About   Help   FAQ
Tgm3
Gene Detail
Symbol

Name
ID
Tgm3
transglutaminase 3, E polypeptide
MGI:98732
Synonyms
TG E
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:130012349-130050399 bp, + strand
From VEGA annotation of GRCm38

  38051 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TGM3
Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm3

Human
homologs
TGM3, transglutaminase 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7053
neXtProt AC: NX_Q08188

Human Synonyms: TGE

Human Chr (Location): 20q11.2; chr20:2295967-2341079 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an ENU or null mutation exhibit rough-looking, curly hair. Null mutants display delayed skin barrier formation, loss of vibrissae, and brittle hairs.
 
Phenotype Images(4)
Interactions
Tgm3 interacts with 259 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell envelope organization, epidermis development, ...
Component cornified envelope, cytoplasm, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (199)    Tissues (164)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 131
RT-PCR 68
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015499 (Evidence)
Ensembl Gene Model ENSMUSG00000027401 (Evidence)
Entrez Gene 21818 (Evidence)
UniGene 2961
DFCI TC1588373, TC1608524
DoTS DT.486182
NIA Mouse Gene Index U002464
EC 2.3.2.13
Consensus CDS Project CCDS38240.1
International Mouse Phenotyping Consortium Status Tgm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015499 VEGA Gene Model | MGI Sequence Detail 38051 C57BL/6J ±  kb
transcript OTTMUST00000036811 VEGA | MGI Sequence Detail 4135 Not Applicable 
polypeptide OTTMUSP00000016514 VEGA | MGI Sequence Detail 693 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(305 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016294 protein-glutamine gamma-glutamyltransferase E
References
(Earliest) J:12602 Kim IG, et al., The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse. J Biol Chem. 1993 Jun 15;268(17):12682-90
(Latest) J:203964 Bognar P, et al., Reduced inflammatory threshold indicates skin barrier defect in transglutaminase 3 knockout mice. J Invest Dermatol. 2014 Jan;134(1):105-11
All references(41)
Other
accession IDs
MGD-MRK-15074, MGI:2139112

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory