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Tgm1
Gene Detail
 Symbol
Name
ID
Tgm1
transglutaminase 1, K polypeptide
MGI:98730
Synonyms 2310004J08Rik, K polypeptide, protein-glutamine-gamma-glutamyltransferase, TGase 1, TG K
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:55700009-55713492 bp, - strand
From NCBI annotation of GRCm38

  13484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 7 zebrafish

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm1

Human
homologs
Human Homolog TGM1, transglutaminase 1
NCBI Gene ID 7051
neXtProt AC  NX_P22735
Human Synonyms  ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK
Human Chr (Location)  14q11.2; chr14:24249114-24263210 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TGM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Newborn mice homozygous for a knock-out allele are small and hypoactive and die within hours of birth displaying failure to suckle, progressive dehydration, and epidermal defects including a reddish, tight and wrinkled skin, hyperkeratosis, and impaired skin barrier function.
 
Human Diseases Modeled Using Mouse Tgm1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Tgm1 interacts with 34 markers (Mir22, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process keratinization, keratinocyte differentiation, ...
Component cell-cell adherens junction, extracellular vesicular exosome, ...
Function metal ion binding, protein-glutamine gamma-glutamyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (103)    Tissues (96)    Images (9)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 103
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(31)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000022218 (Evidence)
Entrez Gene21816 (Evidence)
UniGene41964
DFCITC1584232, TC1645336
DoTSDT.101370884, DT.40135751, DT.99847079
NIA Mouse Gene IndexU035586
EC2.3.2.13
Consensus CDS ProjectCCDS36932.1
International Mouse Knockout Project StatusTgm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21816 NCBI Gene Model | MGI Sequence Detail 13484 C57BL/6J ±  kb
transcript NM_001161715 RefSeq | MGI Sequence Detail 2854 C57BL/6 
polypeptide Q9JLF6 UniProt | EBI | MGI Sequence Detail 815 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016292 protein-glutamine gamma-glutamyltransferase K
Graphical View of Protein Domain Structure
References (Earliest) J:13218 Rajagopalan S, et al., Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6179-83
(Latest) J:170194 Itoh M, et al., In situ detection of active transglutaminases for keratinocyte type (TGase 1) and tissue type (TGase 2) using fluorescence-labeled highly reactive substrate peptides. J Histochem Cytochem. 2011 Feb;59(2):180-7
All references(51)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15072, MGI:1916760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory