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Top2a Gene Detail
Summary
  • Symbol
    Top2a
  • Name
    topoisomerase (DNA) II alpha
  • Synonyms
    DNA Topoisomerase II alpha, Top-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98790
    NCBI Gene: 21973
  • Gene Overview
    MyGene.info: TOP2A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98992943-99024189 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98790
protein coding gene Chr11:98992943-99024205 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019080
protein coding gene Chr11:101624747-101656902 (-)
A/J MGP_AJ_G0019048
protein coding gene Chr11:97356001-97387904 (-)
AKR/J MGP_AKRJ_G0019018
protein coding gene Chr11:100369237-100401929 (-)
BALB/cJ MGP_BALBcJ_G0019022
protein coding gene Chr11:97849480-97880898 (-)
C3H/HeJ MGP_C3HHeJ_G0018835
protein coding gene Chr11:100519458-100551475 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019473
protein coding gene Chr11:104756654-104791916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017105
protein coding gene Chr11:94911623-94945443 (-)
CAST/EiJ MGP_CASTEiJ_G0018389
protein coding gene Chr11:101508073-101539405 (-)
CBA/J MGP_CBAJ_G0018806
protein coding gene Chr11:109106898-109141677 (-)
DBA/2J MGP_DBA2J_G0018914
protein coding gene Chr11:96916902-96947911 (-)
FVB/NJ MGP_FVBNJ_G0018903
protein coding gene Chr11:96432369-96464509 (-)
LP/J MGP_LPJ_G0018984
protein coding gene Chr11:102082388-102118591 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018930
protein coding gene Chr11:108787237-108821575 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019513
protein coding gene Chr11:100729675-100761815 (-)
PWK/PhJ MGP_PWKPhJ_G0018160
protein coding gene Chr11:97967741-97999581 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017949
protein coding gene Chr11:100481381-100513845 (-)
WSB/EiJ MGP_WSBEiJ_G0018438
protein coding gene Chr11:100687915-100728325 (-)



Homology
more
  • Human Ortholog
    TOP2A, DNA topoisomerase II alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP2A, DNA topoisomerase II alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TOP2, TP2A
  • Links
    NCBI Gene ID: 7153
    neXtProt AC: NX_P11388
    UniProt: P11388

  • Chr Location
    17q21.2; chr17:40388521-40417950 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020914 Ensembl Gene Model | MGI Sequence Detail 31247 C57BL/6J ±  kb
transcript ENSMUST00000068031 Ensembl | MGI Sequence Detail 5221 Not Applicable  
polypeptide ENSMUSP00000068896 Ensembl | MGI Sequence Detail 1528 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016544 DNA topoisomerase 2-alpha
  • EC
  • InterPro Domains
    IPR031660 C-terminal associated domain of TOPRIM
    IPR034157 DNA topoisomerase 2, TOPRIM domain
    IPR001241 DNA topoisomerase, type IIA
    IPR018522 DNA topoisomerase, type IIA, conserved site
    IPR013760 DNA topoisomerase, type IIA-like domain superfamily
    IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
    IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
    IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal
    IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
    IPR012542 DTHCT
    IPR003594 Histidine kinase/HSP90-like ATPase
    IPR036890 Histidine kinase/HSP90-like ATPase superfamily
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
    IPR006171 TOPRIM domain
    IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
Molecular
Reagents
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  • All nucleic 605
    Genomic 1
    cDNA 602
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15166, MGD-MRK-15169
References
more
  • Summaries
    All 83
    Developmental Gene Expression 13
    Gene Ontology 18
    Phenotypes 13
  • Earliest
    J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
  • Latest
    J:251537 Pett L, et al., Modulation of topoisomerase IIalpha expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide. Biochim Biophys Acta. 2017 May;1860(5):617-629

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory