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Tjp1
Gene Detail
 Symbol
Name
ID
Tjp1
tight junction protein 1
MGI:98759
Synonyms ZO1, ZO-1
Feature Type protein coding gene
Genetic Map
Chromosome 7
35.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:65296165-65371239 bp, - strand
From VEGA annotation of GRCm38

  75075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2445  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tjp1

Human
homologs
Human Homolog TJP1, tight junction protein 1
NCBI Gene ID 7082
neXtProt AC  NX_Q07157
Human Synonyms  ZO-1
Human Chr (Location)  15q13; chr15:29700134-29968835 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit no overt phenotype.
 
Interactions
Tjp1 interacts with 349 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process blastocyst formation, sensory perception of sound
Component adherens junction, apical junction complex, ...
Function calmodulin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (215 records)
Data Summary: Results (433)    Tissues (151)    Images (167)
Theiler Stages: 2, 3, 4, 5, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 139
RNA in situ 214
Western blot 11
RT-PCR 69
cDNA source data(150)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(158) cDNA(151) Primer pair(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016466 (Evidence)
Ensembl Gene ModelENSMUSG00000030516 (Evidence)
Entrez Gene21872 (Evidence)
UniGene4342
DFCITC1574883, TC1603444
DoTSDT.101384110, DT.111014974, DT.493947
NIA Mouse Gene IndexU028678
PDB2RRM
Consensus CDS ProjectCCDS21338.1, CCDS52266.1
International Mouse Knockout Project StatusTjp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016466 VEGA Gene Model | MGI Sequence Detail 75075 C57BL/6J ±  kb
transcript OTTMUST00000039673 VEGA | MGI Sequence Detail 7049 Not Applicable 
polypeptide OTTMUSP00000017707 VEGA | MGI Sequence Detail 1745 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(22) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
InterPro IPR005417 Zona occludens protein
InterPro IPR005418 Zona occludens protein ZO-1
InterPro IPR000906 ZU5
Protein Ontology PR:000016364 tight junction protein ZO-1
References (Earliest) J:115213 Fleming TP, et al., Epithelial differentiation and intercellular junction formation in the mouse early embryo. Dev Suppl. 1992;Suppl:105-12
(Latest) J:208850 Hatakeyama J, et al., Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. 2014 Apr;141(8):1671-82
All references(302)
Other
accession IDs
MGD-MRK-15119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory