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Tshb
Gene Detail
Symbol

Name
ID
Tshb
thyroid stimulating hormone, beta subunit
MGI:98848
STS
Synonyms
thyrotropin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr3:102777398-102782714 bp, - strand
From Ensembl annotation of GRCm38

  5317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Tshb

Human
homologs
Human Homolog TSHB, thyroid stimulating hormone, beta
NCBI Gene ID 7252
neXtProt AC  NX_P01222
Human Synonyms  TSH-B, TSH-BETA
Human Chr (Location)  1p13; chr1:115029824-115034309 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TSHB
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Interactions
Tshb interacts with 15 markers (Mir30a, Mir30b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component cytoplasm, extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (43)    Tissues (30)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 21
RT-PCR 13
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(8) cDNA(10) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027857 (Evidence)
Entrez Gene22094 (Evidence)
UniGene110730
DFCITC1590510, TC1606691
DoTSDT.40139877, DT.87038842, DT.91318715, DT.94286236, DT.94286237
Consensus CDS ProjectCCDS17689.1
International Mouse Knockout Project StatusTshb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027857 Ensembl Gene Model | MGI Sequence Detail 5317 C57BL/6J ±  kb
transcript ENSMUST00000029450 Ensembl | MGI Sequence Detail 645 Not Applicable 
polypeptide ENSMUSP00000029450 Ensembl | MGI Sequence Detail 138 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(20) UniProt(5)
Polymorphisms
All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR001545 Gonadotropin, beta subunit
InterPro IPR018245 Gonadotropin, beta subunit, conserved site
Protein Ontology PR:000016724 thyrotropin subunit beta
References
(Earliest) J:46050 Ainger LE, et al., Familial athyreotic cretinism: report of 3 cases. J Clin Endocrinol. 1955;15:469-475
(Latest) J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
All references(141)
Other
accession IDs
MGD-MRK-15274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory