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Hsp90b1 Gene Detail
Summary
  • Symbol
    Hsp90b1
  • Name
    heat shock protein 90, beta (Grp94), member 1
  • Synonyms
    90 kDa, endoplasmin, ERp99, gp96, GRP94, Targ2, Tra1, Tra-1, tumor rejection antigen (gp96) 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98817
    NCBI Gene: 22027
  • Gene Overview
    MyGene.info: HSP90B1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:86690209-86705509 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15301 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 43.05 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    HSP90B1, heat shock protein 90 beta family member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSP90B1, heat shock protein 90 beta family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECGP, GP96, GRP94, HEL35, HEL-S-125m, TRA1
  • Links
    NCBI Gene ID: 7184
    neXtProt AC: NX_P14625
    UniProt: P14625

  • Chr Location
    12q23.3; chr12:103930334-103947930 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 3 genetic backgrounds
    1 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality before somite formation with failure of primitive streak formation, absence of the chorion and amnion, and failure of mesoderm formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020538 VEGA Gene Model | MGI Sequence Detail 15301 C57BL/6J ±  kb
    transcript OTTMUST00000048697 VEGA | MGI Sequence Detail 2825 Not Applicable  
    polypeptide OTTMUSP00000022393 VEGA | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      82 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 950
      Genomic 3
      cDNA 942
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
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    MGD-MRK-15216, MGD-MRK-15219, MGI:1100861
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 24
      Gene Ontology 12
      Phenotypes 35
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257425 Kim DS, et al., GRP94 Is an Essential Regulator of Pancreatic beta-Cell Development, Mass, and Function in Male Mice. Endocrinology. 2018 Feb 1;159(2):1062-1073

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory