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Trf Gene Detail
Summary
  • Symbol
    Trf
  • Name
    transferrin
  • Synonyms
    HP, Tfn
  • Feature Type
    protein coding gene
  • IDs
    MGI:98821
    NCBI Gene: 22041
  • Gene Overview
    MyGene.info: TF
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:103204001-103230444 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26444 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 55.03 cM, cytoband F1-F3
  • Mapping Data
    58 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    TF, transferrin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TF, transferrin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-71p, PRO1557, PRO2086, TFQTL1
  • Links
    NCBI Gene ID: 7018
    neXtProt AC: NX_P02787
    UniProt: P02787

  • Chr Location
    3q22.1; chr3:133661998-133779006 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Trf mouse models; 1 with human TF associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit refractory iron-deficient, hypochromic, microcytic anemia with iron-loading in the liver, pancreas, heart and brain. Mutants usually die by two weeks of age. Heterozygotes show minor increases in iron stores.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024707 VEGA Gene Model | MGI Sequence Detail 26444 C57BL/6J ±  kb
    transcript OTTMUST00000060812 VEGA | MGI Sequence Detail 2339 Not Applicable  
    polypeptide OTTMUSP00000029709 VEGA | MGI Sequence Detail 697 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      166 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 2506
      Genomic 3
      cDNA 2500
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10926, MGD-MRK-15224, MGI:2143006, MGI:96221
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 27
      Diseases 2
      Gene Ontology 24
      Phenotypes 33
    • Earliest
      J:15013 THOMPSON S, et al., Hereditary differences in serum proteins of normal mice. Proc Soc Exp Biol Med. 1954 Nov;87(2):315-7
    • Latest
      J:250166 Liu K, et al., Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Sci Rep. 2016 Feb 16;6:21019

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory