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Tgfb2 Gene Detail
Summary
  • Symbol
    Tgfb2
  • Name
    transforming growth factor, beta 2
  • Synonyms
    Tgfb-2, Tgf-beta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98726
    NCBI Gene: 21808
  • Gene Overview
    MyGene.info: TGFB2
Location & Maps
more
  • Sequence Map
    Chr1:186622792-186705989 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      83198 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TGFB2, transforming growth factor beta 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TGFB2, transforming growth factor beta 2
    Orthology source: HomoloGene
  • Synonyms
    LDS4, TGF-beta2
  • Links
    NCBI Gene ID: 7042
    neXtProt AC: NX_P61812

  • Chr Location
    1q41; chr1:218345334-218444619 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Tgfb2 mouse models; 1 with human TGFB2 associations

Human Disease Mouse Models
       Loeys-Dietz Syndrome 1; LDS1   OMIM: 609192 View 2 models
Peters Anomaly   OMIM: 604229 View 1 model
       Loeys-Dietz Syndrome 4; LDS4   OMIM: 614816
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    122 phenotypes from 1 allele in 5 genetic backgrounds
    34 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    5
  • Transgenic
    3
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit defects of the heart, lungs, skull, limbs, spinal column, eyes, inner ears, and urogenital system, and perinatal mortality. Heterozygotes show abnormalities of the Cowpers' gland and intestinal mucosa.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050852 VEGA Gene Model | MGI Sequence Detail 83198 C57BL/6J ±  kb
transcript OTTMUST00000128837 VEGA | MGI Sequence Detail 3485 Not Applicable  
polypeptide OTTMUSP00000069283 VEGA | MGI Sequence Detail 442 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    269 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000000183 TGF-beta 2
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR016319 Transforming growth factor-beta
    IPR003940 Transforming growth factor, beta 2
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
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  • All nucleic 119
    Genomic 1
    cDNA 102
    Primer pair 9
    Other 7

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-15065, MGD-MRK-15068, MGI:2138633
References
more
  • Summaries
    All 291
    Developmental Gene Expression 170
    Diseases 3
    Gene Ontology 27
    Phenotypes 51
  • Earliest
    J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
  • Latest
    J:228888 Waning DL, et al., Excess TGF-beta mediates muscle weakness associated with bone metastases in mice. Nat Med. 2015 Nov;21(11):1262-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory