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Itpr3
Gene Detail
Symbol

Name
ID
Itpr3
inositol 1,4,5-triphosphate receptor 3
MGI:96624
Synonyms
Ip3r3, Itpr-3, tf
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(64)
Sequence Map
Chr17:27057304-27122223 bp, + strand
From VEGA annotation of GRCm38

  64920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Itpr3

Human
homologs
Human Homolog ITPR3, inositol 1,4,5-trisphosphate receptor, type 3
NCBI Gene ID 3710
neXtProt AC  NX_Q14573
Human Synonyms  IP3R, IP3R3
Human Chr (Location)  6p21; chr6:33621379-33696574 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITPR3
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(35) Radiation induced(1) Spontaneous(3) Targeted(3)
Genomic Mutations involving Itpr3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference.
 
Phenotype Images(1)
Interactions
Itpr3 interacts with 171 markers (Mir18, Mir18b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component apical part of cell, brush border, ...
Function calcium channel activity, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (146)    Tissues (24)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
RT-PCR 2
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(96) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031360 (Evidence)
Ensembl Gene ModelENSMUSG00000042644 (Evidence)
Entrez Gene16440 (Evidence)
UniGene458106
DFCITC1575369, TC1609334
DoTSDT.531202, DT.94166633
NIA Mouse Gene IndexU017725
PDB3JRR
Consensus CDS ProjectCCDS28560.1
International Mouse Knockout Project StatusItpr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031360 VEGA Gene Model | MGI Sequence Detail 64920 C57BL/6J ±  kb
transcript OTTMUST00000077693 VEGA | MGI Sequence Detail 8990 Not Applicable 
polypeptide OTTMUSP00000041150 VEGA | MGI Sequence Detail 2670 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(604 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
InterPro IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
InterPro IPR000699 Intracellular calcium-release channel
InterPro IPR005821 Ion transport domain
InterPro IPR016093 MIR motif
InterPro IPR015925 Ryanodine receptor-related
InterPro IPR013662 RyR/IP3R Homology associated domain
Protein Ontology PR:000009160 inositol 1,4,5-trisphosphate receptor type 3
References
(Earliest) J:273 Lyon MF, Hereditary hair loss in the tufted mutant of the house mouse. J Hered. 1956;47:101-3
(Latest) J:213173 Han S, et al., Enhancement of inhibitory neurotransmission by GABAA receptors having alpha2,3-subunits ameliorates behavioral deficits in a mouse model of autism. Neuron. 2014 Mar 19;81(6):1282-9
All references(142)
Other
accession IDs
MGD-MRK-11440, MGD-MRK-11507, MGD-MRK-11509, MGD-MRK-15043, MGI:98711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory