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Thbs3
Gene Detail
Symbol

Name
ID
Thbs3
thrombospondin 3
MGI:98739
Synonyms
Thbs-3, TSP3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.01 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr3:89215180-89226837 bp, + strand
From VEGA annotation of GRCm38

  11658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: thrombospondin 3
Gene Tree: Thbs3

Human
homologs
Human Homolog THBS3, thrombospondin 3
NCBI Gene ID 7059
neXtProt AC  NX_P49746
Human Synonyms  TSP3
Human Chr (Location)  1q21; chr1:155195588-155208906 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice at a young age are heavier and exhibit femurs with increased periosteal and endocortical diameters, greater moments of inertia and increased bending strength and failure loads, with these defects no longer detected in older mice. Femoral heads show accelerated bone ossification.
 
Interactions
Thbs3 interacts with 105 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process bone trabecula formation, cell adhesion, ...
Component extracellular region, perinuclear region of cytoplasm
Function calcium ion binding, heparin binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (74)    Tissues (27)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
cDNA source data(44)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) Genomic(15) cDNA(44) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000030357 (Evidence)
Ensembl Gene ModelENSMUSG00000028047 (Evidence)
Entrez Gene21827 (Evidence)
UniGene2114
DFCITC1577900, TC1601908
DoTSDT.531002
NIA Mouse Gene IndexU003459
Consensus CDS ProjectCCDS17495.1
International Mouse Knockout Project StatusThbs3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030357 VEGA Gene Model | MGI Sequence Detail 11658 C57BL/6J ±  kb
transcript OTTMUST00000075214 VEGA | MGI Sequence Detail 3190 Not Applicable 
polypeptide OTTMUSP00000039372 VEGA | MGI Sequence Detail 956 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001791 Laminin G domain
InterPro IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
InterPro IPR008859 Thrombospondin, C-terminal
InterPro IPR003367 Thrombospondin, type 3-like repeat
InterPro IPR017897 Thrombospondin, type 3 repeat
Protein Ontology PR:000000131 thrombospondin-3
References
(Earliest) J:8863 Chou HS, et al., Germline organization of the murine T cell receptor beta-chain genes. Science. 1987 Oct 23;238(4826):545-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(46)
Other
accession IDs
MGD-MRK-15085, MGD-MRK-15088

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory