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Tpo Gene Detail
Summary
  • Symbol
    Tpo
  • Name
    thyroid peroxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98813
    NCBI Gene: 22018
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:30054659-30132624 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 13.00 cM, cytoband C
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    884 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98813
protein coding gene Chr12:30054659-30132984 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019650
protein coding gene Chr12:27947012-28019430 (-)
A/J MGP_AJ_G0019617
protein coding gene Chr12:27176776-27247437 (-)
AKR/J MGP_AKRJ_G0019588
protein coding gene Chr12:28068610-28139305 (-)
BALB/cJ MGP_BALBcJ_G0019594
protein coding gene Chr12:27430687-27499309 (-)
C3H/HeJ MGP_C3HHeJ_G0019398
protein coding gene Chr12:27918910-27988216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020041
protein coding gene Chr12:28829739-28915087 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017666
protein coding gene Chr12:26515419-26584827 (-)
CAST/EiJ MGP_CASTEiJ_G0018953
protein coding gene Chr12:22912895-22990653 (-)
CBA/J MGP_CBAJ_G0019369
protein coding gene Chr12:29787930-29860644 (-)
DBA/2J MGP_DBA2J_G0019483
protein coding gene Chr12:27021325-27094310 (-)
FVB/NJ MGP_FVBNJ_G0019474
protein coding gene Chr12:26833407-26903696 (-)
LP/J MGP_LPJ_G0019553
protein coding gene Chr12:28040768-28109820 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019509
protein coding gene Chr12:29393101-29462582 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020081
protein coding gene Chr12:27593539-27676587 (-)
PWK/PhJ MGP_PWKPhJ_G0018720
protein coding gene Chr12:21745120-21820131 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018508
protein coding gene Chr12:22190822-22261958 (-)
WSB/EiJ MGP_WSBEiJ_G0019004
protein coding gene Chr12:27806346-27881289 (-)



Homology
more
  • Human Ortholog
    TPO, thyroid peroxidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPO, thyroid peroxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSA, TDH2A, TPX
  • Links
    NCBI Gene ID: 7173
    neXtProt AC: NX_P07202
    UniProt: P07202

  • Chr Location
    2p25.3; chr2:1413461-1542729 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tpo mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice with a missense mutation exhibit hypothyroid dwarfism, including a goiter with colloid deficiency and abnormal follicle epithelium, reduced hematocrit and red blood cells and a lifespan of about 3 months.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020673 Ensembl Gene Model | MGI Sequence Detail 77966 C57BL/6J ±  kb
    transcript ENSMUST00000021005 Ensembl | MGI Sequence Detail 3299 Not Applicable  
    polypeptide ENSMUSP00000021005 Ensembl | MGI Sequence Detail 914 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 16
      Primer pair 2
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15209
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:42190 Burrow GN, et al., Normal peroxidase activity in Pendred's syndrome. J Clin Endocrinol Metab. 1973 Mar;36(3):522-30
    • Latest
      J:257406 Metwalli KA, et al., Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development. J Dent Res. 2018 Feb;97(2):226-236

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    01/15/2019
    MGI 6.13
    The Jackson Laboratory