Gfus MGI Mouse Gene Detail - MGI:98857

Symbol

Gfus
Name

GDP-L-fucose synthase
Synonyms

FX, Tsta3, Tstap35b

Feature Type

protein coding gene
IDs

MGI:98857
NCBI Gene: 22122
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:75796532-75801613 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.10 cM
Mapping Data

4 experiments

SNPs within 2kb

359 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98857	protein coding gene	Chr15:75796525-75801681 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021966	protein coding gene	Chr15:75974152-75979198 (-)
A/J	MGP_AJ_G0021924	protein coding gene	Chr15:73206617-73212323 (-)
AKR/J	MGP_AKRJ_G0021907	protein coding gene	Chr15:75185510-75190592 (-)
BALB/cJ	MGP_BALBcJ_G0021933	protein coding gene	Chr15:73227967-73233041 (-)
C3H/HeJ	MGP_C3HHeJ_G0021705	protein coding gene	Chr15:75246537-75251629 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022373	protein coding gene	Chr15:78810747-78816794 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019904	protein coding gene	Chr15:69879672-69884727 (-)
CAST/EiJ	MGP_CASTEiJ_G0021224	protein coding gene	Chr15:76029503-76034536 (-)
CBA/J	MGP_CBAJ_G0021672	protein coding gene	Chr15:81325295-81330440 (-)
DBA/2J	MGP_DBA2J_G0021797	protein coding gene	Chr15:72737750-72742796 (-)
FVB/NJ	MGP_FVBNJ_G0021778	protein coding gene	Chr15:71788324-71794604 (-)
LP/J	MGP_LPJ_G0021868	protein coding gene	Chr15:76055599-76061295 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021802	protein coding gene	Chr15:86628779-86633950 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022393	protein coding gene	Chr15:75430031-75435077 (-)
PWK/PhJ	MGP_PWKPhJ_G0020965	protein coding gene	Chr15:72874895-72879935 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020804	protein coding gene	Chr15:75159899-75165005 (-)
WSB/EiJ	MGP_WSBEiJ_G0021276	protein coding gene	Chr15:75517321-75522367 (-)

Human Ortholog

GFUS, GDP-L-fucose synthase

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GFUS, GDP-L-fucose synthase
Synonyms

FX, P35B, SDR4E1, TSTA3
Links

HGNC:12390

NCBI Gene ID: 7264

UniProt: Q13630
Chr Location

8q24.3; chr8:143612618-143618048 (-) GRCh38

MGI Vertebrate Homology

Gfus stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: GFUS
Gene Tree

Gfus

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References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
1 images
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

2
Targeted

4
Genomic Mutations

5 involving Gfus
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation frequently die in utero, while survivors are smaller than normal, show colon abnormalities, have reduced fertility, and frequently die before weaning. Heterozygotes also show some embryonic loss.

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All GO Annotations

35
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

121

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gfus

ZFIN gfus.3

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All Sequences

83
RefSeq

16
UniProt

7
CCDS

CCDS27555.1

Ensembl

ENSMUSG00000022570 (Evidence)
NCBI Gene

22122

			Length	Strain/Species	Flank
genomic	22122	NCBI Gene Model \| MGI Sequence Detail	5082	C57BL/6J	± kb
transcript	NM_001411816	RefSeq \| MGI Sequence Detail	1436	ZRU/MplStud
polypeptide	P23591	UniProt \| EBI \| MGI Sequence Detail	321	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016776 GDP-L-fucose synthetase

(term hierarchy)
EC

1.1.1.271
InterPro Domains

IPR028614 GDP-L-fucose synthase/GDP-L-colitose synthase

IPR001509 NAD-dependent epimerase/dehydratase

IPR036291 NAD(P)-binding domain superfamily

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All nucleic 122

Genomic 1

cDNA 121

Microarray probesets 3

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MGD-MRK-15285, MGI:2145965, MGI:6415194

Summaries

All 78

Diseases 1

Gene Ontology 13

Phenotypes 41
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:327024 Wang L, et al., Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis. Cancer Immunol Res. 2021 Mar;9(3):348-361

TSS for Gfus:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134890	Chr15:75801630-75801641 (-)	-23 bp
Tssr134889	Chr15:75801582-75801621 (-)	11 bp
Tssr134888	Chr15:75801547-75801568 (-)	55 bp
Tssr134887	Chr15:75800495-75800537 (-)	1,097 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24