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Tpi1
Gene Detail
Symbol

Name
ID
Tpi1
triosephosphate isomerase 1
MGI:98797
Synonyms
Tpi-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(33)
Sequence Map
Chr6:124810586-124814296 bp, - strand
From VEGA annotation of GRCm38

  3711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: triose-phosphate isomerase
Gene Tree: Tpi1

Human
homologs
Human Homolog TPI1, triosephosphate isomerase 1
NCBI Gene ID 7167
neXtProt AC  NX_P60174
Human Synonyms  HEL-S-49, TIM, TPI, TPID
Human Chr (Location)  12p13; chr12:6867420-6870946 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TPI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(4) Chemically induced (other)(2) Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mutants die at postimplantation stage. Heterozygotes are normal, but with 50% of normal enzyme activity. Mice heterozygous or homozygous for a hyperactivity allele are otherwise normal. Mice homozygous for a chemically induced allele exhibit symptoms of hemolytic anemia.
 
Interactions
Tpi1 interacts with 82 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process embryo development, gluconeogenesis, ...
Component extracellular space, extracellular vesicular exosome, ...
Function catalytic activity, isomerase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (192)    Tissues (153)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 182
Northern blot 8
RT-PCR 2
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(4) cDNA(24) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017534 (Evidence)
Ensembl Gene ModelENSMUSG00000023456 (Evidence)
Entrez Gene21991 (Evidence)
DFCITC1573704, TC1617989, TC1672720
DoTSDT.101361611, DT.101361797, DT.91430834, DT.94336363, DT.97412889
NIA Mouse Gene IndexU027850, U076225
EC5.3.1.1
Consensus CDS ProjectCCDS20530.2
International Mouse Knockout Project StatusTpi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017534 VEGA Gene Model | MGI Sequence Detail 3711 C57BL/6J ±  kb
transcript OTTMUST00000042601 VEGA | MGI Sequence Detail 1607 Not Applicable 
polypeptide OTTMUSP00000019147 VEGA | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(7) : SNPs within 2kb(17 from dbSNP Build 137)    SNPs within 2kb including multiple locations(19)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR000652 Triosephosphate isomerase
InterPro IPR020861 Triosephosphate isomerase, active site
InterPro IPR022896 Triosephosphate isomerase, bacterial/eukaryotic
Protein Ontology PR:000016577 triosephosphate isomerase
References
(Earliest) J:5946 Kozak CA, et al., Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet. 1977 Mar;3(2):121-33
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(77)
Other
accession IDs
MGD-MRK-15179, MGD-MRK-15180, MGI:2141384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory