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Tpi1 Gene Detail
Summary
  • Symbol
    Tpi1
  • Name
    triosephosphate isomerase 1
  • Synonyms
    Tpi-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98797
    NCBI Gene: 21991
  • Gene Overview
    MyGene.info: TPI1
Location & Maps
more
  • Sequence Map
    Chr6:124810586-124814296 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3711 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    33 experiments
Homology
more
  • Human Ortholog
    TPI1, triosephosphate isomerase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPI1, triosephosphate isomerase 1
    Orthology source: HomoloGene
  • Synonyms
    HEL-S-49, TIM, TPI, TPID
  • Links
    NCBI Gene ID: 7167
    neXtProt AC: NX_P60174

  • Chr Location
    12p13; chr12:6867420-6870946 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TPI1 associations

Human Disease Mouse Models
       Triosephosphate Isomerase Deficiency; TPID   OMIM: 615512
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 7 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    3
  • Incidental Mutations
Homozygous null mutants die at postimplantation stage. Heterozygotes are normal, but with 50% of normal enzyme activity. Mice heterozygous or homozygous for a hyperactivity allele are otherwise normal. Mice homozygous for a chemically induced allele exhibit symptoms of hemolytic anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017534 VEGA Gene Model | MGI Sequence Detail 3711 C57BL/6J ±  kb
transcript OTTMUST00000042601 VEGA | MGI Sequence Detail 1607 Not Applicable  
polypeptide OTTMUSP00000019147 VEGA | MGI Sequence Detail 299 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016577 triosephosphate isomerase
  • EC
  • InterPro Domains
    IPR013785 Aldolase-type TIM barrel
    IPR000652 Triosephosphate isomerase
    IPR020861 Triosephosphate isomerase, active site
    IPR022896 Triosephosphate isomerase, bacterial/eukaryotic
Molecular
Reagents
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  • All nucleic 32
    Genomic 4
    cDNA 24
    Primer pair 2
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15179, MGD-MRK-15180, MGI:2141384
References
more
  • Summaries
    All 73
    Developmental Gene Expression 9
    Gene Ontology 13
    Phenotypes 13
  • Earliest
    J:5946 Kozak CA, et al., Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet. 1977 Mar;3(2):121-33
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory