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Tpi1
Gene Detail
Symbol

Name
ID
Tpi1
triosephosphate isomerase 1
MGI:98797
Synonyms
Tpi-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(33)
Sequence Map
Chr6:124810586-124814296 bp, - strand
From VEGA annotation of GRCm38

  3711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TPI1
Protein SuperFamily: triose-phosphate isomerase
Gene Tree: Tpi1

Human
homologs
TPI1, triosephosphate isomerase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7167
neXtProt AC: NX_P60174

Human Synonyms: HEL-S-49, TIM, TPI, TPID

Human Chr (Location): 12p13; chr12:6867420-6870946 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TPI1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(4) Chemically induced (other)(2) Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mutants die at postimplantation stage. Heterozygotes are normal, but with 50% of normal enzyme activity. Mice heterozygous or homozygous for a hyperactivity allele are otherwise normal. Mice homozygous for a chemically induced allele exhibit symptoms of hemolytic anemia.
 
Interactions
Tpi1 interacts with 81 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process embryo development, gluconeogenesis, ...
Component cytosol, extracellular exosome, ...
Function catalytic activity, isomerase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (192)    Tissues (153)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 182
Northern blot 8
RT-PCR 2
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tpi1 ; ZFIN tpi1a, tpi1b    NEW 
Molecular
reagents
All nucleic(32) Genomic(4) cDNA(24) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017534 (Evidence)
Ensembl Gene Model ENSMUSG00000023456 (Evidence)
Entrez Gene 21991 (Evidence)
DFCI TC1573704, TC1617989, TC1672720
DoTS DT.101361611, DT.101361797, DT.91430834, DT.94336363, DT.97412889
NIA Mouse Gene Index U027850, U076225
EC 5.3.1.1
Consensus CDS Project CCDS20530.2
International Mouse Phenotyping Consortium Status Tpi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017534 VEGA Gene Model | MGI Sequence Detail 3711 C57BL/6J ±  kb
transcript OTTMUST00000042601 VEGA | MGI Sequence Detail 1607 Not Applicable 
polypeptide OTTMUSP00000019147 VEGA | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(7) : SNPs within 2kb(17 from dbSNP Build 137)    SNPs within 2kb including multiple locations(19)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR000652 Triosephosphate isomerase
InterPro IPR020861 Triosephosphate isomerase, active site
InterPro IPR022896 Triosephosphate isomerase, bacterial/eukaryotic
Protein Ontology PR:000016577 triosephosphate isomerase
References
(Earliest) J:5946 Kozak CA, et al., Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet. 1977 Mar;3(2):121-33
(Latest) J:212391 Uslu VV, et al., Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014 Jul;46(7):753-8
All references(75)
Other
accession IDs
MGD-MRK-15179, MGD-MRK-15180, MGI:2141384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory