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Ift88
Gene Detail
 Symbol
Name
ID
Ift88
intraflagellar transport 88
MGI:98715
Synonyms fxo, IFT88, Oak Ridge polycystic kidneys, orpk, polaris, Tg737, Tg737Rpw, TgN737Rpw, Ttc10
Feature Type protein coding gene
Genetic Map
Chromosome 14
30.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:57424062-57517936 bp, + strand
From VEGA annotation of GRCm38

  93875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4761  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ift88

Human
homologs
Human Homolog IFT88, intraflagellar transport 88
NCBI Gene ID 8100
neXtProt AC  NX_Q13099
Human Synonyms  D13S1056E, DAF19, hTg737, TG737, TTC10
Human Chr (Location)  13q12.1; chr13:20566446-20691437 (+)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Chemically induced (ENU)(2) Gene trapped(1) Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display early to mid-gestation lethality, random patterning of the left-right body axis, neural tube defects, pericardial sac expansion, enlarged limb buds, polydactyly, and absent embryonic node cilia.
 
Human Diseases Modeled Using Mouse Ift88 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process anterior/posterior pattern specification, brain development, ...
Component acrosomal membrane, apical part of cell, ...
Function kinesin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (11)    Tissues (7)    Images (2)
Theiler Stages: 9, 11, 13, 26, 28
Assay TypeResults
In situ reporter (knock in) 5
Northern blot 4
RT-PCR 2
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) Genomic(6) cDNA(33) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026733 (Evidence)
Ensembl Gene ModelENSMUSG00000040040 (Evidence)
Entrez Gene21821 (Evidence)
UniGene4653
DFCITC1579959
DoTSDT.101715261, DT.40185677
NIA Mouse Gene IndexU015690
Consensus CDS ProjectCCDS36937.2
International Mouse Knockout Project StatusIft88
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026733 VEGA Gene Model | MGI Sequence Detail 93875 C57BL/6J ±  kb
transcript OTTMUST00000065922 VEGA | MGI Sequence Detail 3088 Not Applicable 
polypeptide OTTMUSP00000032923 VEGA | MGI Sequence Detail 825 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(9) UniProt(5)
Polymorphisms SNPs within 2kb(288 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000008940 intraflagellar transport protein 88
References (Earliest) J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
(Latest) J:210639 Mitchell EH, et al., Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells. Cilia. 2014;3(1):4
All references(146)
Other
accession IDs
MGD-MRK-15052, MGI:2145834

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory