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Dntt Gene Detail
Summary
  • Symbol
    Dntt
  • Name
    deoxynucleotidyltransferase, terminal
  • Synonyms
    Tdt
  • Feature Type
    protein coding gene
  • IDs
    MGI:98659
    NCBI Gene: 21673
Location & Maps
more
  • Sequence Map
    Chr19:41029275-41059523 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30249 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.32 cM
  • Mapping Data
    20 experiments
Homology
more
  • Human Ortholog
    DNTT, DNA nucleotidylexotransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNTT, DNA nucleotidylexotransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TDT
  • Links
    NCBI Gene ID: 1791
    neXtProt AC: NX_P04053

  • Chr Location
    10q23-q24; chr10:96304328-96338564 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in lack of "N" nucleotide insertions at the junctions of immunoglobulin and T cell receptor V(D)J rearrangements. Forced expression of terminal deoxynucleotidyl transferase in fetal thymus leads to decreased gamma-delta T cell number.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025014 Ensembl Gene Model | MGI Sequence Detail 30249 C57BL/6J ±  kb
transcript ENSMUST00000051806 Ensembl | MGI Sequence Detail 2128 Not Applicable  
polypeptide ENSMUSP00000062078 Ensembl | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    348 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 37
    Genomic 6
    cDNA 26
    Primer pair 3
    Other 2

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-14985, MGI:2147771
References
more
  • Summaries
    All 79
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:22043 Landau NR, et al., Cloning of terminal transferase cDNA by antibody screening. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5836-40
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory