About   Help   FAQ
Kdm3a
Gene Detail
 Symbol
Name
ID
Kdm3a
lysine (K)-specific demethylase 3A
MGI:98847
Synonyms 1700105C21Rik, C230043E16Rik, Jmjd1, Jmjd1a, mKIAA0742, Tsga
Feature Type protein coding gene
Genetic Map
Chromosome 6
32.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:71588974-71632905 bp, - strand
From Ensembl annotation of GRCm38

  43932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Kdm3a

Human
homologs
Human Homolog KDM3A, lysine (K)-specific demethylase 3A
NCBI Gene ID 55818
neXtProt AC  NX_Q9Y4C1
Human Synonyms  JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA
Human Chr (Location)  2p11.2; chr2:86441148-86492716 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(83) : Gene trapped(77) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a hypomorphic allele display infertility, oligoasthenoteratozoospermia, small testis, and impaired spermiogenesis. Mice homozygous for a null allele exhibit abnormal spermatogenesis and obesity associated with hyperlipidemia.
 
Human Diseases Modeled Using Mouse Kdm3a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Kdm3a interacts with 246 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process androgen receptor signaling pathway, cell differentiation, ...
Component cytoplasm, membrane, ...
Function 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, androgen receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 25
Assay TypeResults
RT-PCR 2
cDNA source data(275)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(277) cDNA(276) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000053470 (Evidence)
Entrez Gene104263 (Evidence)
UniGene260479
DFCITC1572642, TC1590666
DoTSDT.101156341, DT.101280122, DT.110493111, DT.493142, DT.97350439
NIA Mouse Gene IndexU027459
EC1.14.11.-
Consensus CDS ProjectCCDS20233.1
International Mouse Knockout Project StatusKdm3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053470 Ensembl Gene Model | MGI Sequence Detail 43932 C57BL/6J ±  kb
transcript ENSMUST00000065509 Ensembl | MGI Sequence Detail 4814 Not Applicable 
polypeptide ENSMUSP00000065716 Ensembl | MGI Sequence Detail 1323 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(14) UniProt(5)
Polymorphisms SNPs within 2kb(156 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003347 JmjC domain
Protein Ontology PR:000009211 lysine-specific demethylase 3A
References (Earliest) J:11619 Hoog C, et al., Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein. Mol Reprod Dev. 1991 Nov;30(3):173-81
(Latest) J:210696 Gillett A, et al., A silent exonic SNP in kdm3a affects nucleic acids structure but does not regulate experimental autoimmune encephalomyelitis. PLoS One. 2013;8(12):e81912
All references(50)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15272, MGI:1920820, MGI:2444882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory