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Trf
Gene Detail
 Symbol
Name
ID
Trf
transferrin
MGI:98821
STS D9Mit24
Synonyms HP, Tfn
Feature Type protein coding gene
Genetic Map
Chromosome 9
55.03 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(58)
Sequence Map
Chr9:103204001-103230444 bp, - strand
From VEGA annotation of GRCm38

  26444 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transferrin
Gene Tree: Trf

Human
homologs
Human Homolog TF, transferrin
NCBI Gene ID 7018
neXtProt AC  NX_P02787
Human Synonyms  PRO1557, PRO2086, TFQTL1
Human Chr (Location)  3q22.1; chr3:133746133-133779006 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TF
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous mutation exhibit refractory iron-deficient, hypochromic, microcytic anemia with iron-loading in the liver, pancreas, heart and brain. Mutants usually die by two weeks of age. Heterozygotes show minor increases in iron stores.
 
Human Diseases Modeled Using Mouse Trf (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Trf interacts with 50 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process actin filament organization, activation of JUN kinase activity, ...
Component apical plasma membrane, basal part of cell, ...
Function ferric iron binding, ferric iron transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (72)    Tissues (16)    Images (29)
Theiler Stages: 13, 15, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 27
Northern blot 38
Western blot 1
RT-PCR 6
cDNA source data(2497)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(2505) Genomic(3) cDNA(2499) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024707 (Evidence)
Ensembl Gene ModelENSMUSG00000032554 (Evidence)
Entrez Gene22041 (Evidence)
UniGene37214
DFCITC1573635
DoTSDT.91536892, DT.101340660, DT.101340681, DT.101340685, DT.94232135, DT.94232232, DT.97395449, DT.97395909
NIA Mouse Gene IndexU031257
Consensus CDS ProjectCCDS23451.1
International Mouse Knockout Project StatusTrf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024707 VEGA Gene Model | MGI Sequence Detail 26444 C57BL/6J ±  kb
transcript OTTMUST00000060812 VEGA | MGI Sequence Detail 2339 Not Applicable 
polypeptide OTTMUSP00000029709 VEGA | MGI Sequence Detail 697 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(2) UniProt(6)
Polymorphisms RFLP(8) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016357 Transferrin
InterPro IPR001156 Transferrin family
InterPro IPR018195 Transferrin family, iron binding site
Protein Ontology PR:000016261 serotransferrin
References (Earliest) J:15013 THOMPSON S, et al., Hereditary differences in serum proteins of normal mice. Proc Soc Exp Biol Med. 1954 Nov;87(2):315-7
(Latest) J:201826 Ouyang Q, et al., Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron. 2013 Oct 2;80(1):97-112
All references(164)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10926, MGD-MRK-15224, MGI:2143006, MGI:96221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory