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Crisp2 Gene Detail
Summary
  • Symbol
    Crisp2
  • Name
    cysteine-rich secretory protein 2
  • Synonyms
    CRISP-2, GAPDL5, Tpx1, Tpx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98815
    NCBI Gene: 22024
  • Gene Overview
    MyGene.info: CRISP2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:40764734-40794146 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.54 cM
  • Mapping Data
    12 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98815
protein coding gene Chr17:40764020-40807003 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023760
protein coding gene Chr17:41569099-41611182 (-)
A/J MGP_AJ_G0023718
protein coding gene Chr17:40620453-40658711 (-)
AKR/J MGP_AKRJ_G0023689
protein coding gene Chr17:40798720-40836547 (-)
BALB/cJ MGP_BALBcJ_G0023722
protein coding gene Chr17:40549439-40588681 (-)
C3H/HeJ MGP_C3HHeJ_G0023486
protein coding gene Chr17:41480316-41521495 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024164
protein coding gene Chr17:43430759-43469401 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021615
protein coding gene Chr17:37714679-37753728 (-)
CAST/EiJ MGP_CASTEiJ_G0022967
protein coding gene Chr17:41492141-41530823 (-)
CBA/J MGP_CBAJ_G0023462
protein coding gene Chr17:44960680-45003833 (-)
DBA/2J MGP_DBA2J_G0023588
protein coding gene Chr17:39431417-39467722 (-)
FVB/NJ MGP_FVBNJ_G0023555
protein coding gene Chr17:39076298-39111687 (-)
LP/J MGP_LPJ_G0023669
protein coding gene Chr17:42214229-42249454 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023584
protein coding gene Chr17:44401068-44444055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024210
protein coding gene Chr17:41118893-41160613 (-)
PWK/PhJ MGP_PWKPhJ_G0022712
protein coding gene Chr17:38792038-38829123 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022527
protein coding gene Chr17:38095638-38134375 (-)
WSB/EiJ MGP_WSBEiJ_G0023032
protein coding gene Chr17:41676599-41716308 (-)



Homology
more
  • Human Ortholog
    CRISP2, cysteine rich secretory protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CRISP2, cysteine rich secretory protein 2
    Orthology source: HomoloGene
  • Synonyms
    CRISP-2, CT36, GAPDL5, TPX1, TSP1
  • Links
    NCBI Gene ID: 7180
    neXtProt AC: NX_P16562
    UniProt: P16562

  • Chr Location
    6p12.3; chr6:49676665-49714198 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a hypomorphic allele display reduced fertility with impaired acrosome reaction and reduced sperm motility. Fertility in female homozygous mice is not impaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22024 NCBI Gene Model | MGI Sequence Detail 29413 C57BL/6J ±  kb
transcript NM_009420 RefSeq | MGI Sequence Detail 1469 C57BL/6  
polypeptide P16563 UniProt | EBI | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    Genomic 7
    cDNA 40

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15211, MGD-MRK-15213
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:8695 Kasahara M, et al., Random cloning of genes from mouse chromosome 17. Proc Natl Acad Sci U S A. 1987 May;84(10):3325-8
  • Latest
    J:273472 Lim S, et al., CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility. Endocrinology. 2019 Apr 1;160(4):915-924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory