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Timp2
Gene Detail
Symbol

Name
ID
Timp2
tissue inhibitor of metalloproteinase 2
MGI:98753
Synonyms
D11Bwg1104e, Timp-2, TIMP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
83.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:118301069-118355740 bp, - strand
From VEGA annotation of GRCm38

  54672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2444  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: metalloproteinase inhibitor
Gene Tree: Timp2

Human
homologs
Human Homolog TIMP2, TIMP metallopeptidase inhibitor 2
NCBI Gene ID 7077
neXtProt AC  NX_P16035
Human Synonyms  CSC-21K, DDC8
Human Chr (Location)  17q25; chr17:78852977-78925390 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit impaired activation of pro-matrix metalloproteinase-2, but appear phenotypically normal.
 
Interactions
Timp2 interacts with 271 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular response to organic substance, negative regulation of cell proliferation, ...
Component basement membrane, cell surface, ...
Function enzyme activator activity, enzyme inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (140)    Tissues (63)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
Northern blot 25
Western blot 36
RT-PCR 60
cDNA source data(307)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(322) cDNA(309) Primer pair(12) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000003883 (Evidence)
Ensembl Gene ModelENSMUSG00000017466 (Evidence)
Entrez Gene21858 (Evidence)
UniGene206505
DFCITC1572992, TC1638646
DoTSDT.101245698, DT.101324078, DT.97369313
NIA Mouse Gene IndexU033681
Consensus CDS ProjectCCDS25699.1
International Mouse Knockout Project StatusTimp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003883 VEGA Gene Model | MGI Sequence Detail 54672 C57BL/6J ±  kb
transcript OTTMUST00000008565 VEGA | MGI Sequence Detail 3709 Not Applicable 
polypeptide OTTMUSP00000004170 VEGA | MGI Sequence Detail 220 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(151 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001134 Netrin domain
InterPro IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
InterPro IPR027465 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain
InterPro IPR015613 Tissue inhibitor of metalloprotease 2
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000016353 metalloproteinase inhibitor 2
References
(Earliest) J:1243 Shimizu S, et al., Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2. Gene. 1992 May 15;114(2):291-2
(Latest) J:211441 Basu R, et al., TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension. Cardiovasc Res. 2013 Jun 1;98(3):360-71
All references(109)
Other
accession IDs
MGD-MRK-15111, MGD-MRK-15113, MGD-MRK-34056, MGI:106364

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory