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Ift88
Gene Detail
Symbol

Name
ID
Ift88
intraflagellar transport 88
MGI:98715
Synonyms
fxo, IFT88, Oak Ridge polycystic kidneys, orpk, polaris, Tg737, Tg737Rpw, TgN737Rpw, Ttc10
Feature Type
protein coding gene
Genetic Map
Chromosome 14
30.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:57424062-57517936 bp, + strand
From VEGA annotation of GRCm38

  93875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4761  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IFT88
Gene Tree: Ift88

Human
homologs
IFT88, intraflagellar transport 88
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8100
neXtProt AC: NX_Q13099

Human Synonyms: D13S1056E, DAF19, hTg737, TG737, TTC10

Human Chr (Location): 13q12.1; chr13:20566446-20691437 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(2) Gene trapped(1) Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display early to mid-gestation lethality, random patterning of the left-right body axis, neural tube defects, pericardial sac expansion, enlarged limb buds, polydactyly, and absent embryonic node cilia.
 
Human Diseases Modeled in Mice Using Ift88 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ift88 interacts with 126 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process anterior/posterior pattern specification, brain development, ...
Component acrosomal membrane, apical part of cell, ...
Function kinesin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (27)    Tissues (17)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 4
In situ reporter (knock in) 5
Northern blot 14
RT-PCR 2
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ift88 ; ZFIN ift88    NEW 
Molecular
reagents
All nucleic(42) Genomic(6) cDNA(35) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026733 (Evidence)
Ensembl Gene Model ENSMUSG00000040040 (Evidence)
Entrez Gene 21821 (Evidence)
UniGene 4653
DFCI TC1579959
DoTS DT.101715261, DT.40185677
NIA Mouse Gene Index U015690
Consensus CDS Project CCDS36937.2
International Mouse Phenotyping Consortium Status Ift88
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026733 VEGA Gene Model | MGI Sequence Detail 93875 C57BL/6J ±  kb
transcript OTTMUST00000065922 VEGA | MGI Sequence Detail 3088 Not Applicable 
polypeptide OTTMUSP00000032923 VEGA | MGI Sequence Detail 825 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(13) UniProt(5)
Polymorphisms
SNPs within 2kb(288 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000008940 intraflagellar transport protein 88
References
(Earliest) J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
(Latest) J:221536 Berbari NF, et al., Hippocampal and cortical primary cilia are required for aversive memory in mice. PLoS One. 2014;9(9):e106576
All references(157)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-15052, MGI:2145834

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory