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Hsp90b1 Gene Detail
Summary
  • Symbol
    Hsp90b1
  • Name
    heat shock protein 90, beta (Grp94), member 1
  • Synonyms
    90 kDa, endoplasmin, ERp99, gp96, GRP94, Targ2, Tra1, Tra-1, tumor rejection antigen (gp96) 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98817
    NCBI Gene: 22027
  • Gene Overview
    MyGene.info: HSP90B1
Location & Maps
more
  • Sequence Map
    Chr10:86690209-86705509 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15301 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 43.05 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    HSP90B1, heat shock protein 90 beta family member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSP90B1, heat shock protein 90 beta family member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ECGP, GP96, GRP94, HEL35, HEL-S-125m, TRA1
  • Links
    NCBI Gene ID: 7184
    neXtProt AC: NX_P14625

  • Chr Location
    12q24.2-q24.3; chr12:103930334-103947930 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 3 genetic backgrounds
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Targeted
    7
  • Genomic Mutations
    1 involving Hsp90b1
  • Incidental Mutations
Mice homozygous for a null mutation display embryonic lethality before somite formation with failure of primitive streak formation, absence of the chorion and amnion, and failure of mesoderm formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020538 VEGA Gene Model | MGI Sequence Detail 15301 C57BL/6J ±  kb
transcript OTTMUST00000048697 VEGA | MGI Sequence Detail 2825 Not Applicable  
polypeptide OTTMUSP00000022393 VEGA | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    82 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000008801 endoplasmin
  • InterPro Domains
    IPR019805 Heat shock protein Hsp90, conserved site
    IPR001404 Heat shock protein Hsp90 family
    IPR020575 Heat shock protein Hsp90, N-terminal
    IPR003594 Histidine kinase-like ATPase, C-terminal domain
    IPR020568 Ribosomal protein S5 domain 2-type fold
Molecular
Reagents
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  • All nucleic 950
    Genomic 3
    cDNA 942
    Primer pair 2
    Other 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15216, MGD-MRK-15219, MGI:1100861
References
more
  • Summaries
    All 116
    Developmental Gene Expression 19
    Gene Ontology 12
    Phenotypes 32
  • Earliest
    J:17607 Mazzarella RA, et al., ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94). J Biol Chem. 1987 Jun 25;262(18):8875-83
  • Latest
    J:229513 Shen J, et al., Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget. 2016 Feb 17;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory