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Trap1a Gene Detail
Summary
  • Symbol
    Trap1a
  • Name
    tumor rejection antigen P1A
  • Synonyms
    Tra-P1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:98818
    NCBI Gene: 22037
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:138234432-138238918 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 61.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98818
protein coding gene ChrX:138234432-138238918 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036122
protein coding gene ChrX:136826621-136831110 (+)
A/J MGP_AJ_G0036101
protein coding gene ChrX:136206105-136210990 (+)
AKR/J MGP_AKRJ_G0036025
protein coding gene ChrX:140603870-140608307 (+)
BALB/cJ MGP_BALBcJ_G0036090
protein coding gene ChrX:134567157-134571483 (+)
C3H/HeJ MGP_C3HHeJ_G0035799
protein coding gene ChrX:136849968-136855279 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036615
protein coding gene ChrX:140864242-140868521 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033440
protein coding gene ChrX:127987700-127992333 (+)
CAST/EiJ MGP_CASTEiJ_G0035090
protein coding gene ChrX:117660455-117665888 (+)
CBA/J MGP_CBAJ_G0035776
protein coding gene ChrX:145142550-145148743 (+)
DBA/2J MGP_DBA2J_G0035933
protein coding gene ChrX:135407609-135411999 (+)
FVB/NJ MGP_FVBNJ_G0035867
protein coding gene ChrX:134634588-134639158 (+)
LP/J MGP_LPJ_G0036025
protein coding gene ChrX:137809447-137815395 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035904
protein coding gene ChrX:152676203-152680553 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036651
protein coding gene ChrX:136152454-136157795 (+)
PWK/PhJ MGP_PWKPhJ_G0034783
protein coding gene ChrX:114601741-114606718 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034610
protein coding gene ChrX:118192507-118197438 (+)
WSB/EiJ MGP_WSBEiJ_G0035225
protein coding gene ChrX:134458342-134462739 (+)



Homology
less
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from multigenic genotypes
    13 phenotype references
Mice homozygous for a knock-out allele exhibit increased T cell avidity towards P1A35-43 and increased rejection of P815 tumors with increased survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22037 NCBI Gene Model | MGI Sequence Detail 4487 C57BL/6J ±  kb
transcript NM_011635 RefSeq | MGI Sequence Detail 1178 C57BL/6  
polypeptide P19473 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 40
    Genomic 3
    cDNA 35
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15218, MGD-MRK-15220
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:11176 Van den Eynde B, et al., The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice. J Exp Med. 1991 Jun 1;173(6):1373-84
  • Latest
    J:306349 Li CS, et al., Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development. Cell Mol Immunol. 2017 Aug;14(8):685-692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory