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Tef
Gene Detail
 Symbol
Name
ID
Tef
thyrotroph embryonic factor
MGI:98663
Synonyms 2310028D20Rik
Feature Type protein coding gene
Genetic Map
Chromosome 15
38.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr15:81802421-81826861 bp, + strand
From VEGA annotation of GRCm38

  24441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31140  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tef

Human
homologs
Human Homolog TEF, thyrotrophic embryonic factor
NCBI Gene ID 7008
neXtProt AC  NX_Q10587
Human Chr (Location)  22q13.2; chr22:41367333-41399328 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Radiation induced(1) Targeted(2)
Genomic Mutations involving Tef (1)
Incidental mutations (data from APF )
 
Homozygous mutant are subject to seizures.
 
Interactions
Tef interacts with 333 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (33)    Tissues (24)    Images (2)
Theiler Stages: 2, 3, 4, 5, 19, 23, 28
Assay TypeResults
RNA in situ 25
RT-PCR 8
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(153) cDNA(152) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035246 (Evidence)
Ensembl Gene ModelENSMUSG00000022389 (Evidence)
Entrez Gene21685 (Evidence)
UniGene270278
DFCITC1576494, TC1581867, TC1638747, TC1640632, TC1650919, TC1756528
DoTSDT.101129608, DT.530255, DT.55186842, DT.94290935, DT.94290953
NIA Mouse Gene IndexU016469
Consensus CDS ProjectCCDS27671.2, CCDS27672.1
International Mouse Knockout Project StatusTef
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035246 VEGA Gene Model | MGI Sequence Detail 24441 C57BL/6J ±  kb
transcript OTTMUST00000089881 VEGA | MGI Sequence Detail 4079 Not Applicable 
polypeptide OTTMUSP00000049165 VEGA | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(9) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000016225 thyrotroph embryonic factor
References (Earliest) J:81277 Drolet DW, et al., TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 1991 Oct;5(10):1739-53
(Latest) J:171095 Gutierrez O, et al., A novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblasts. PLoS One. 2011;6(2):e17169
All references(55)
Other
accession IDs
MGD-MRK-14990, MGI:1914201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory