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Tgm3
Gene Detail
 Symbol
Name
ID
Tgm3
transglutaminase 3, E polypeptide
MGI:98732
Synonyms TG E
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:130012349-130050399 bp, + strand
From VEGA annotation of GRCm38

  38051 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm3

Human
homologs
Human Homolog TGM3, transglutaminase 3
NCBI Gene ID 7053
neXtProt AC  NX_Q08188
Human Synonyms  TGE
Human Chr (Location)  20q11.2; chr20:2295967-2341079 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(2) Gene trapped(1) Chemically induced(1)
 
Mice homozygous for an ENU or null mutation exhibit rough-looking, curly hair. Null mutants display delayed skin barrier formation, loss of vibrissae, and brittle hairs.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell envelope organization, epidermis development, ...
Component cornified envelope, cytoplasm, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (199)    Tissues (161)    Images (30)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 131
RT-PCR 68
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015499 (Evidence)
Ensembl Gene ModelENSMUSG00000027401 (Evidence)
Entrez Gene21818 (Evidence)
UniGene2961
DFCITC1588373, TC1608524
DoTSDT.486182
NIA Mouse Gene IndexU002464
EC2.3.2.13
Consensus CDS ProjectCCDS38240.1
International Mouse Knockout Project StatusTgm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015499 VEGA Gene Model | MGI Sequence Detail 38051 C57BL/6J ±  kb
transcript OTTMUST00000036811 VEGA | MGI Sequence Detail 4135 Not Applicable 
polypeptide OTTMUSP00000016514 VEGA | MGI Sequence Detail 693 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(305 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016294 protein-glutamine gamma-glutamyltransferase E
References (Earliest) J:12602 Kim IG, et al., The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse. J Biol Chem. 1993 Jun 15;268(17):12682-90
(Latest) J:203964 Bognar P, et al., Reduced inflammatory threshold indicates skin barrier defect in transglutaminase 3 knockout mice. J Invest Dermatol. 2014 Jan;134(1):105-11
All references(40)
Other
accession IDs
MGD-MRK-15074, MGI:2139112

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory