Trf
Gene Detail

Symbol Name ID

Trf transferrin MGI:98821

STS

D9Mit24

Synonyms

HP, Tfn

Feature Type

protein coding gene

Genetic Map

Chromosome 9

55.03 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(58)

Sequence Map

Chr9:103204001-103230444 bp, - strand From VEGA annotation of GRCm38   26444 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transferrin
Gene Tree: Trf

Human homologs

Human Homolog		TF, transferrin
NCBI Gene ID		7018
neXtProt AC		NX_P02787
Human Synonyms		PRO1557, PRO2086, TFQTL1
Human Chr (Location)		3q22.1; chr3:133464977-133497850 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TF

Alleles and phenotypes

All alleles(2) : Targeted(1) Spontaneous(1)
 

Homozygotes for a spontaneous mutation exhibit refractory iron-deficient, hypochromic, microcytic anemia with iron-loading in the liver, pancreas, heart and brain. Mutants usually die by two weeks of age. Heterozygotes show minor increases in iron stores.

 
Human Diseases Modeled Using Mouse Trf (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	actin filament organization, activation of JUN kinase activity, ...
Component	apical plasma membrane, basal part of cell, ...
Function	ferric iron binding, ferric iron transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (73)    Tissues (16)    Images (28)
Theiler Stages: 13, 15, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	27
Northern blot	38
RT-PCR	8

cDNA source data(2496)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(2504) Genomic(3) cDNA(2498) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000024707 (Evidence)
Ensembl Gene Model	ENSMUSG00000032554 (Evidence)
Entrez Gene	22041 (Evidence)
UniGene	37214
DFCI	TC1573635
DoTS	DT.101340660, DT.101340681, DT.101340685, DT.91536892, DT.94232135, DT.94232232, DT.97395449, DT.97395909
NIA Mouse Gene Index	U031257
Consensus CDS Project	CCDS23451.1
International Mouse Knockout Project Status	Trf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024707	VEGA Gene Model | MGI Sequence Detail	26444	C57BL/6J
transcript	OTTMUST00000060812	VEGA | MGI Sequence Detail	2339	Not Applicable
polypeptide	OTTMUSP00000029709	VEGA | MGI Sequence Detail	697	Not Applicable

All sequences(85) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(8) : SNPs(101 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016357	Transferrin
InterPro	IPR001156	Transferrin family
InterPro	IPR018195	Transferrin family, iron binding site
Protein Ontology	PR:000016261	serotransferrin

References

(Earliest) J:15013 THOMPSON S, et al., Hereditary differences in serum proteins of normal mice. Proc Soc Exp Biol Med. 1954 Nov;87(2):315-7
(Latest) J:191529 Lu J, et al., Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr;40(4):307-17.e3
All references(159)

Other accession IDs

MGD-MRK-10926, MGD-MRK-15224, MGI:2143006, MGI:96221