Tpo
Gene Detail

Symbol Name ID

Tpo thyroid peroxidase MGI:98813

Feature Type

protein coding gene

Genetic Map

Chromosome 12

13.00 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr12:30054659-30132624 bp, - strand From VEGA annotation of GRCm38   77966 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thyroid peroxidase precursor
Gene Tree: Tpo

Human homologs

Human Homolog		TPO, thyroid peroxidase
NCBI Gene ID		7173
neXtProt AC		NX_P07202
Human Synonyms		MSA, TDH2A, TPX
Human Chr (Location)		2p25; chr2:1417233-1546499 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TPO

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Spontaneous(1)
 

Homozygous mice with a missense mutation exhibit hypothyroid dwarfism, including a goiter with colloid deficiency and abnormal follicle epithelium, reduced hematocrit and red blood cells and a lifespan of about 3 months.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	embryonic hemopoiesis, hormone biosynthetic process, ...
Component	cell surface, integral to membrane, ...
Function	calcium ion binding, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (119)    Tissues (99)    Images (19)
Theiler Stages: 22, 23, 26

Assay Type	Results
RNA in situ	115
RT-PCR	4

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(15) Primer pair(1) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000025268 (Evidence)
Ensembl Gene Model	ENSMUSG00000020673 (Evidence)
Entrez Gene	22018 (Evidence)
UniGene	4991
DFCI	TC1587506, TC1596658
DoTS	DT.102548854, DT.87040816
NIA Mouse Gene Index	U033872
EC	1.11.1.8
Consensus CDS Project	CCDS25857.1
International Mouse Knockout Project Status	Tpo

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025268	VEGA Gene Model | MGI Sequence Detail	77966	C57BL/6J
transcript	OTTMUST00000062199	VEGA | MGI Sequence Detail	3299	Not Applicable
polypeptide	OTTMUSP00000030629	VEGA | MGI Sequence Detail	914	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(6) : SNPs(521 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016060	Complement control module
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR010255	Haem peroxidase
InterPro	IPR002007	Haem peroxidase, animal
InterPro	IPR019791	Haem peroxidase, animal, subgroup
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000016584	thyroid peroxidase

References

(Earliest) J:42190 Burrow GN, et al., Normal peroxidase activity in Pendred's syndrome. J Clin Endocrinol Metab. 1973 Mar;36(3):522-30
(Latest) J:181140 Frezzetti D, et al., The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One. 2011;6(11):e27648
All references(53)

Other accession IDs

MGD-MRK-15209