Thbs3
Gene Detail

Symbol Name ID

Thbs3 thrombospondin 3 MGI:98739

Synonyms

Thbs-3, TSP3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.01 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr3:89215180-89226837 bp, + strand From VEGA annotation of GRCm38   11658 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5159  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: thrombospondin 3
Gene Tree: Thbs3

Human homologs

Human Homolog		THBS3, thrombospondin 3
NCBI Gene ID		7059
neXtProt AC		NX_P49746
Human Synonyms		TSP3
Human Chr (Location)		1q21; chr1:155165379-155177772 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(3) Gene trapped(16)
 

Homozygous null mice at a young age are heavier and exhibit femurs with increased periosteal and endocortical diameters, greater moments of inertia and increased bending strength and failure loads, with these defects no longer detected in older mice. Femoral heads show accelerated bone ossification.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	bone trabecula formation, cell adhesion, ...
Component	extracellular region, perinuclear region of cytoplasm
Function	calcium ion binding, heparin binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (73)    Tissues (26)    Images (25)
Theiler Stages: 17, 18, 23

Assay Type	Results
RNA in situ	73

cDNA source data(44)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(15) cDNA(44) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000030357 (Evidence)
Ensembl Gene Model	ENSMUSG00000028047 (Evidence)
Entrez Gene	21827 (Evidence)
UniGene	2114
DFCI	TC1577900, TC1601908
DoTS	DT.531002
NIA Mouse Gene Index	U003459
Consensus CDS Project	CCDS17495.1
International Mouse Knockout Project Status	Thbs3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030357	VEGA Gene Model | MGI Sequence Detail	11658	C57BL/6J
transcript	OTTMUST00000075214	VEGA | MGI Sequence Detail	3190	Not Applicable
polypeptide	OTTMUSP00000039372	VEGA | MGI Sequence Detail	956	Not Applicable

All sequences(59) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR024665	Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
InterPro	IPR008859	Thrombospondin, C-terminal
InterPro	IPR003367	Thrombospondin, type 3-like repeat
InterPro	IPR017897	Thrombospondin, type 3 repeat
Protein Ontology	PR:000000131	thrombospondin-3

References

(Earliest) J:8863 Chou HS, et al., Germline organization of the murine T cell receptor beta-chain genes. Science. 1987 Oct 23;238(4826):545-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(46)

Other accession IDs

MGD-MRK-15085, MGD-MRK-15088