Tgm1
Gene Detail

Symbol Name ID

Tgm1 transglutaminase 1, K polypeptide MGI:98730

Synonyms

2310004J08Rik, K polypeptide, protein-glutamine-gamma-glutamyltransferase, TGase 1, TG K

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:55700009-55713492 bp, - strand From NCBI annotation of GRCm38   13484 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 6 zebrafish

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm1

Human homologs

Human Homolog		TGM1, transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
NCBI Gene ID		7051
neXtProt AC		NX_P22735
Human Synonyms		ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK
Human Chr (Location)		14q11.2; chr14:24718320-24732416 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TGM1

Alleles and phenotypes

All alleles(18) : Targeted(4) Gene trapped(14)
 

Newborn mice homozygous for a knock-out allele are small and hypoactive and die within hours of birth displaying failure to suckle, progressive dehydration, and epidermal defects including a reddish, tight and wrinkled skin, hyperkeratosis, and impaired skin barrier function.

 
Human Diseases Modeled Using Mouse Tgm1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	keratinization, keratinocyte differentiation, ...
Component	cell-cell adherens junction, intrinsic to membrane, ...
Function	metal ion binding, protein-glutamine gamma-glutamyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (103)    Tissues (96)    Images (9)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	103

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(1) cDNA(31)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000022218 (Evidence)
Entrez Gene	21816 (Evidence)
UniGene	41964
DFCI	TC1584232, TC1645336
DoTS	DT.101370884, DT.40135751, DT.99847079
NIA Mouse Gene Index	U035586
EC	2.3.2.13
Consensus CDS Project	CCDS36932.1
International Mouse Knockout Project Status	Tgm1

Sequences

Length	Strain/Species
genomic	21816	NCBI Gene Model | MGI Sequence Detail	13484	C57BL/6J
transcript	NM_001161715	RefSeq | MGI Sequence Detail	2854	C57BL/6
polypeptide	Q9JLF6	UniProt | EBI | MGI Sequence Detail	815	Not Applicable

All sequences(26) RefSeq(6) UniProt(1)

Polymorphisms

SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR023608	Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro	IPR013808	Transglutaminase, conserved site
InterPro	IPR008958	Transglutaminase, C-terminal
InterPro	IPR002931	Transglutaminase-like
InterPro	IPR001102	Transglutaminase, N-terminal
Protein Ontology	PR:000016292	protein-glutamine gamma-glutamyltransferase K

Graphical View of Protein Domain Structure

References

(Earliest) J:13218 Rajagopalan S, et al., Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6179-83
(Latest) J:170194 Itoh M, et al., In situ detection of active transglutaminases for keratinocyte type (TGase 1) and tissue type (TGase 2) using fluorescence-labeled highly reactive substrate peptides. J Histochem Cytochem. 2011 Feb;59(2):180-7
All references(51)

Other accession IDs

MGD-MRK-15072, MGI:1916760