Itpr3
Gene Detail

Symbol Name ID

Itpr3 inositol 1,4,5-triphosphate receptor 3 MGI:96624

Synonyms

Ip3r3, Itpr-3, tf

Feature Type

protein coding gene

Genetic Map

Chromosome 17

13.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(64)

Sequence Map

Chr17:27057304-27122223 bp, + strand From VEGA annotation of GRCm38   64920 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Itpr3

Human homologs

Human Homolog		ITPR3, inositol 1,4,5-trisphosphate receptor, type 3
NCBI Gene ID		3710
neXtProt AC		NX_Q14573
Human Synonyms		IP3R, IP3R3
Human Chr (Location)		6p21; chr6:33589156-33664351 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ITPR3

Alleles and phenotypes

All alleles(43) : Targeted(3) Gene trapped(35) Spontaneous(3) Other(2)
 

Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (57 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	apical part of cell, brush border, ...
Function	calcium channel activity, calcium ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (146)    Tissues (24)    Images (21)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	144
RT-PCR	2

cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(97) cDNA(96) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031360 (Evidence)
Ensembl Gene Model	ENSMUSG00000042644 (Evidence)
Entrez Gene	16440 (Evidence)
UniGene	458106
DFCI	TC1575369, TC1609334
DoTS	DT.531202, DT.94166633
NIA Mouse Gene Index	U017725
PDB	3JRR
Consensus CDS Project	CCDS28560.1
International Mouse Knockout Project Status	Itpr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031360	VEGA Gene Model | MGI Sequence Detail	64920	C57BL/6J
transcript	OTTMUST00000077693	VEGA | MGI Sequence Detail	8990	Not Applicable
polypeptide	OTTMUSP00000041150	VEGA | MGI Sequence Detail	2670	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(309 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000493	Inositol 1,4,5-trisphosphate-binding protein receptor
InterPro	IPR014821	Inositol 1,4,5-trisphosphate/ryanodine receptor
InterPro	IPR000699	Intracellular calcium-release channel
InterPro	IPR005821	Ion transport domain
InterPro	IPR016093	MIR motif
InterPro	IPR015925	Ryanodine receptor-related
InterPro	IPR013662	RyR/IP3R Homology associated domain
Protein Ontology	PR:000009160	inositol 1,4,5-trisphosphate receptor type 3

References

(Earliest) J:273 Lyon MF, Hereditary hair loss in the tufted mutant of the house mouse. J Hered. 1956;47:101-3
(Latest) J:195220 Karunakaran S, et al., Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake. Physiol Genomics. 2013 Mar 1;45(5):191-9
All references(136)

Other accession IDs

MGD-MRK-11440, MGD-MRK-11507, MGD-MRK-11509, MGD-MRK-15043, MGI:98711