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Tgm1
Gene Detail
Symbol

Name
ID
Tgm1
transglutaminase 1, K polypeptide
MGI:98730
Synonyms
2310004J08Rik, K polypeptide, protein-glutamine-gamma-glutamyltransferase, TGase 1, TG K
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:55700009-55713492 bp, - strand
From Ensembl annotation of GRCm38

  13484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 7 zebrafish

HCOP human homology predictions: TGM1
Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm1

Human
homologs
TGM1, transglutaminase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7051
neXtProt AC: NX_P22735

Human Synonyms: ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK

Human Chr (Location): 14q11.2; chr14:24249114-24263210 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TGM1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Newborn mice homozygous for a knock-out allele are small and hypoactive and die within hours of birth displaying failure to suckle, progressive dehydration, and epidermal defects including a reddish, tight and wrinkled skin, hyperkeratosis, and impaired skin barrier function.
 
Human Diseases Modeled in Mice Using Tgm1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Tgm1 interacts with 34 markers (Mir22, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (103)    Tissues (96)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tgm1 ; ZFIN tgm1    NEW 
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(31)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022218 (Evidence)
Entrez Gene 21816 (Evidence)
UniGene 41964
DFCI TC1584232, TC1645336
DoTS DT.101370884, DT.40135751, DT.99847079
NIA Mouse Gene Index U035586
EC 2.3.2.13
Consensus CDS Project CCDS36932.1
International Mouse Phenotyping Consortium Status Tgm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022218 Ensembl Gene Model | MGI Sequence Detail 13484 C57BL/6J ±  kb
transcript ENSMUST00000168729 Ensembl | MGI Sequence Detail 2852 Not Applicable 
polypeptide ENSMUSP00000128090 Ensembl | MGI Sequence Detail 815 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016292 protein-glutamine gamma-glutamyltransferase K
References
(Earliest) J:13218 Rajagopalan S, et al., Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6179-83
(Latest) J:214170 Itoh M, et al., Variations in both TG1 and TG2 isozyme-specific in situ activities and protein expressions during mouse embryonic development. J Histochem Cytochem. 2013 Nov;61(11):793-801
All references(51)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15072, MGI:1916760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory