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Itpr3
Gene Detail
Symbol

Name
ID
Itpr3
inositol 1,4,5-triphosphate receptor 3
MGI:96624
Synonyms
Ip3r3, Itpr-3, tf
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(64)
Sequence Map
Chr17:27057304-27122223 bp, + strand
From VEGA annotation of GRCm38

  64920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: ITPR3
Gene Tree: Itpr3

Human
homologs
ITPR3, inositol 1,4,5-trisphosphate receptor, type 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3710
neXtProt AC: NX_Q14573

Human Synonyms: IP3R, IP3R3

Human Chr (Location): 6p21; chr6:33621379-33696574 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ITPR3

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(35) Radiation induced(1) Spontaneous(3) Targeted(3)
Genomic Mutations involving Itpr3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference.
 
Phenotype Images(1)
Interactions
Itpr3 interacts with 171 markers (Mir18, Mir18b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component apical part of cell, brush border, ...
Function calcium channel activity, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (146)    Tissues (24)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
RT-PCR 2
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase itpr3    NEW 
Molecular
reagents
All nucleic(97) cDNA(96) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031360 (Evidence)
Ensembl Gene Model ENSMUSG00000042644 (Evidence)
Entrez Gene 16440 (Evidence)
UniGene 458106
DFCI TC1575369, TC1609334
DoTS DT.531202, DT.94166633
NIA Mouse Gene Index U017725
PDB 3JRR
Consensus CDS Project CCDS28560.1
International Mouse Phenotyping Consortium Status Itpr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031360 VEGA Gene Model | MGI Sequence Detail 64920 C57BL/6J ±  kb
transcript OTTMUST00000077693 VEGA | MGI Sequence Detail 8990 Not Applicable 
polypeptide OTTMUSP00000041150 VEGA | MGI Sequence Detail 2670 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(604 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
InterPro IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
InterPro IPR005821 Ion transport domain
InterPro IPR016093 MIR motif
InterPro IPR000699 RIH (RyR and IP3R Homology) domain
InterPro IPR015925 Ryanodine receptor-related
InterPro IPR013662 RyR/IP3R Homology associated domain
Protein Ontology PR:000009160 inositol 1,4,5-trisphosphate receptor type 3
References
(Earliest) J:273 Lyon MF, Hereditary hair loss in the tufted mutant of the house mouse. J Hered. 1956;47:101-3
(Latest) J:221545 Gogolla N, et al., Sensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014 Aug 20;83(4):894-905
All references(144)
Other
accession IDs
MGD-MRK-11440, MGD-MRK-11507, MGD-MRK-11509, MGD-MRK-15043, MGI:98711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory