About   Help   FAQ
Kdm3a Gene Detail
Summary
  • Symbol
    Kdm3a
  • Name
    lysine (K)-specific demethylase 3A
  • Synonyms
    1700105C21Rik, C230043E16Rik, Jmjd1, Jmjd1a, mKIAA0742, Tsga
  • Feature Type
    protein coding gene
  • IDs
    MGI:98847
    NCBI Gene: 104263
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:71588972-71632990 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44019 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.18 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KDM3A, lysine demethylase 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KDM3A, lysine demethylase 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA
  • Links
    NCBI Gene ID: 55818
    neXtProt AC: NX_Q9Y4C1
    UniProt: Q9Y4C1

  • Chr Location
    2p11.2; chr2:86440647-86492716 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Kdm3a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 4 alleles in 5 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a hypomorphic allele display infertility, oligoasthenoteratozoospermia, small testis, and impaired spermiogenesis. Mice homozygous for a null allele exhibit abnormal spermatogenesis and obesity associated with hyperlipidemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057914 VEGA Gene Model | MGI Sequence Detail 44019 C57BL/6J ±  kb
    transcript OTTMUST00000142199 VEGA | MGI Sequence Detail 4816 Not Applicable  
    polypeptide OTTMUSP00000074224 VEGA | MGI Sequence Detail 1323 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      156 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 277
      cDNA 276
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15272, MGI:1920820, MGI:2444882
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:11619 Hoog C, et al., Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein. Mol Reprod Dev. 1991 Nov;30(3):173-81
    • Latest
      J:255491 Matsuura T, et al., Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin. Sci Rep. 2017 Sep 29;7(1):12462

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory