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Tgfb2
Gene Detail
Symbol

Name
ID
Tgfb2
transforming growth factor, beta 2
MGI:98726
Synonyms
Tgfb-2, Tgf-beta2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
89.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr1:186623186-186705992 bp, - strand
From Ensembl annotation of GRCm38

  82807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transforming growth factor-beta
Gene Tree: Tgfb2

Human
homologs
Human Homolog TGFB2, transforming growth factor, beta 2
NCBI Gene ID 7042
neXtProt AC  NX_P61812
Human Synonyms  LDS4, TGF-beta2
Human Chr (Location)  1q41; chr1:218345334-218444619 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TGFB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit defects of the heart, lungs, skull, limbs, spinal column, eyes, inner ears, and urogenital system, and perinatal mortality. Heterozygotes show abnormalities of the Cowpers' gland and intestinal mucosa.
 
Human Diseases Modeled Using Mouse Tgfb2 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Tgfb2 interacts with 296 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (120 annotations)
Process activation of protein kinase activity, axon guidance, ...
Component axon, basement membrane, ...
Function beta-amyloid binding, cytokine activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (150 records)
Data Summary: Results (624)    Tissues (423)    Images (192)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 126
RNA in situ 432
Northern blot 41
RT-PCR 23
RNase protection 2
cDNA source data(98)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) Genomic(1) cDNA(102) Primer pair(8) Other(7)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000039239 (Evidence)
Entrez Gene21808 (Evidence)
UniGene18213
DFCITC1574828, TC1632269, TC1655922
DoTSDT.101370722, DT.110895060, DT.91311064
NIA Mouse Gene IndexU022179
Consensus CDS ProjectCCDS15601.1
International Mouse Knockout Project StatusTgfb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039239 Ensembl Gene Model | MGI Sequence Detail 82807 C57BL/6J ±  kb
transcript ENSMUST00000045288 Ensembl | MGI Sequence Detail 4725 Not Applicable 
polypeptide ENSMUSP00000043849 Ensembl | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016319 Transforming growth factor-beta
InterPro IPR003940 Transforming growth factor, beta 2
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000183 TGF-beta 2
References
(Earliest) J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(267)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15065, MGD-MRK-15068, MGI:2138633

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory