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Tgfb2
Gene Detail
Symbol

Name
ID
Tgfb2
transforming growth factor, beta 2
MGI:98726
Synonyms
Tgfb-2, Tgf-beta2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
89.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr1:186622792-186705989 bp, - strand
From VEGA annotation of GRCm38

  83198 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TGFB2
Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb2

Human
homologs
TGFB2, transforming growth factor, beta 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7042
neXtProt AC: NX_P61812

Human Synonyms: LDS4, TGF-beta2

Human Chr (Location): 1q41; chr1:218345334-218444619 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TGFB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit defects of the heart, lungs, skull, limbs, spinal column, eyes, inner ears, and urogenital system, and perinatal mortality. Heterozygotes show abnormalities of the Cowpers' gland and intestinal mucosa.
 
Human Diseases Modeled in Mice Using Tgfb2 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Tgfb2 interacts with 296 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (122 annotations)
Process activation of protein kinase activity, axon guidance, ...
Component axon, basement membrane, ...
Function beta-amyloid binding, cytokine activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (167 records)
Data Summary: Results (664)    Tissues (443)    Images (193)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 164
RNA in situ 432
Northern blot 41
RT-PCR 25
RNase protection 2
cDNA source data(98)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TGFB2 ; Xenbase tgfb2 ; ZFIN tgfb2    NEW 
Molecular
reagents
All nucleic(119) Genomic(1) cDNA(102) Primer pair(9) Other(7)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000050852 (Evidence)
Ensembl Gene Model ENSMUSG00000039239 (Evidence)
Entrez Gene 21808 (Evidence)
UniGene 18213
DFCI TC1574828, TC1632269, TC1655922
DoTS DT.101370722, DT.110895060, DT.91311064
NIA Mouse Gene Index U022179
Consensus CDS Project CCDS15601.1
International Mouse Phenotyping Consortium Status Tgfb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050852 VEGA Gene Model | MGI Sequence Detail 83198 C57BL/6J ±  kb
transcript OTTMUST00000128837 VEGA | MGI Sequence Detail 3485 Not Applicable 
polypeptide OTTMUSP00000069283 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(263 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016319 Transforming growth factor-beta
InterPro IPR003940 Transforming growth factor, beta 2
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000183 TGF-beta 2
References
(Earliest) J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
(Latest) J:220322 Kutchuk L, et al., Muscle composition is regulated by a Lox-TGFbeta feedback loop. Development. 2015 Mar 1;142(5):983-93
All references(286)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15065, MGD-MRK-15068, MGI:2138633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory