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Thbs3 Gene Detail
Summary
  • Symbol
    Thbs3
  • Name
    thrombospondin 3
  • Synonyms
    Thbs-3, TSP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98739
    NCBI Gene: 21827
  • Gene Overview
    MyGene.info: THBS3
Location & Maps
more
  • Sequence Map
    Chr3:89215180-89226837 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      11658 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.01 cM, cytoband E3-F1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    THBS3, thrombospondin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    THBS3, thrombospondin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TSP3
  • Links
    NCBI Gene ID: 7059
    neXtProt AC: NX_P49746
    UniProt: P49746

  • Chr Location
    1q22; chr1:155195588-155209180 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice at a young age are heavier and exhibit femurs with increased periosteal and endocortical diameters, greater moments of inertia and increased bending strength and failure loads, with these defects no longer detected in older mice. Femoral heads show accelerated bone ossification.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    149
  • Tissues
    97
  • cDNA Data
    46
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030357 VEGA Gene Model | MGI Sequence Detail 11658 C57BL/6J ±  kb
transcript OTTMUST00000075214 VEGA | MGI Sequence Detail 3190 Not Applicable  
polypeptide OTTMUSP00000039372 VEGA | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    50 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    Genomic 15
    cDNA 46
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-15085, MGD-MRK-15088
References
more
  • Summaries
    All 45
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:8863 Chou HS, et al., Germline organization of the murine T cell receptor beta-chain genes. Science. 1987 Oct 23;238(4826):545-8
  • Latest
    J:227951 Mendus D, et al., Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. Eur J Neurosci. 2014 Apr;39(8):1256-67
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/13/2017
MGI 6.10 		The Jackson Laboratory