Tgm3
Gene Detail

Symbol Name ID

Tgm3 transglutaminase 3, E polypeptide MGI:98732

Synonyms

TG E

Feature Type

protein coding gene

Genetic Map

Chromosome 2

63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:130012349-130050399 bp, + strand From VEGA annotation of GRCm38   38051 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm3

Human homologs

Human Homolog		TGM3, transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
NCBI Gene ID		7053
neXtProt AC		NX_Q08188
Human Synonyms		TGE
Human Chr (Location)		20q11.2; chr20:2276613-2321725 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Chemically induced(1)
 

Mice homozygous for an ENU or null mutation exhibit rough-looking, curly hair. Null mutants display delayed skin barrier formation, loss of vibrissae, and brittle hairs.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	cell envelope organization, epidermis development, ...
Component	cornified envelope, cytoplasm, ...
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (199)    Tissues (161)    Images (30)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	131
RT-PCR	68

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000015499 (Evidence)
Ensembl Gene Model	ENSMUSG00000027401 (Evidence)
Entrez Gene	21818 (Evidence)
UniGene	2961
DFCI	TC1588373, TC1608524
DoTS	DT.486182
NIA Mouse Gene Index	U002464
EC	2.3.2.13
Consensus CDS Project	CCDS38240.1
International Mouse Knockout Project Status	Tgm3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015499	VEGA Gene Model | MGI Sequence Detail	38051	C57BL/6J
transcript	OTTMUST00000036811	VEGA | MGI Sequence Detail	4135	Not Applicable
polypeptide	OTTMUSP00000016514	VEGA | MGI Sequence Detail	693	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(234 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR023608	Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro	IPR013808	Transglutaminase, conserved site
InterPro	IPR008958	Transglutaminase, C-terminal
InterPro	IPR002931	Transglutaminase-like
InterPro	IPR001102	Transglutaminase, N-terminal
Protein Ontology	PR:000016294	protein-glutamine gamma-glutamyltransferase E

References

(Earliest) J:12602 Kim IG, et al., The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse. J Biol Chem. 1993 Jun 15;268(17):12682-90
(Latest) J:187109 John S, et al., Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier. PLoS One. 2012;7(4):e34252
All references(39)

Other accession IDs

MGD-MRK-15074, MGI:2139112