Tpi1
Gene Detail

Symbol Name ID

Tpi1 triosephosphate isomerase 1 MGI:98797

Synonyms

Tpi-1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(33)

Sequence Map

Chr6:124810586-124814296 bp, - strand From VEGA annotation of GRCm38   3711 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128432  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: triose-phosphate isomerase
Gene Tree: Tpi1

Human homologs

Human Homolog		TPI1, triosephosphate isomerase 1
NCBI Gene ID		7167
neXtProt AC		NX_P60174
Human Synonyms		TIM, TPI
Human Chr (Location)		12p13; chr12:6976584-6980110 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TPI1

Alleles and phenotypes

All alleles(11) : Targeted(3) Gene trapped(2) Chemically induced(6)
 

Homozygous null mutants die at postimplantation stage. Heterozygotes are normal, but with 50% of normal enzyme activity. Mice heterozygous or homozygous for a hyperactivity allele are otherwise normal. Mice homozygous for a chemically induced allele exhibit symptoms of hemolytic anemia.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	embryo development, gluconeogenesis, ...
Function	catalytic activity, isomerase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (112)    Images (23)
Theiler Stages: 15, 17, 22, 28

Assay Type	Results
RNA in situ	140
Northern blot	8
RT-PCR	2

cDNA source data(884)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(894) Genomic(4) cDNA(886) Primer pair(2) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017534 (Evidence)
Ensembl Gene Model	ENSMUSG00000023456 (Evidence)
Entrez Gene	21991 (Evidence)
UniGene	4222
DFCI	TC1573704, TC1617989, TC1672720
DoTS	DT.101361611, DT.101361797, DT.91430834, DT.94336363, DT.97412889
NIA Mouse Gene Index	U027850, U076225
EC	5.3.1.1
Consensus CDS Project	CCDS20530.2
International Mouse Knockout Project Status	Tpi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017534	VEGA Gene Model | MGI Sequence Detail	3711	C57BL/6J
transcript	OTTMUST00000042601	VEGA | MGI Sequence Detail	1607	Not Applicable
polypeptide	OTTMUSP00000019147	VEGA | MGI Sequence Detail	299	Not Applicable

All sequences(64) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(7) : SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR000652	Triosephosphate isomerase
InterPro	IPR020861	Triosephosphate isomerase, active site
InterPro	IPR022896	Triosephosphate isomerase, bacterial/eukaryotic
Protein Ontology	PR:000016577	triosephosphate isomerase

References

(Earliest) J:5946 Kozak CA, et al., Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet. 1977 Mar;3(2):121-33
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(74)

Other accession IDs

MGD-MRK-15179, MGD-MRK-15180, MGI:2141384