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Top1 Gene Detail
Summary
  • Symbol
    Top1
  • Name
    topoisomerase (DNA) I
  • Synonyms
    D130064I21Rik, Top-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98788
    NCBI Gene: 21969
  • Gene Overview
    MyGene.info: TOP1
Location & Maps
more
  • Sequence Map
    Chr2:160645888-160722764 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      76877 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 80.96 cM, cytoband H2-3
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    TOP1, topoisomerase (DNA) I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP1, topoisomerase (DNA) I
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TOPI
  • Links
    NCBI Gene ID: 7150
    neXtProt AC: NX_P11387

  • Chr Location
    20q12-q13.1; chr20:41028822-41124487 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A homozygous mutation resulted in early embryonic lethality at the 4 to 16 cell stage of development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    5
  • cDNA Data
    24
  • Literature Summary
    5
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001178 VEGA Gene Model | MGI Sequence Detail 76877 C57BL/6J ±  kb
transcript OTTMUST00000002309 VEGA | MGI Sequence Detail 3856 Not Applicable  
polypeptide OTTMUSP00000001137 VEGA | MGI Sequence Detail 767 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    248 from dbSNP Build 142
  • RFLP
    6
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016542 DNA topoisomerase 1
  • EC
    5.99.1.2
  • InterPro Domains
    IPR011010 DNA breaking-rejoining enzyme, catalytic core
    IPR001631 DNA topoisomerase I
    IPR018521 DNA topoisomerase I, active site
    IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain
    IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
    IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type
    IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
    IPR013030 DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type
    IPR013034 DNA topoisomerase I, domain 1
    IPR013499 DNA topoisomerase I, eukaryotic-type
    IPR025834 Topoisomerase I C-terminal domain
Molecular
Reagents
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  • All nucleic 30
    Genomic 5
    cDNA 25

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15165, MGD-MRK-15167, MGI:2138977
References
more
  • Summaries
    All 62
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:14878 Rettenberger G, et al., Localization of the type I DNA topoisomerase gene in man and mouse. Cytogenet Cell Genet. 1991;58:2032 (Abstr.)
  • Latest
    J:216729 Mabb AM, et al., Topoisomerase 1 inhibition reversibly impairs synaptic function. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17290-5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory