Ift88
Gene Detail

Symbol Name ID

Ift88 intraflagellar transport 88 MGI:98715

Synonyms

fxo, IFT88, Oak Ridge polycystic kidneys, orpk, polaris, Tg737, Tg737Rpw, TgN737Rpw, Ttc10

Feature Type

protein coding gene

Genetic Map

Chromosome 14

30.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:57424062-57517936 bp, + strand From VEGA annotation of GRCm38   93875 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4761  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ift88

Human homologs

Human Homolog		IFT88, intraflagellar transport 88 homolog (Chlamydomonas)
NCBI Gene ID		8100
neXtProt AC		NX_Q13099
Human Synonyms		D13S1056E, DAF19, hTg737, TG737, TTC10
Human Chr (Location)		13q12.1; chr13:21141208-21265576 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(1) Transgenic(1) Chemically induced(2)
 

Mice homozygous for a null allele display early to mid-gestation lethality, random patterning of the left-right body axis, neural tube defects, pericardial sac expansion, enlarged limb buds, polydactyly, and absent embryonic node cilia.

 
Human Diseases Modeled Using Mouse Ift88 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	anterior/posterior pattern specification, brain development, ...
Component	apical part of cell, axoneme, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (11)    Tissues (7)    Images (2)
Theiler Stages: 9, 11, 13, 26, 28

Assay Type	Results
In situ reporter (knock in)	5
Northern blot	4
RT-PCR	2

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(6) cDNA(33) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026733 (Evidence)
Ensembl Gene Model	ENSMUSG00000040040 (Evidence)
Entrez Gene	21821 (Evidence)
UniGene	4653
DFCI	TC1579959
DoTS	DT.101715261, DT.40185677
NIA Mouse Gene Index	U015690
Consensus CDS Project	CCDS36937.2
International Mouse Knockout Project Status	Ift88

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026733	VEGA Gene Model | MGI Sequence Detail	93875	C57BL/6J
transcript	OTTMUST00000065922	VEGA | MGI Sequence Detail	3088	Not Applicable
polypeptide	OTTMUSP00000032923	VEGA | MGI Sequence Detail	825	Not Applicable

All sequences(40) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(262 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
Protein Ontology	PR:000008940	intraflagellar transport protein 88

References

(Earliest) J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(130)

Other accession IDs

MGD-MRK-15052, MGI:2145834