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Tgfb2 Gene Detail
Summary
  • Symbol
    Tgfb2
  • Name
    transforming growth factor, beta 2
  • Synonyms
    Tgfb-2, Tgf-beta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98726
    NCBI Gene: 21808
  • Gene Overview
    MyGene.info: TGFB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:186622792-186705989 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83198 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 89.95 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    TGFB2, transforming growth factor beta 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TGFB2, transforming growth factor beta 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G-TSF, LDS4, TGF-beta2
  • Links
    NCBI Gene ID: 7042
    neXtProt AC: NX_P61812
    UniProt: P61812

  • Chr Location
    1q41; chr1:218345334-218444619 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tgfb2 mouse models; 1 with human TGFB2 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    122 phenotypes from 1 allele in 5 genetic backgrounds
    35 phenotypes from multigenic genotypes
    2 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects of the heart, lungs, skull, limbs, spinal column, eyes, inner ears, and urogenital system, and perinatal mortality. Heterozygotes show abnormalities of the Cowpers' gland and intestinal mucosa.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000050852 VEGA Gene Model | MGI Sequence Detail 83198 C57BL/6J ±  kb
    transcript OTTMUST00000128837 VEGA | MGI Sequence Detail 3485 Not Applicable  
    polypeptide OTTMUSP00000069283 VEGA | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      269 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • PDB
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR001111 TGF-beta, propeptide
      IPR016319 Transforming growth factor-beta
      IPR003940 Transforming growth factor, beta 2
      IPR017948 Transforming growth factor beta, conserved site
      IPR001839 Transforming growth factor-beta, C-terminal
      IPR015615 Transforming growth factor-beta-related
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 1
      cDNA 104
      Primer pair 10
      Other 12

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15065, MGD-MRK-15068, MGI:2138633
    References
    more
    • Summaries
      All 341
      Developmental Gene Expression 190
      Diseases 2
      Gene Ontology 30
      Phenotypes 53
    • Earliest
      J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
    • Latest
      J:256746 Wang X, et al., A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye. Biochim Biophys Acta. 2017 Jan;1863(1):60-67

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory