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Tmod1
Gene Detail
Symbol

Name
ID
Tmod1
tropomodulin 1
MGI:98775
Synonyms
erythrocyte tropomodulin, E-Tmod
Feature Type
protein coding gene
Genetic Map
Chromosome 4
24.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:46038935-46116032 bp, + strand
From VEGA annotation of GRCm38

  77098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMOD1
Protein SuperFamily: tropomodulin
Gene Tree: Tmod1

Human
homologs
TMOD1, tropomodulin 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7111
neXtProt AC: NX_P28289

Human Synonyms: D9S57E, ETMOD, TMOD

Human Chr (Location): 9q22.3; chr9:97501180-97601743 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from CvDC )
 
Homozygous inactivation of this locus results in aborted heart development and consequent embryonic lethality.
 
Phenotype Images(2)
Interactions
Tmod1 interacts with 241 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process actin filament organization, adult locomotory behavior, ...
Component COP9 signalosome, cortical cytoskeleton, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (87)    Tissues (33)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 71
Western blot 10
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TMOD1 ; Xenbase tmod1 ; ZFIN tmod1    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000006835 (Evidence)
Ensembl Gene Model ENSMUSG00000028328 (Evidence)
Entrez Gene 21916 (Evidence)
NIA Mouse Gene Index U004281
Consensus CDS Project CCDS18143.1
International Mouse Phenotyping Consortium Status Tmod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006835 VEGA Gene Model | MGI Sequence Detail 77098 C57BL/6J ±  kb
transcript OTTMUST00000015799 VEGA | MGI Sequence Detail 3158 Not Applicable 
polypeptide OTTMUSP00000007260 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(701 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004934 Tropomodulin
Protein Ontology PR:000016444 tropomodulin-1
References
(Earliest) J:22833 Pilz A, et al., Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse. Genomics. 1995 Jan 1;25(1):139-49
(Latest) J:221197 Yao W, et al., Cell type-restricted expression of erythrocyte tropomodulin Isoform41 in exon 1 knockout/LacZ knock-in heterozygous mice. Gene Expr Patterns. 2015 Jan;17(1):45-55
All references(48)
Other
accession IDs
MGD-MRK-15145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory