Kdm3a
Gene Detail

Symbol Name ID

Kdm3a lysine (K)-specific demethylase 3A MGI:98847

Synonyms

1700105C21Rik, C230043E16Rik, Jmjd1, Jmjd1a, mKIAA0742, Tsga

Feature Type

protein coding gene

Genetic Map

Chromosome 6

32.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:71588974-71632905 bp, - strand From Ensembl annotation of GRCm38   43932 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10196  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Kdm3a

Human homologs

Human Homolog		KDM3A, lysine (K)-specific demethylase 3A
NCBI Gene ID		55818
neXtProt AC		NX_Q9Y4C1
Human Synonyms		JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA
Human Chr (Location)		2p11.2; chr2:86668271-86719839 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(83) : Targeted(6) Gene trapped(77)
 

Male mice homozygous for a hypomorphic allele display infertility, oligoasthenoteratozoospermia, small testis, and impaired spermiogenesis. Mice homozygous for a null allele exhibit abnormal spermatogenesis and obesity associated with hyperlipidemia.

 
Human Diseases Modeled Using Mouse Kdm3a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	androgen receptor signaling pathway, cell differentiation, ...
Component	cytoplasm, nucleus
Function	androgen receptor binding, core promoter binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 25

Assay Type	Results
RT-PCR	2

cDNA source data(273)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(275) cDNA(274) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000053470 (Evidence)
Entrez Gene	104263 (Evidence)
UniGene	260479
DFCI	TC1572642, TC1590666
DoTS	DT.101156341, DT.101280122, DT.110493111, DT.493142, DT.97350439
NIA Mouse Gene Index	U027459
EC	1.14.11.-
Consensus CDS Project	CCDS20233.1
International Mouse Knockout Project Status	Kdm3a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000053470	Ensembl Gene Model | MGI Sequence Detail	43932	C57BL/6J
transcript	ENSMUST00000065509	Ensembl | MGI Sequence Detail	4814	Not Applicable
polypeptide	ENSMUSP00000065716	Ensembl | MGI Sequence Detail	1323	Not Applicable

All sequences(41) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(148 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003347	JmjC domain
Protein Ontology	PR:000009211	JmjC domain-containing histone demethylation protein 2A

References

(Earliest) J:11619 Hoog C, et al., Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein. Mol Reprod Dev. 1991 Nov;30(3):173-81
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)

Other accession IDs

MGD-MRK-15272, MGI:1920820, MGI:2444882