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Tgfa Gene Detail
Summary
  • Symbol
    Tgfa
  • Name
    transforming growth factor alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:98724
    NCBI Gene: 21802
  • Gene Overview
    MyGene.info: TGFA
Location & Maps
more
  • Sequence Map
    Chr6:86195223-86275719 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80497 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.62 cM
  • Mapping Data
    27 experiments
Homology
more
  • Human Ortholog
    TGFA, transforming growth factor alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TGFA, transforming growth factor alpha
    Orthology source: HomoloGene
  • Synonyms
    TFGA
  • Links
    NCBI Gene ID: 7039
    neXtProt AC: NX_P01135

  • Chr Location
    2p13; chr2:70447280-70554015 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2431
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
  • HCOP
    human homology predictions: TGFA
  • Gene Tree
Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 4 alleles in 4 genetic backgrounds
    98 phenotypes from multigenic genotypes
    1 images
    154 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Gene trapped
    1
  • Spontaneous
    3
  • Targeted
    2
  • Transgenic
    18
  • Genomic Mutations
    1 involving Tgfa
  • Incidental Mutations
Homozygous mutants have curly vibrissae, wavy hair with misaligned hair follicles, reduced body weight, and eye defects including open eyelids at birth, corneal scarring and microphthalmia. Some heterozygotes show mild forms of the eye abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049992 VEGA Gene Model | MGI Sequence Detail 80497 C57BL/6J ±  kb
transcript OTTMUST00000127208 VEGA | MGI Sequence Detail 4527 Not Applicable  
polypeptide OTTMUSP00000068692 VEGA | MGI Sequence Detail 159 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    516 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016285 protransforming growth factor alpha
  • InterPro Domains
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR015497 Epidermal growth factor receptor ligand
Molecular
Reagents
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  • All nucleic 224
    Genomic 6
    cDNA 207
    Primer pair 9
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-15062, MGD-MRK-15421, MGD-MRK-15423
References
more
  • Summaries
    All 212
    Developmental Gene Expression 50
    Diseases 3
    Gene Ontology 9
    Phenotypes 154
  • Earliest
    J:13034 Crew FAE, Waved: an autosomal recessive coat form character in the mouse. J Genet. 1933;27:95-96
  • Latest
    J:232444 Li S, et al., Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory