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Gene Detail
heat shock protein 90, beta (Grp94), member 1
Synonyms 90 kDa, endoplasmin, ERp99, gp96, GRP94, Targ2, Tra1, Tra-1, tumor rejection antigen (gp96) 1
Feature Type protein coding gene
Genetic Map
Chromosome 10
43.05 cM
Detailed Genetic Map ± 1 cM

Mapping data(20)
Sequence Map
Chr10:86690209-86705509 bp, - strand
From VEGA annotation of GRCm38

  15301 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:2476  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: heat shock protein, HSP90/HTPG types
Gene Tree: Hsp90b1

Human Homolog HSP90B1, heat shock protein 90kDa beta (Grp94), member 1
NCBI Gene ID 7184
neXtProt AC  NX_P14625
Human Synonyms  ECGP, GP96, GRP94, HEL35, HEL-S-125m, TRA1
Human Chr (Location)  12q24.2-q24.3; chr12:103930334-103947930 (+)  GRCh38
alleles, and
All mutations/alleles(23) : Gene trapped(16) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a null mutation display embryonic lethality before somite formation with failure of primitive streak formation, absence of the chorion and amnion, and failure of mesoderm formation.
Hsp90b1 interacts with 134 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
All GO classifications: (33 annotations)
Process actin rod assembly, cellular response to ATP, ...
Component cytosol, endoplasmic reticulum, ...
Function ATP binding, low-density lipoprotein particle receptor binding, ...
External Resources: FuncBase
Literature Summary: (18 records)
Data Summary: Results (53)    Tissues (14)    Images (20)
Theiler Stages: 17, 22, 23, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 25
Northern blot 2
Western blot 20
cDNA source data(940)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(947) Genomic(3) cDNA(941) Other(3)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000020538 (Evidence)
Ensembl Gene ModelENSMUSG00000020048 (Evidence)
Entrez Gene22027 (Evidence)
DFCITC1573664, TC1714042
NIA Mouse Gene IndexU032093
Consensus CDS ProjectCCDS36019.1
International Mouse Knockout Project StatusHsp90b1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020538 VEGA Gene Model | MGI Sequence Detail 15301 C57BL/6J ±  kb
transcript OTTMUST00000048697 VEGA | MGI Sequence Detail 2825 Not Applicable 
polypeptide OTTMUSP00000022393 VEGA | MGI Sequence Detail 802 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(2) UniProt(9)
Polymorphisms RFLP(3) : SNPs within 2kb(83 from dbSNP Build 137)    SNPs within 2kb including multiple locations(85)
InterPro IPR001404 Heat shock protein Hsp90
InterPro IPR019805 Heat shock protein Hsp90, conserved site
InterPro IPR020575 Heat shock protein Hsp90, N-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000008801 endoplasmin
References (Earliest) J:17607 Mazzarella RA, et al., ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94). J Biol Chem. 1987 Jun 25;262(18):8875-83
(Latest) J:212079 Zhu G, et al., Differential requirement of GRP94 and GRP78 in mammary gland development. Sci Rep. 2014;4:5390
All references(112)
accession IDs
MGD-MRK-15216, MGD-MRK-15219, MGI:1100861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory