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Tgfa
Gene Detail
Symbol

Name
ID
Tgfa
transforming growth factor alpha
MGI:98724
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(27)
Sequence Map
Chr6:86195251-86275639 bp, + strand
From VEGA annotation of GRCm38

  80389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2431  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Tgfa

Human
homologs
Human Homolog   TGFA, transforming growth factor, alpha
NCBI Gene ID 7039
neXtProt AC  NX_P01135
Human Synonyms  TFGA
Human Chr (Location)  2p13; chr2:70447280-70554015 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Spontaneous(3) Targeted(2) Transgenic(5)
Genomic Mutations involving Tgfa (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have curly vibrissae, wavy hair with misaligned hair follicles, reduced body weight, and eye defects including open eyelids at birth, corneal scarring and microphthalmia. Some heterozygotes show mild forms of the eye abnormalities.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Tgfa interacts with 328 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process activation of MAPK activity, angiogenesis, ...
Component basolateral plasma membrane, cell surface, ...
Function epidermal growth factor receptor binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (298)    Tissues (94)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 110
Northern blot 10
RT-PCR 171
cDNA source data(205)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(222) Genomic(6) cDNA(207) Primer pair(7) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000049992 (Evidence)
Ensembl Gene ModelENSMUSG00000029999 (Evidence)
Entrez Gene21802 (Evidence)
UniGene137222
DoTSDT.40150470, DT.60104389
NIA Mouse Gene IndexU007112
Consensus CDS ProjectCCDS51832.1
International Mouse Knockout Project StatusTgfa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049992 VEGA Gene Model | MGI Sequence Detail 80389 C57BL/6J ±  kb
transcript OTTMUST00000127208 VEGA | MGI Sequence Detail 4183 Not Applicable 
polypeptide OTTMUSP00000068692 VEGA | MGI Sequence Detail 159 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(518 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015497 Epidermal growth factor receptor ligand
Protein Ontology PR:000016285 protransforming growth factor alpha
References
(Earliest) J:13034 Crew FAE, Waved: an autosomal recessive coat form character in the mouse. J Genet. 1933;27:95-96
(Latest) J:211269 Hosur V, et al., Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2200-9
All references(212)
Other
accession IDs
MGD-MRK-15062, MGD-MRK-15421, MGD-MRK-15423

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory