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Tnp2 Gene Detail
Summary
  • Symbol
    Tnp2
  • Name
    transition protein 2
  • Synonyms
    Tp-2, TP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98785
    NCBI Gene: 21959
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10605799-10606519 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 5.83 cM, cytoband B1-B3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98785
 protein coding gene Chr16:10605799-10606524 (-)
129S1/SvImJ ENSMUSG00200011194
 protein coding gene Chr16:7610358-7611082 (-)
A/J ENSMUSG00195010251
 protein coding gene Chr16:7149408-7150132 (-)
AKR/J ENSMUSG00220017007
 protein coding gene Chr16:7438209-7438935 (-)
BALB/cJ ENSMUSG00180008529
 protein coding gene Chr16:7388604-7389328 (-)
C3H/HeJ ENSMUSG00175025790
 protein coding gene Chr16:7577669-7578393 (-)
C57BL/6NJ ENSMUSG00215012364
 protein coding gene Chr16:7255685-7256409 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020448
 protein coding gene Chr16:7343616-7344339 (-)
CAST/EiJ ENSTCUG00005028663
 protein coding gene Chr16:7498676-7499400 (-)
CBA/J ENSMUSG00210011424
 protein coding gene Chr16:7594839-7595563 (-)
DBA/2J ENSMUSG00185010047
 protein coding gene Chr16:7540147-7540871 (-)
FVB/NJ ENSMUSG00205012024
 protein coding gene Chr16:7458652-7459376 (-)
JF1/MsJ ENSUMUG00000021707
 protein coding gene Chr16:7652592-7653316 (-)
LP/J ENSMUSG00230041761
 protein coding gene Chr16:10106140-10106864 (-)
NOD/ShiLtJ ENSMUSG00190025317
 protein coding gene Chr16:7640841-7641565 (-)
NZO/HlLtJ ENSMUSG00225030726
 protein coding gene Chr16:13325170-13325894 (-)
PWK/PhJ ENSLUMG00010017259
 protein coding gene Chr16:7501924-7502648 (-)
SPRET/EiJ ENSMSPG00010016052
 protein coding gene Chr16:7473837-7474561 (-)
WSB/EiJ ENSIUOG00005016049
 protein coding gene Chr16:7604428-7605143 (-)



Homology
more
  • Human Ortholog
    TNP2, transition protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNP2, transition protein 2
  • Synonyms
    TP2
  • Links
    NCBI Gene ID: 7142
    UniProt: Q05952

  • Chr Location
    16p13.13; chr16:11267748-11269533 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for targeted null mutations produce small litters and exhibit incomplete chromatin condensation, sperm head abnormalities, and reduced sperm motility. Severity of the phenotype is influenced by genetic background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    2
  • cDNA Data
    94
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21959 NCBI Gene Model | MGI Sequence Detail 721 C57BL/6J ±  kb
    transcript NM_013694 RefSeq | MGI Sequence Detail 724 Not Specified  
    polypeptide P11378 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      Genomic 4
      cDNA 95
      Primer pair 2
      Other 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15160, MGD-MRK-15174
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 13
      Gene Ontology 15
      Phenotypes 9
    • Earliest
      J:8975 Kleene KC, et al., Characterization of a cDNA clone encoding a basic protein, TP2, involved in chromatin condensation during spermiogenesis in the mouse. J Biol Chem. 1987 Dec 25;262(36):17272-7
    • Latest
      J:374041 Verma A, et al., Parental noncoding RNA expression dynamics across sperm, oocyte, and zygote. NAR Genom Bioinform. 2025 Dec;7(4):lqaf136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory