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Th
Gene Detail
 Symbol
Name
ID
Th
tyrosine hydroxylase
MGI:98735
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr7:142892752-142931128 bp, - strand
From VEGA annotation of GRCm38

  38377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:307  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine 3-monooxygenase
Gene Tree: Th

Human
homologs
Human Homolog TH, tyrosine hydroxylase
NCBI Gene ID 7054
neXtProt AC  NX_P07101
Human Synonyms  DYT14, DYT5b, TYH
Human Chr (Location)  11p15.5; chr11:2163929-2171805 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TH
Alleles
and
phenotypes
All alleles(18) : Targeted(18)
 
Homozygotes for targeted null mutations are deficient in catecholamines, and usually die around embryonic day 11.5-15.5 due to cardiac failure. Treatment of the pregnant female with dihydroxyphenylalanine prevents prenatal mortality. Mice homozygous for hypomorphic targeted alleles are hypokinetic.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process aromatic amino acid family metabolic process, catecholamine biosynthetic process, ...
Component axon, cytoplasm, ...
Function amino acid binding, dopamine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (465 records)
Data Summary: Results (711)    Tissues (225)    Images (215)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 318
RNA in situ 332
In situ reporter (knock in) 8
Western blot 17
RT-PCR 36
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(47) Genomic(23) cDNA(15) Primer pair(8) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018790 (Evidence)
Ensembl Gene ModelENSMUSG00000000214 (Evidence)
Entrez Gene21823 (Evidence)
UniGene1292
DFCITC1589151
DoTSDT.40185345, DT.91579854
NIA Mouse Gene IndexU029489
EC1.14.16.2
Consensus CDS ProjectCCDS22036.1
International Mouse Knockout Project StatusTh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018790 VEGA Gene Model | MGI Sequence Detail 38377 C57BL/6J ±  kb
transcript OTTMUST00000045229 VEGA | MGI Sequence Detail 1829 Not Applicable 
polypeptide OTTMUSP00000020341 VEGA | MGI Sequence Detail 498 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(6)
Polymorphisms RFLP(4) : SNPs within 2kb(413 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001273 Aromatic amino acid hydroxylase
InterPro IPR019774 Aromatic amino acid hydroxylase, C-terminal
InterPro IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
InterPro IPR005962 Tyrosine 3-monooxygenase
InterPro IPR019773 Tyrosine 3-monooxygenase-like
InterPro IPR021164 Tyrosine hydroxylase, conserved site
Protein Ontology PR:000016301 tyrosine 3-monooxygenase
References (Earliest) J:8890 Vadasz C, et al., Genetic determination of mesencephalic tyrosine hydroxylase activity in the mouse. J Neurogenet. 1987 Aug;4(5):241-52
(Latest) J:206799 Darvas M, et al., Dopamine dependency for acquisition and performance of Pavlovian conditioned response. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2764-9
All references(592)
Other
accession IDs
MGD-MRK-15078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory