory