About   Help   FAQ
Tpi1 Gene Detail
Summary
  • Symbol
    Tpi1
  • Name
    triosephosphate isomerase 1
  • Synonyms
    Tpi-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98797
    NCBI Gene: 21991
  • Gene Overview
    MyGene.info: TPI1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124810592-124814296 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98797
protein coding gene Chr6:124810586-124814296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031269
protein coding gene Chr6:128117372-128121059 (-)
A/J MGP_AJ_G0031239
protein coding gene Chr6:123295894-123300681 (-)
AKR/J MGP_AKRJ_G0031167
protein coding gene Chr6:126660367-126664216 (-)
BALB/cJ MGP_BALBcJ_G0031247
protein coding gene Chr6:122896508-122900352 (-)
C3H/HeJ MGP_C3HHeJ_G0030970
protein coding gene Chr6:126708335-126712875 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031703
protein coding gene Chr6:131501186-131504752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028853
protein coding gene Chr6:120506884-120510591 (-)
CAST/EiJ MGP_CASTEiJ_G0030351
protein coding gene Chr6:126910532-126916692 (-)
CBA/J MGP_CBAJ_G0030931
protein coding gene Chr6:136531391-136536210 (-)
DBA/2J MGP_DBA2J_G0031087
protein coding gene Chr6:122223595-122227161 (-)
FVB/NJ MGP_FVBNJ_G0031037
protein coding gene Chr6:121125599-121129496 (-)
LP/J MGP_LPJ_G0031167
protein coding gene Chr6:128288195-128291976 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031075
protein coding gene Chr6:140591675-140595362 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031738
protein coding gene Chr6:126555630-126558633 (-)
PWK/PhJ MGP_PWKPhJ_G0030066
protein coding gene Chr6:120451741-120457974 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029895
protein coding gene Chr6:124634054-124639281 (-)
WSB/EiJ MGP_WSBEiJ_G0030436
protein coding gene Chr6:126913911-126917598 (-)



Homology
more
  • Human Ortholog
    TPI1, triosephosphate isomerase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPI1, triosephosphate isomerase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-S-49, TIM, TPI, TPID
  • Links
    NCBI Gene ID: 7167
    neXtProt AC: NX_P60174
    UniProt: P60174

  • Chr Location
    12p13.31; chr12:6867420-6870946 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tpi1 mouse models; 1 with human TPI1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 8 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die at postimplantation stage. Heterozygotes are normal, but with 50% of normal enzyme activity. Mice heterozygous or homozygous for a hyperactivity allele are otherwise normal. Mice homozygous for a chemically induced allele exhibit symptoms of hemolytic anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21991 NCBI Gene Model | MGI Sequence Detail 3705 C57BL/6J ±  kb
    transcript NM_009415 RefSeq | MGI Sequence Detail 1601 C57BL/6  
    polypeptide P17751 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 4
      cDNA 25
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15179, MGD-MRK-15180, MGI:2141384
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:5946 Kozak CA, et al., Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet. 1977 Mar;3(2):121-33
    • Latest
      J:263104 Conway AJ, et al., Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency. Dis Model Mech. 2018 May 21;11(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory