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Kdm3a Gene Detail
Summary
  • Symbol
    Kdm3a
  • Name
    lysine (K)-specific demethylase 3A
  • Synonyms
    1700105C21Rik, C230043E16Rik, Jmjd1, Jmjd1a, mKIAA0742, Tsga
  • Feature Type
    protein coding gene
  • IDs
    MGI:98847
    NCBI Gene: 104263
Location & Maps
more
  • Sequence Map
    Chr6:71588972-71632990 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44019 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.18 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KDM3A, lysine demethylase 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KDM3A, lysine demethylase 3A
    Orthology source: HomoloGene
  • Synonyms
    JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA
  • Links
    NCBI Gene ID: 55818
    neXtProt AC: NX_Q9Y4C1

  • Chr Location
    2p11.2; chr2:86440647-86492716 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Kdm3a mouse models

Human Disease Mouse Models
       Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 4 alleles in 5 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    84
  • Gene trapped
    77
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Kdm3a
  • Incidental Mutations
Male mice homozygous for a hypomorphic allele display infertility, oligoasthenoteratozoospermia, small testis, and impaired spermiogenesis. Mice homozygous for a null allele exhibit abnormal spermatogenesis and obesity associated with hyperlipidemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057914 VEGA Gene Model | MGI Sequence Detail 44019 C57BL/6J ±  kb
transcript OTTMUST00000142199 VEGA | MGI Sequence Detail 4816 Not Applicable  
polypeptide OTTMUSP00000074224 VEGA | MGI Sequence Detail 1323 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 277
    cDNA 276
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15272, MGI:1920820, MGI:2444882
References
more
  • Summaries
    All 50
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:11619 Hoog C, et al., Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein. Mol Reprod Dev. 1991 Nov;30(3):173-81
  • Latest
    J:224345 Ueda J, et al., The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth. Mol Cell Biol. 2014 Oct 1;34(19):3702-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory