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Tshb
Gene Detail
Symbol

Name
ID
Tshb
thyroid stimulating hormone, beta subunit
MGI:98848
STS
Synonyms
thyrotropin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr3:102777398-102782714 bp, - strand
From Ensembl annotation of GRCm38

  5317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:463  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TSHB
Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Tshb

Human
homologs
TSHB, thyroid stimulating hormone, beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7252
neXtProt AC: NX_P01222

Human Synonyms: TSH-B, TSH-BETA

Human Chr (Location): 1p13; chr1:115029824-115034309 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TSHB

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for a knock-out allele exhibit infertility and growth retardation.
 
Interactions
Tshb interacts with 15 markers (Mir30a, Mir30b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component cytoplasm, extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (44)    Tissues (31)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 21
RT-PCR 13
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TSHB ; Xenbase tshb ; ZFIN tshba    NEW 
Molecular
reagents
All nucleic(24) Genomic(8) cDNA(10) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000027857 (Evidence)
Entrez Gene 22094 (Evidence)
UniGene 110730
DFCI TC1590510, TC1606691
DoTS DT.40139877, DT.87038842, DT.91318715, DT.94286236, DT.94286237
Consensus CDS Project CCDS17689.1
International Mouse Phenotyping Consortium Status Tshb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027857 Ensembl Gene Model | MGI Sequence Detail 5317 C57BL/6J ±  kb
transcript ENSMUST00000029450 Ensembl | MGI Sequence Detail 645 Not Applicable 
polypeptide ENSMUSP00000029450 Ensembl | MGI Sequence Detail 138 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(20) UniProt(3)
Polymorphisms
All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR001545 Gonadotropin, beta subunit
InterPro IPR018245 Gonadotropin, beta subunit, conserved site
Protein Ontology PR:000016724 thyrotropin subunit beta
References
(Earliest) J:46050 Ainger LE, et al., Familial athyreotic cretinism: report of 3 cases. J Clin Endocrinol. 1955;15:469-475
(Latest) J:218295 Mortensen AH, et al., Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
All references(143)
Other
accession IDs
MGD-MRK-15274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory