Homozygotes for targeted null mutations are deficient in catecholamines, and usually die around embryonic day 11.5-15.5 due to cardiac failure. Treatment of the pregnant female with dihydroxyphenylalanine prevents prenatal mortality. Mice homozygous for hypomorphic targeted alleles are hypokinetic.
|InterPro||IPR001273||Aromatic amino acid hydroxylase|
|InterPro||IPR019774||Aromatic amino acid hydroxylase, C-terminal|
|InterPro||IPR018301||Aromatic amino acid hydroxylase, iron/copper binding site|
|InterPro||IPR021164||Tyrosine hydroxylase, conserved site|
|Protein Ontology||PR:000016301||tyrosine 3-monooxygenase|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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