About   Help   FAQ
Dntt
Gene Detail
 Symbol
Name
ID
Dntt
deoxynucleotidyltransferase, terminal
MGI:98659
Synonyms Tdt
Feature Type protein coding gene
Genetic Map
Chromosome 19
34.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr19:41029275-41059523 bp, + strand
From Ensembl annotation of GRCm38

  30249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3014  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA nucleotidyltransferase
Gene Tree: Dntt

Human
homologs
Human Homolog DNTT, DNA nucleotidylexotransferase
NCBI Gene ID 1791
neXtProt AC  NX_P04053
Human Synonyms  TDT
Human Chr (Location)  10q23-q24; chr10:96304328-96338564 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in lack of "N" nucleotide insertions at the junctions of immunoglobulin and T cell receptor V(D)J rearrangements. Forced expression of terminal deoxynucleotidyl transferase in fetal thymus leads to decreased gamma-delta T cell number.
 
Interactions
Dntt interacts with 55 markers (Mir29b-1, Mir92-2, Mir138-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process DNA metabolic process, DNA modification, ...
Component cytoplasm, euchromatin, ...
Function DNA binding, DNA-directed DNA polymerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (28)    Tissues (14)    Images (1)
Theiler Stages: 16, 22, 23, 26, 27, 28
Assay TypeResults
Northern blot 9
Western blot 3
RT-PCR 16
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(6) cDNA(26) Primer pair(3) Other(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000025014 (Evidence)
Entrez Gene21673 (Evidence)
UniGene25620
DFCITC1593260, TC1595012, TC1605797, TC1634184
DoTSDT.101365184, DT.101365185
NIA Mouse Gene IndexU043726
EC2.7.7.31
PDB1JMS, 1KDH, 1KEJ, 4I2A, 4I2B, 4I2C, 4I2D, 4I2E, 4I2F, 4I2G, 4I2H, 4I2I, 4I2J, 4IQT, 4IQU, 4IQV, 4IQW, 4I27, 4I28, 4I29
Consensus CDS ProjectCCDS29807.1, CCDS37984.1
International Mouse Knockout Project StatusDntt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025014 Ensembl Gene Model | MGI Sequence Detail 30249 C57BL/6J ±  kb
transcript ENSMUST00000051806 Ensembl | MGI Sequence Detail 2128 Not Applicable 
polypeptide ENSMUSP00000062078 Ensembl | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms RFLP(9) : SNPs within 2kb(349 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR002054 DNA-directed DNA polymerase X
InterPro IPR027292 DNA nucleotidylexotransferase (TdT)
InterPro IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
InterPro IPR010996 DNA polymerase beta-like, N-terminal domain
InterPro IPR022312 DNA polymerase family X
InterPro IPR019843 DNA polymerase family X, binding site
InterPro IPR027421 DNA polymerase family X lyase domain
InterPro IPR018944 DNA polymerase lambda, fingers domain
InterPro IPR002934 Nucleotidyl transferase domain
Protein Ontology PR:000006611 DNA nucleotidylexotransferase
References (Earliest) J:22043 Landau NR, et al., Cloning of terminal transferase cDNA by antibody screening. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5836-40
(Latest) J:209818 Holodick NE, et al., B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location. J Immunol. 2014 Mar 1;192(5):2432-41
All references(81)
Other
accession IDs
MGD-MRK-14985, MGI:2147771

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory