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Tjp1
Gene Detail
Symbol

Name
ID
Tjp1
tight junction protein 1
MGI:98759
Synonyms
ZO1, ZO-1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
35.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:65296165-65371239 bp, - strand
From VEGA annotation of GRCm38

  75075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TJP1
Gene Tree: Tjp1

Human
homologs
TJP1, tight junction protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7082
neXtProt AC: NX_Q07157

Human Synonyms: ZO-1

Human Chr (Location): 15q13; chr15:29699367-29968799 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit no overt phenotype.
 
Interactions
Tjp1 interacts with 349 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process blastocyst formation, establishment of endothelial intestinal barrier, ...
Component adherens junction, apical junction complex, ...
Function calmodulin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (241 records)
Data Summary: Results (449)    Tissues (162)    Images (179)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 155
RNA in situ 214
Western blot 11
RT-PCR 69
cDNA source data(150)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TJP1 ; Xenbase tjp1 ; ZFIN tjp1a, tjp1b    NEW 
Molecular
reagents
All nucleic(158) cDNA(151) Primer pair(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016466 (Evidence)
Ensembl Gene Model ENSMUSG00000030516 (Evidence)
Entrez Gene 21872 (Evidence)
UniGene 4342
DFCI TC1574883, TC1603444
DoTS DT.101384110, DT.111014974, DT.493947
NIA Mouse Gene Index U028678
PDB 2RRM
Consensus CDS Project CCDS21338.1, CCDS52266.1
International Mouse Phenotyping Consortium Status Tjp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016466 VEGA Gene Model | MGI Sequence Detail 75075 C57BL/6J ±  kb
transcript OTTMUST00000039673 VEGA | MGI Sequence Detail 7049 Not Applicable 
polypeptide OTTMUSP00000017707 VEGA | MGI Sequence Detail 1745 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(26) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
InterPro IPR005417 Zona occludens protein
InterPro IPR005418 Zona occludens protein ZO-1
InterPro IPR000906 ZU5
Protein Ontology PR:000016364 tight junction protein ZO-1
References
(Earliest) J:115213 Fleming TP, et al., Epithelial differentiation and intercellular junction formation in the mouse early embryo. Dev Suppl. 1992;Suppl:105-12
(Latest) J:220469 Grego-Bessa J, et al., Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
All references(331)
Other
accession IDs
MGD-MRK-15119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory