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Tek Gene Detail
Summary
  • Symbol
    Tek
  • Name
    TEK receptor tyrosine kinase
  • Synonyms
    Cd202b, Hyk, tie-2, Tie2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98664
    NCBI Gene: 21687
  • Gene Overview
    MyGene.info: TEK
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:94739289-94874976 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      135688 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 43.34 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    TEK, TEK receptor tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TEK, TEK receptor tyrosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD202B, GLC3E, TIE2, TIE-2, VMCM, VMCM1
  • Links
    NCBI Gene ID: 7010
    neXtProt AC: NX_Q02763
    UniProt: Q02763

  • Chr Location
    9p21.2; chr9:27109141-27230178 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TEK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 6 genetic backgrounds
    27 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000007859 VEGA Gene Model | MGI Sequence Detail 135688 C57BL/6J ±  kb
    transcript OTTMUST00000017987 VEGA | MGI Sequence Detail 4654 Not Applicable  
    polypeptide OTTMUSP00000008261 VEGA | MGI Sequence Detail 1123 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      743 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 3
      cDNA 57
      Primer pair 10
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-14991, MGD-MRK-16702, MGD-MRK-18601, MGI:2140157
    References
    more
    • Summaries
      All 285
      Developmental Gene Expression 170
      Gene Ontology 21
      Phenotypes 28
    • Earliest
      J:1682 Dumont DJ, et al., tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992 Aug;7(8):1471-80
    • Latest
      J:262224 Yin GN, et al., Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway. Diabetes. 2018 Jun;67(6):1149-1161

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory