Thbs3 MGI Mouse Gene Detail - MGI:98739

Symbol

Thbs3
Name

thrombospondin 3
Synonyms

Thbs-3, TSP3

Feature Type

protein coding gene
IDs

MGI:98739
NCBI Gene: 21827
Gene Overview

MyGene.info: THBS3
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:89215180-89226837 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.01 cM, cytoband E3-F1
Mapping Data

8 experiments

SNPs within 2kb

50 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98739	protein coding gene	Chr3:89215180-89226841 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027423	protein coding gene	Chr3:89415649-89428066 (+)
A/J	MGP_AJ_G0027387	protein coding gene	Chr3:86455027-86472009 (+)
AKR/J	MGP_AKRJ_G0027351	protein coding gene	Chr3:88550956-88562482 (+)
BALB/cJ	MGP_BALBcJ_G0027396	protein coding gene	Chr3:86424096-86435689 (+)
C3H/HeJ	MGP_C3HHeJ_G0027138	protein coding gene	Chr3:88749820-88763080 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027842	protein coding gene	Chr3:92800218-92813045 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025194	protein coding gene	Chr3:81940027-81951855 (+)
CAST/EiJ	MGP_CASTEiJ_G0026584	protein coding gene	Chr3:89100605-89113576 (+)
CBA/J	MGP_CBAJ_G0027112	protein coding gene	Chr3:95981768-95993301 (+)
DBA/2J	MGP_DBA2J_G0027250	protein coding gene	Chr3:85838801-85850379 (+)
FVB/NJ	MGP_FVBNJ_G0027218	protein coding gene	Chr3:84177853-84191302 (+)
LP/J	MGP_LPJ_G0027359	protein coding gene	Chr3:90496568-90508964 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027238	protein coding gene	Chr3:102201075-102213724 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027901	protein coding gene	Chr3:88301053-88313838 (+)
PWK/PhJ	MGP_PWKPhJ_G0026318	protein coding gene	Chr3:85711498-85722987 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026137	protein coding gene	Chr3:87472035-87483506 (+)
WSB/EiJ	MGP_WSBEiJ_G0026666	protein coding gene	Chr3:88692681-88705190 (+)

Human Ortholog

THBS3, thrombospondin 3

Vertebrate Orthologs

9

Human Ortholog

THBS3, thrombospondin 3
Orthology source: HomoloGene, HGNC
Synonyms

TSP3
Links

HGNC:11787

NCBI Gene ID: 7059

neXtProt AC: NX_P49746

UniProt: P49746
Chr Location

1q22; chr1:155195588-155209180 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5159
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: THBS3
Protein SuperFamily

thrombospondin 3
Gene Tree

Thbs3

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Gene trapped

16
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

2 involving Thbs3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice at a young age are heavier and exhibit femurs with increased periosteal and endocortical diameters, greater moments of inertia and increased bending strength and failure loads, with these defects no longer detected in older mice. Femoral heads show accelerated bone ossification.

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All GO Annotations

11
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

97
cDNA Data

47
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thbs3

ZFIN thbs3a

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Thbs3 interacts with 105 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

52
RefSeq

5
UniProt

4
CCDS

CCDS17495.1
UniGene

2114

Ensembl

ENSMUSG00000028047 (Evidence)
NCBI Gene

21827

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028047	Ensembl Gene Model \| MGI Sequence Detail	11658	C57BL/6J	± kb
transcript	ENSMUST00000029682	Ensembl \| MGI Sequence Detail	3190	Not Applicable
polypeptide	ENSMUSP00000029682	Ensembl \| MGI Sequence Detail	956	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000000131 thrombospondin-3

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR001791 Laminin G domain

IPR028507 Thrombospondin-3

IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain

IPR008859 Thrombospondin, C-terminal

IPR003367 Thrombospondin, type 3-like repeat

IPR017897 Thrombospondin, type 3 repeat

IPR028974 TSP type-3 repeat

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All nucleic 63

Genomic 15

cDNA 47

Other 1

Microarray probesets 2

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MGD-MRK-15085, MGD-MRK-15088

Summaries

All 50

Developmental Gene Expression 9

Diseases 1

Gene Ontology 7

Phenotypes 13
Earliest

J:8863 Chou HS, et al., Germline organization of the murine T cell receptor beta-chain genes. Science. 1987 Oct 23;238(4826):545-8
Latest

J:271593 Schips TG, et al., Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nat Commun. 2019 Jan 8;10(1):76

TSS for Thbs3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30071	Chr3:89215170-89215181 (+)	-4 bp
Tssr30072	Chr3:89215192-89215243 (+)	38 bp
Tssr30073	Chr3:89225072-89225084 (+)	9,898 bp
Tssr30074	Chr3:89226174-89226196 (+)	11,005 bp
Tssr937	Chr3:89226229-89226268 (+)	11,069 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/10/2020 MGI 6.16