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Trf
Gene Detail
Symbol

Name
ID
Trf
transferrin
MGI:98821
STS
Synonyms
HP, Tfn
Feature Type
protein coding gene
Genetic Map
Chromosome 9
55.03 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(58)
Sequence Map
Chr9:103204001-103230444 bp, - strand
From VEGA annotation of GRCm38

  26444 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TF
Protein SuperFamily: transferrin
Gene Tree: Trf

Human
homologs
TF, transferrin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7018
neXtProt AC: NX_P02787

Human Synonyms: PRO1557, PRO2086, TFQTL1

Human Chr (Location): 3q22.1; chr3:133661998-133779006 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TF

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a spontaneous mutation exhibit refractory iron-deficient, hypochromic, microcytic anemia with iron-loading in the liver, pancreas, heart and brain. Mutants usually die by two weeks of age. Heterozygotes show minor increases in iron stores.
 
Human Diseases Modeled in Mice Using Trf (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trf interacts with 50 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (24 records)
Data Summary: Results (72)    Tissues (17)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
Northern blot 38
Western blot 1
RT-PCR 6
cDNA source data(2497)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(2505) Genomic(3) cDNA(2499) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024707 (Evidence)
Ensembl Gene Model ENSMUSG00000032554 (Evidence)
Entrez Gene 22041 (Evidence)
UniGene 37214
DFCI TC1573635
DoTS DT.101340660, DT.101340681, DT.101340685, DT.91536892, DT.94232135, DT.94232232, DT.97395449, DT.97395909
NIA Mouse Gene Index U031257
Consensus CDS Project CCDS23451.1
International Mouse Phenotyping Consortium Status Trf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024707 VEGA Gene Model | MGI Sequence Detail 26444 C57BL/6J ±  kb
transcript OTTMUST00000060812 VEGA | MGI Sequence Detail 2339 Not Applicable 
polypeptide OTTMUSP00000029709 VEGA | MGI Sequence Detail 697 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(8) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016357 Transferrin
InterPro IPR001156 Transferrin family
InterPro IPR018195 Transferrin family, iron binding site
Protein Ontology PR:000016261 serotransferrin
References
(Earliest) J:15013 THOMPSON S, et al., Hereditary differences in serum proteins of normal mice. Proc Soc Exp Biol Med. 1954 Nov;87(2):315-7
(Latest) J:212210 Gkouvatsos K, et al., Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels. PLoS One. 2014;9(1):e85530
All references(158)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10926, MGD-MRK-15224, MGI:2143006, MGI:96221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory