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Top1 Gene Detail
Summary
  • Symbol
    Top1
  • Name
    topoisomerase (DNA) I
  • Synonyms
    D130064I21Rik, Top-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98788
    NCBI Gene: 21969
  • Gene Overview
    MyGene.info: TOP1
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:160645897-160722764 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 80.96 cM, cytoband H2-3
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98788
 protein coding gene Chr2:160645888-160722764 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026805
 protein coding gene Chr2:165840663-165922930 (+)
A/J MGP_AJ_G0026771
 protein coding gene Chr2:159172142-159253631 (+)
AKR/J MGP_AKRJ_G0026742
 protein coding gene Chr2:163885983-163966175 (+)
BALB/cJ MGP_BALBcJ_G0026780
 protein coding gene Chr2:159489327-159568864 (+)
C3H/HeJ MGP_C3HHeJ_G0026522
 protein coding gene Chr2:164210307-164291013 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027229
 protein coding gene Chr2:170745406-170835650 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024599
 protein coding gene Chr2:152546438-152626949 (+)
CAST/EiJ MGP_CASTEiJ_G0025984
 protein coding gene Chr2:164579881-164665065 (+)
CBA/J MGP_CBAJ_G0026499
 protein coding gene Chr2:176875384-176962670 (+)
DBA/2J MGP_DBA2J_G0026637
 protein coding gene Chr2:158355641-158433762 (+)
FVB/NJ MGP_FVBNJ_G0026604
 protein coding gene Chr2:156759092-156836567 (+)
LP/J MGP_LPJ_G0026740
 protein coding gene Chr2:165942867-166029532 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026625
 protein coding gene Chr2:180592125-180683972 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027285
 protein coding gene Chr2:163718929-163800321 (+)
PWK/PhJ MGP_PWKPhJ_G0025718
 protein coding gene Chr2:157905802-157985066 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025521
 protein coding gene Chr2:162604442-162691367 (+)
WSB/EiJ MGP_WSBEiJ_G0026054
 protein coding gene Chr2:164617342-164697778 (+)



Homology
more
  • Human Ortholog
    TOP1, DNA topoisomerase I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP1, DNA topoisomerase I
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TOPI
  • Links
    NCBI Gene ID: 7150
    neXtProt AC: NX_P11387
    UniProt: P11387

  • Chr Location
    20q12; chr20:41028822-41124487 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A homozygous mutation resulted in early embryonic lethality at the 4 to 16 cell stage of development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    643
  • Tissues
    10
  • cDNA Data
    25
  • Literature Summary
    6
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21969 NCBI Gene Model | MGI Sequence Detail 76868 C57BL/6J ±  kb
transcript NM_009408 RefSeq | MGI Sequence Detail 3859 C57BL/6  
polypeptide Q04750 UniProt | EBI | MGI Sequence Detail 767 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016542 type 1B DNA topoisomerase 1
    (term hierarchy)
  • EC
    5.6.2.1
  • InterPro Domains
    IPR011010 DNA breaking-rejoining enzyme, catalytic core
    IPR001631 DNA topoisomerase I
    IPR018521 DNA topoisomerase I, active site
    IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain
    IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
    IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type
    IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
    IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
    IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1
    IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2
    IPR013499 DNA topoisomerase I, eukaryotic-type
    IPR025834 Topoisomerase I C-terminal domain
Molecular
Reagents
less
  • All nucleic 31
    Genomic 5
    cDNA 26

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15165, MGD-MRK-15167, MGI:2138977
References
more
  • Summaries
    All 71
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 13
  • Earliest
    J:14878 Rettenberger G, et al., Localization of the type I DNA topoisomerase gene in man and mouse. Cytogenet Cell Genet. 1991;58:2032 (Abstr.)
  • Latest
    J:292445 Fragola G, et al., Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration. Nat Commun. 2020 Apr 23;11(1):1962
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/12/2021
MGI 6.16 		The Jackson Laboratory