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Tnp2
Gene Detail
Symbol

Name
ID
Tnp2
transition protein 2
MGI:98785
Synonyms
Tp-2, TP2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
5.83 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:10787936-10788655 bp, - strand
From Ensembl annotation of GRCm38

  720 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137259  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: TNP2
Protein SuperFamily: spermatid transition protein 2
Gene Tree: Tnp2

Human
homologs
TNP2, transition protein 2 (during histone to protamine replacement)
Orthology source: HGNC

IDs:
NCBI Gene ID: 7142
neXtProt AC: NX_Q05952

Human Synonyms: TP2

Human Chr (Location): 16p13.13; chr16:11267857-11269303 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Males homozygous for targeted null mutations produce small litters and exhibit incomplete chromatin condensation, sperm head abnormalities, and reduced sperm motility. Severity of the phenotype is influenced by genetic background.
 
Interactions
Tnp2 interacts with 34 markers (Mir1b, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process acrosome reaction, binding of sperm to zona pellucida, ...
Component cell, chromosome, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (12)    Tissues (2)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
Northern blot 3
RT-PCR 3
cDNA source data(93)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) Genomic(4) cDNA(94) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000043050 (Evidence)
Entrez Gene 21959 (Evidence)
UniGene 206798
DFCI TC1576575
DoTS DT.91344944
NIA Mouse Gene Index U036783
Consensus CDS Project CCDS27953.1
International Mouse Phenotyping Consortium Status Tnp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043050 Ensembl Gene Model | MGI Sequence Detail 720 C57BL/6J ±  kb
transcript ENSMUST00000051297 Ensembl | MGI Sequence Detail 549 Not Applicable 
polypeptide ENSMUSP00000053078 Ensembl | MGI Sequence Detail 117 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000678 Nuclear transition protein 2
Protein Ontology PR:000016512 nuclear transition protein 2
References
(Earliest) J:8975 Kleene KC, et al., Characterization of a cDNA clone encoding a basic protein, TP2, involved in chromatin condensation during spermiogenesis in the mouse. J Biol Chem. 1987 Dec 25;262(36):17272-7
(Latest) J:203322 Hussain S, et al., The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol Cell Biol. 2013 Apr;33(8):1561-70
All references(49)
Other
accession IDs
MGD-MRK-15160, MGD-MRK-15174

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory