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Timp2 Gene Detail
Summary
  • Symbol
    Timp2
  • Name
    tissue inhibitor of metalloproteinase 2
  • Synonyms
    D11Bwg1104e, Timp-2, TIMP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98753
    NCBI Gene: 21858
  • Gene Overview
    MyGene.info: TIMP2
Location & Maps
more
  • Sequence Map
    Chr11:118301069-118355740 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      54672 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.09 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TIMP2, TIMP metallopeptidase inhibitor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TIMP2, TIMP metallopeptidase inhibitor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSC-21K, DDC8
  • Links
    NCBI Gene ID: 7077
    neXtProt AC: NX_P16035

  • Chr Location
    17q25; chr17:78852977-78925390 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    4
  • Targeted
    4
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit impaired activation of pro-matrix metalloproteinase-2, but appear phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003883 VEGA Gene Model | MGI Sequence Detail 54672 C57BL/6J ±  kb
transcript OTTMUST00000008565 VEGA | MGI Sequence Detail 3709 Not Applicable  
polypeptide OTTMUSP00000004170 VEGA | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    146 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000016353 metalloproteinase inhibitor 2
  • InterPro Domains
    IPR015613 Metalloproteinase inhibitor 2
    IPR001134 Netrin domain
    IPR001820 Protease inhibitor I35 (TIMP)
    IPR027465 Proteinase inhibitor I35b (TIMP), C-terminal
    IPR030490 Tissue inhibitor of metalloproteinase, conserved site
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Molecular
Reagents
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  • All nucleic 322
    cDNA 309
    Primer pair 12
    Other 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-15111, MGD-MRK-15113, MGD-MRK-34056, MGI:106364
References
more
  • Summaries
    All 114
    Developmental Gene Expression 41
    Gene Ontology 10
    Phenotypes 26
  • Earliest
    J:1243 Shimizu S, et al., Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2. Gene. 1992 May 15;114(2):291-2
  • Latest
    J:229619 Jackson HW, et al., Timp3 deficient mice show resistance to developing breast cancer. PLoS One. 2015;10(3):e0120107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory