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Tgm1 Gene Detail
Summary
  • Symbol
    Tgm1
  • Name
    transglutaminase 1, K polypeptide
  • Synonyms
    2310004J08Rik, K polypeptide, protein-glutamine-gamma-glutamyltransferase, TGase1, TGase 1, TG K
  • Feature Type
    protein coding gene
  • IDs
    MGI:98730
    NCBI Gene: 21816
  • Gene Overview
    MyGene.info: TGM1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:55700009-55713921 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13913 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TGM1, transglutaminase 1
  • Vertebrate Orthologs
    15
  • Human Ortholog
    TGM1, transglutaminase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK
  • Links
    NCBI Gene ID: 7051
    neXtProt AC: NX_P22735
    UniProt: P22735

  • Chr Location
    14q12; chr14:24249114-24263210 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 306
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;7 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TGM1
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tgm1 mouse models; 1 with human TGM1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    4 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Newborn mice homozygous for a knock-out allele are small and hypoactive and die within hours of birth displaying failure to suckle, progressive dehydration, and epidermal defects including a reddish, tight and wrinkled skin, hyperkeratosis, and impaired skin barrier function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21816 NCBI Gene Model | MGI Sequence Detail 13913 C57BL/6J ±  kb
    transcript NM_001161715 RefSeq | MGI Sequence Detail 2854 C57BL/6  
    polypeptide Q9JLF6 UniProt | EBI | MGI Sequence Detail 815 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      52 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 32

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15072, MGI:1916760
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:13218 Rajagopalan S, et al., Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6179-83
    • Latest
      J:253846 Wolf C, et al., ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C gamma1 and protein kinase C pathways. Sci Rep. 2016 Dec 22;6:39780

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory