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Tk1
Gene Detail
Symbol

Name
ID
Tk1
thymidine kinase 1
MGI:98763
Synonyms
D530002A18Rik, Tk-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
82.96 cM, cytoband E1-E2
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr11:117815526-117826092 bp, - strand
From VEGA annotation of GRCm38

  10567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37749  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TK1
Protein SuperFamily: thymidine kinase
Gene Tree: Tk1

Human
homologs
TK1, thymidine kinase 1, soluble
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7083
neXtProt AC: NX_P04183

Human Synonyms: TK2

Human Chr (Location): 17q23.2-q25.3; chr17:78174079-78187204 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show partial postnatal lethality, poor fertility, hemosiderosis, lymphocyte and spleen anomalies, altered sublingual gland secretion, inflammation of the arteries, lung, liver and thyroid, abnormal spermatogenesis and glomerulosclerosis leading to kidney failure and premature death.
 
Interactions
Tk1 interacts with 35 markers (Mir7b, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process deoxyribonucleoside monophosphate biosynthetic process, DNA biosynthetic process, ...
Component cytoplasm
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (110)    Tissues (105)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
Northern blot 6
RT-PCR 2
cDNA source data(98)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tk1 ; ZFIN tk1    NEW 
Molecular
reagents
All nucleic(110) Genomic(5) cDNA(98) Primer pair(1) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000003734 (Evidence)
Ensembl Gene Model ENSMUSG00000025574 (Evidence)
Entrez Gene 21877 (Evidence)
UniGene 2661
DFCI TC1574687, TC1612612, TC1735537, TC1739609
NIA Mouse Gene Index U033669, U069182
EC 2.7.1.21
Consensus CDS Project CCDS25692.1
International Mouse Phenotyping Consortium Status Tk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003734 VEGA Gene Model | MGI Sequence Detail 10567 C57BL/6J ±  kb
transcript OTTMUST00000008130 VEGA | MGI Sequence Detail 1440 Not Applicable 
polypeptide OTTMUSP00000003959 VEGA | MGI Sequence Detail 233 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001267 Thymidine kinase
InterPro IPR020633 Thymidine kinase, conserved site
Protein Ontology PR:000016367 thymidine kinase, cytosolic
References
(Earliest) J:5857 McBreen P, et al., Synteny of the genes for thymidine kinase and galactokinase in the mouse and their assignment to mouse chromosome 11. Cytogenet Cell Genet. 1977;19(1):7-13
(Latest) J:190862 Austin WR, et al., Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012 Nov 19;209(12):2215-28
All references(74)
Other
accession IDs
MGD-MRK-15121, MGD-MRK-15124, MGI:2444019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory