Thbs3 MGI Mouse Gene Detail - MGI:98739

Thbs3 Gene Detail

Symbol

Thbs3
Name

thrombospondin 3
Synonyms

Thbs-3, TSP3

Feature Type

protein coding gene
IDs

MGI:98739
NCBI Gene: 21827
Gene Overview

MyGene.info: THBS3

Sequence Map

Chr3:89215180-89226837 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

11658 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.01 cM, cytoband E3-F1
Mapping Data

8 experiments

Human Ortholog

THBS3, thrombospondin 3

Vertebrate Orthologs

9

Human Ortholog

THBS3, thrombospondin 3
Orthology source: HomoloGene, HGNC
Synonyms

TSP3
Links

HGNC:11787

NCBI Gene ID: 7059

neXtProt AC: NX_P49746

UniProt: P49746
Chr Location

1q22; chr1:155195588-155209180 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5159
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: THBS3
Protein SuperFamily

thrombospondin 3
Gene Tree

Thbs3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Gene trapped

16
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Thbs3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Homozygous null mice at a young age are heavier and exhibit femurs with increased periosteal and endocortical diameters, greater moments of inertia and increased bending strength and failure loads, with these defects no longer detected in older mice. Femoral heads show accelerated bone ossification.

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All GO Annotations

10
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

149
Tissues

97
cDNA Data

46
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thbs3

ZFIN thbs3a

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Thbs3 interacts with 105 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

56
RefSeq

11
UniProt

4
CCDS

CCDS17495.1
UniGene

2114

			Length	Strain/Species	Flank
genomic	OTTMUSG00000030357	VEGA Gene Model \| MGI Sequence Detail	11658	C57BL/6J	± kb
transcript	OTTMUST00000075214	VEGA \| MGI Sequence Detail	3190	Not Applicable
polypeptide	OTTMUSP00000039372	VEGA \| MGI Sequence Detail	956	Not Applicable

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SNPs within 2kb

50 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000000131 thrombospondin-3

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR001791 Laminin G domain

IPR028507 Thrombospondin-3

IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain

IPR008859 Thrombospondin, C-terminal

IPR003367 Thrombospondin, type 3-like repeat

IPR017897 Thrombospondin, type 3 repeat

IPR028974 TSP type-3 repeat

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All nucleic 62

Genomic 15

cDNA 46

Other 1

Microarray probesets 2

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MGD-MRK-15085, MGD-MRK-15088

Summaries

All 45

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 11
Earliest

J:8863 Chou HS, et al., Germline organization of the murine T cell receptor beta-chain genes. Science. 1987 Oct 23;238(4826):545-8
Latest

J:227951 Mendus D, et al., Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. Eur J Neurosci. 2014 Apr;39(8):1256-67

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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