Tshb
Gene Detail

Symbol Name ID

Tshb thyroid stimulating hormone, beta subunit MGI:98848

STS

D3Nds8

Synonyms

thyrotropin

Feature Type

protein coding gene

Genetic Map

Chromosome 3

45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr3:102777398-102782714 bp, - strand From NCBI annotation of GRCm38   5317 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Tshb

Human homologs

Human Homolog		TSHB, thyroid stimulating hormone, beta
NCBI Gene ID		7252
neXtProt AC		NX_P01222
Human Synonyms		TSH-B, TSH-BETA
Human Chr (Location)		1p13; chr1:115572415-115576941 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TSHB

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Component	extracellular region
Function	hormone activity

External Resources: FuncBase

Expression

Literature Summary: (75 records)
Data Summary: Results (41)    Tissues (29)    Images (10)
Theiler Stages: 9, 11, 13, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	21
RT-PCR	13

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(8) cDNA(9) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000027857 (Evidence)
Entrez Gene	22094 (Evidence)
UniGene	110730
DFCI	TC1590510
DoTS	DT.40139877, DT.91318715, DT.94286236, DT.94286237
NIA Mouse Gene Index	U024447
Consensus CDS Project	CCDS17689.1
International Mouse Knockout Project Status	Tshb

Sequences

Length	Strain/Species
genomic	22094	NCBI Gene Model | MGI Sequence Detail	5317	C57BL/6J
transcript	NM_009432	RefSeq | MGI Sequence Detail	645	C57BL/6
polypeptide	P12656	UniProt | EBI | MGI Sequence Detail	138	Not Applicable

All sequences(39) RefSeq(6) UniProt(3)

Polymorphisms

All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006208	Cystine knot
InterPro	IPR001545	Gonadotropin, beta subunit
InterPro	IPR018245	Gonadotropin, beta subunit, conserved site
Protein Ontology	PR:000016724	thyrotropin subunit beta

Graphical View of Protein Domain Structure

References

(Earliest) J:46050 Ainger LE, et al., Familial athyreotic cretinism: report of 3 cases. J Clin Endocrinol. 1955;15:469-475
(Latest) J:191667 Jayakody SA, et al., SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
All references(136)

Other accession IDs

MGD-MRK-15274