Tsta3
Gene Detail

Symbol

Name
ID

Tsta3
tissue specific transplantation antigen P35B
MGI:98857

Synonyms

FX, GDP-fucose synthase, Tstap35b

Feature Type

protein coding gene

Genetic Map

Chromosome 15
35.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:75924684-75929730 bp, - strand From Ensembl annotation of GRCm38   5047 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2484  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Tsta3

Human
homologs

Human Homolog		TSTA3, tissue specific transplantation antigen P35B
NCBI Gene ID		7264
neXtProt AC		NX_Q13630
Human Synonyms		FX, P35B, SDR4E1
Human Chr (Location)		8q24.3; chr8:143612618-143618155 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Gene trapped(5) Radiation induced(1) Targeted(4)
Genomic Mutations involving Tsta3 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation frequently die in utero, while survivors are smaller than normal, show colon abnormalities, have reduced fertility, and frequently die before weaning. Heterozygotes also show some embryonic loss.

 
Phenotype Images(3)

Interactions

Tsta3 interacts with 38 markers (Mir24-1, Mir24-2, Mir29b-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (12 annotations)

Process	cytolysis, 'de novo' GDP-L-fucose biosynthetic process, ...
Component	extracellular vesicular exosome
Function	catalytic activity, coenzyme binding, ...

External Resources: FuncBase

Expression

cDNA source data(120)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(121) Genomic(1) cDNA(120)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000022570 (Evidence)
Entrez Gene	22122 (Evidence)
UniGene	22596
DFCI	TC1575150
DoTS	DT.492936
NIA Mouse Gene Index	U036318
EC	1.1.1.271
Consensus CDS Project	CCDS27555.1
International Mouse Knockout Project Status	Tsta3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022570	Ensembl Gene Model | MGI Sequence Detail	5047	C57BL/6J
transcript	ENSMUST00000023231	Ensembl | MGI Sequence Detail	1311	Not Applicable
polypeptide	ENSMUSP00000023231	Ensembl | MGI Sequence Detail	321	Not Applicable

All sequences(46) RefSeq(18) UniProt(3)

Polymorphisms

SNPs within 2kb(52 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001509	NAD-dependent epimerase/dehydratase
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000016776	GDP-L-fucose synthetase

References

(Earliest) J:52726 Uyttenhove C, et al., Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice. J Exp Med. 1980 Nov 1;152(5):1175-83
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)

Other
accession IDs

MGD-MRK-15285, MGI:2145965