Th
Gene Detail

Symbol Name ID

Th tyrosine hydroxylase MGI:98735

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr7:142892752-142931128 bp, - strand From VEGA annotation of GRCm38   38377 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:307  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine 3-monooxygenase
Gene Tree: Th

Human homologs

Human Homolog		TH, tyrosine hydroxylase
NCBI Gene ID		7054
neXtProt AC		NX_P07101
Human Synonyms		DYT14, DYT5b, TYH
Human Chr (Location)		11p15.5; chr11:2185159-2193035 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TH

Alleles and phenotypes

All alleles(18) : Targeted(18)
 

Homozygotes for targeted null mutations are deficient in catecholamines, and usually die around embryonic day 11.5-15.5 due to cardiac failure. Treatment of the pregnant female with dihydroxyphenylalanine prevents prenatal mortality. Mice homozygous for hypomorphic targeted alleles are hypokinetic.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (70 annotations)

Process	aromatic amino acid family metabolic process, catecholamine biosynthetic process, ...
Component	axon, cytoplasm, ...
Function	amino acid binding, dopamine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (434 records)
Data Summary: Results (524)    Tissues (205)    Images (147)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	131
RNA in situ	332
In situ reporter (knock in)	8
Western blot	17
RT-PCR	36

cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(23) cDNA(15) Primer pair(8) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018790 (Evidence)
Ensembl Gene Model	ENSMUSG00000000214 (Evidence)
Entrez Gene	21823 (Evidence)
UniGene	1292
DFCI	TC1589151
DoTS	DT.40185345, DT.91579854
NIA Mouse Gene Index	U029489
EC	1.14.16.2
Consensus CDS Project	CCDS22036.1
International Mouse Knockout Project Status	Th

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018790	VEGA Gene Model | MGI Sequence Detail	38377	C57BL/6J
transcript	OTTMUST00000045229	VEGA | MGI Sequence Detail	1829	Not Applicable
polypeptide	OTTMUSP00000020341	VEGA | MGI Sequence Detail	498	Not Applicable

All sequences(44) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(4) : SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001273	Aromatic amino acid hydroxylase
InterPro	IPR019774	Aromatic amino acid hydroxylase, C-terminal
InterPro	IPR018301	Aromatic amino acid hydroxylase, iron/copper binding site
InterPro	IPR005962	Tyrosine 3-monooxygenase
InterPro	IPR019773	Tyrosine 3-monooxygenase-like
InterPro	IPR021164	Tyrosine hydroxylase, conserved site
Protein Ontology	PR:000016301	tyrosine 3-monooxygenase

References

(Earliest) J:8890 Vadasz C, et al., Genetic determination of mesencephalic tyrosine hydroxylase activity in the mouse. J Neurogenet. 1987 Aug;4(5):241-52
(Latest) J:194919 Nam J, et al., Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013 Apr;140(7):1475-85
All references(554)

Other accession IDs

MGD-MRK-15078