Tpm2
Gene Detail

Symbol Name ID

Tpm2 tropomyosin 2, beta MGI:98810

Synonyms

Tpm-2, Trop-2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

23.05 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:43514711-43523765 bp, - strand From VEGA annotation of GRCm38   9055 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tpm2

Human homologs

Human Homolog		TPM2, tropomyosin 2 (beta)
NCBI Gene ID		7169
neXtProt AC		NX_P07951
Human Synonyms		AMCD1, DA1, DA2B, NEM4, TMSB
Human Chr (Location)		9p13; chr9:35681990-35690053 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human TPM2

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	muscle contraction, regulation of ATPase activity
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (86)    Tissues (74)    Images (8)
Theiler Stages: 23, 24, 26, 28

Assay Type	Results
RNA in situ	79
Western blot	7

cDNA source data(220)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(223) Genomic(1) cDNA(222)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006959 (Evidence)
Ensembl Gene Model	ENSMUSG00000028464 (Evidence)
Entrez Gene	22004 (Evidence)
UniGene	646
DFCI	TC1574818, TC1581419, TC1591984, TC1705464
DoTS	DT.101285596, DT.94358880, DT.97383083
NIA Mouse Gene Index	U024989
Consensus CDS Project	CCDS18100.1
International Mouse Knockout Project Status	Tpm2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006959	VEGA Gene Model | MGI Sequence Detail	9055	C57BL/6J
transcript	OTTMUST00000016118	VEGA | MGI Sequence Detail	2175	Not Applicable
polypeptide	OTTMUSP00000007393	VEGA | MGI Sequence Detail	284	Not Applicable

All sequences(59) RefSeq(6) UniProt(7)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000533	Tropomyosin
Protein Ontology	PR:000016580	tropomyosin beta chain

References

(Earliest) J:9738 Takenaga K, et al., Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2. Mol Cell Biol. 1988 Dec;8(12):5561-5
(Latest) J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
All references(57)

Other accession IDs

MGD-MRK-15203, MGD-MRK-15206, MGD-MRK-15241