Tgfb2
Gene Detail

Symbol Name ID

Tgfb2 transforming growth factor, beta 2 MGI:98726

Synonyms

Tgfb-2, Tgf-beta2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

89.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr1:186623186-186705992 bp, - strand From NCBI annotation of GRCm38   82807 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb2

Human homologs

Human Homolog		TGFB2, transforming growth factor, beta 2
NCBI Gene ID		7042
neXtProt AC		NX_P61812
Human Synonyms		LDS4, TGF-beta2
Human Chr (Location)		1q41; chr1:218518676-218617961 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TGFB2

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a targeted null mutation exhibit defects of the heart, lungs, skull, limbs, spinal column, eyes, inner ears, and urogenital system, and perinatal mortality. Heterozygotes show abnormalities of the Cowpers' gland and intestinal mucosa.

 
Human Diseases Modeled Using Mouse Tgfb2 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (107 annotations)

Process	activation-induced cell death of T cells, activation of protein kinase activity, ...
Component	axon, basement membrane, ...
Function	beta-amyloid binding, growth factor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (135 records)
Data Summary: Results (512)    Tissues (359)    Images (164)
Theiler Stages: 1, 2, 3, 4, 7, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	121
RNA in situ	325
Northern blot	41
RT-PCR	23
RNase protection	2

cDNA source data(97)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(116) Genomic(1) cDNA(101) Primer pair(8) Other(6)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000039239 (Evidence)
Entrez Gene	21808 (Evidence)
UniGene	18213
DFCI	TC1574828, TC1632269, TC1655922
DoTS	DT.101370722, DT.110895060, DT.91311064
NIA Mouse Gene Index	U022179
Consensus CDS Project	CCDS15601.1
International Mouse Knockout Project Status	Tgfb2

Sequences

Length	Strain/Species
genomic	21808	NCBI Gene Model | MGI Sequence Detail	82807	C57BL/6J
transcript	NM_009367	RefSeq | MGI Sequence Detail	4725	C57BL/6
polypeptide	P27090	UniProt | EBI | MGI Sequence Detail	414	Not Applicable

All sequences(31) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(231 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016319	Transforming growth factor-beta
InterPro	IPR003940	Transforming growth factor, beta 2
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000183	TGF-beta 2

Graphical View of Protein Domain Structure

References

(Earliest) J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
(Latest) J:194131 Sugiyama D, et al., TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
All references(245)

Other accession IDs

MGD-MRK-15065, MGD-MRK-15068, MGI:2138633