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Top2a Gene Detail
Summary
  • Symbol
    Top2a
  • Name
    topoisomerase (DNA) II alpha
  • Synonyms
    DNA Topoisomerase II alpha, Top-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98790
    NCBI Gene: 21973
  • Gene Overview
    MyGene.info: TOP2A
Location & Maps
more
  • Sequence Map
    Chr11:98992943-99024189 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31247 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.91 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TOP2A, topoisomerase (DNA) II alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP2A, topoisomerase (DNA) II alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TOP2, TP2A
  • Links
    NCBI Gene ID: 7153
    neXtProt AC: NX_P11388

  • Chr Location
    17q21.2; chr17:40388521-40417950 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    48
  • Gene trapped
    46
  • Targeted
    2
  • Genomic Mutations
    1 involving Top2a
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006446 VEGA Gene Model | MGI Sequence Detail 31247 C57BL/6J ±  kb
transcript OTTMUST00000014727 VEGA | MGI Sequence Detail 5221 Not Applicable  
polypeptide OTTMUSP00000006845 VEGA | MGI Sequence Detail 1528 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    170 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016544 DNA topoisomerase 2-alpha
  • EC
  • InterPro Domains
    IPR024946 Arginine repressor C-terminal-like domain
    IPR031660 C-terminal associated domain of TOPRIM
    IPR028466 DNA topoisomerase II-alpha
    IPR001241 DNA topoisomerase, type IIA
    IPR013759 DNA topoisomerase, type IIA, central domain
    IPR018522 DNA topoisomerase, type IIA, conserved site
    IPR013760 DNA topoisomerase, type IIA-like domain
    IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
    IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
    IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
    IPR012542 DTHCT
    IPR003594 Histidine kinase-like ATPase, C-terminal domain
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
    IPR006171 Toprim domain
    IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain
Molecular
Reagents
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  • All nucleic 604
    Genomic 1
    cDNA 602
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15166, MGD-MRK-15169
References
more
  • Summaries
    All 60
    Developmental Gene Expression 8
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
  • Latest
    J:217257 Ogawa Y, et al., Shikonin shortens the circadian period: possible involvement of Top2 inhibition. Biochem Biophys Res Commun. 2014 Jan 3;443(1):339-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory