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Tmod1
Gene Detail
 Symbol
Name
ID
Tmod1
tropomodulin 1
MGI:98775
Synonyms erythrocyte tropomodulin, E-Tmod
Feature Type protein coding gene
Genetic Map
Chromosome 4
24.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:46038935-46116032 bp, + strand
From VEGA annotation of GRCm38

  77098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tropomodulin
Gene Tree: Tmod1

Human
homologs
Human Homolog TMOD1, tropomodulin 1
NCBI Gene ID 7111
neXtProt AC  NX_P28289
Human Synonyms  D9S57E, ETMOD, TMOD
Human Chr (Location)  9q22.3; chr9:97501180-97601743 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous inactivation of this locus results in aborted heart development and consequent embryonic lethality.
 
Phenotype Images(2)
Interactions
Tmod1 interacts with 242 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process adult locomotory behavior, muscle contraction, ...
Component COP9 signalosome, cortical cytoskeleton, ...
Function actin binding, tropomyosin binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (87)    Tissues (33)    Images (31)
Theiler Stages: 12, 13, 14, 15, 19, 20, 22, 23, 24
Assay TypeResults
Immunohistochemistry 6
RNA in situ 71
Western blot 10
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006835 (Evidence)
Ensembl Gene ModelENSMUSG00000028328 (Evidence)
Entrez Gene21916 (Evidence)
NIA Mouse Gene IndexU004281
Consensus CDS ProjectCCDS18143.1
International Mouse Knockout Project StatusTmod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006835 VEGA Gene Model | MGI Sequence Detail 77098 C57BL/6J ±  kb
transcript OTTMUST00000015799 VEGA | MGI Sequence Detail 3158 Not Applicable 
polypeptide OTTMUSP00000007260 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(701 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004934 Tropomodulin
Protein Ontology PR:000016444 tropomodulin-1
References (Earliest) J:22833 Pilz A, et al., Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse. Genomics. 1995 Jan 1;25(1):139-49
(Latest) J:211921 McKeown CR, et al., Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo. Dev Dyn. 2014 Jun;243(6):800-17
All references(47)
Other
accession IDs
MGD-MRK-15145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory