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Tpo
Gene Detail
Symbol

Name
ID
Tpo
thyroid peroxidase
MGI:98813
Feature Type
protein coding gene
Genetic Map
Chromosome 12
13.00 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr12:30054659-30132624 bp, - strand
From VEGA annotation of GRCm38

  77966 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TPO
Protein SuperFamily: thyroid peroxidase precursor
Gene Tree: Tpo

Human
homologs
TPO, thyroid peroxidase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7173
neXtProt AC: NX_P07202

Human Synonyms: MSA, TDH2A, TPX

Human Chr (Location): 2p25; chr2:1413461-1542727 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TPO

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice with a missense mutation exhibit hypothyroid dwarfism, including a goiter with colloid deficiency and abnormal follicle epithelium, reduced hematocrit and red blood cells and a lifespan of about 3 months.
 
Interactions
Tpo interacts with 125 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process embryonic hemopoiesis, hormone biosynthetic process, ...
Component cell surface, extracellular space, ...
Function calcium ion binding, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (119)    Tissues (99)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 115
RT-PCR 4
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(15) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025268 (Evidence)
Ensembl Gene Model ENSMUSG00000020673 (Evidence)
Entrez Gene 22018 (Evidence)
UniGene 4991
DFCI TC1587506, TC1596658
DoTS DT.102548854, DT.87040816
NIA Mouse Gene Index U033872
EC 1.11.1.8
Consensus CDS Project CCDS25857.1
International Mouse Phenotyping Consortium Status Tpo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025268 VEGA Gene Model | MGI Sequence Detail 77966 C57BL/6J ±  kb
transcript OTTMUST00000062199 VEGA | MGI Sequence Detail 3299 Not Applicable 
polypeptide OTTMUSP00000030629 VEGA | MGI Sequence Detail 914 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(11) UniProt(3)
Polymorphisms
RFLP(6) : SNPs within 2kb(898 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR010255 Haem peroxidase
InterPro IPR019791 Haem peroxidase, animal
InterPro IPR000436 Sushi/SCR/CCP domain
InterPro IPR029589 Thyroid peroxidase
Protein Ontology PR:000016584 thyroid peroxidase
References
(Earliest) J:42190 Burrow GN, et al., Normal peroxidase activity in Pendred's syndrome. J Clin Endocrinol Metab. 1973 Mar;36(3):522-30
(Latest) J:220108 Marotta P, et al., The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. Mol Cell Endocrinol. 2014 Oct;396(1-2):26-36
All references(54)
Other
accession IDs
MGD-MRK-15209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory