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Tdgf1
Gene Detail
Symbol

Name
ID
Tdgf1
teratocarcinoma-derived growth factor 1
MGI:98658
Synonyms
CR1, cripto
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:110939603-110946158 bp, - strand
From VEGA annotation of GRCm38

  6556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: TDGF1
Protein SuperFamily: growth factor Cripto
Gene Tree: Tdgf1

Human
homologs
TDGF1, teratocarcinoma-derived growth factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6997
neXtProt AC: NX_P13385

Human Synonyms: CR, CRGF, CRIPTO

Human Chr (Location): 3p21.31; chr3:46574555-46582463 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TDGF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(81) : Gene trapped(73) Targeted(8)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for disruptions in this gene display abnormalities in rostral-caudal axis formation, embryonic development and heart development.
 
Phenotype Images(3)
Interactions
Tdgf1 interacts with 124 markers (Mir1a-1, Mir1a-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process activation of MAPK activity, anterior/posterior axis specification, ...
Component anchored component of membrane, apical plasma membrane, ...
Function coreceptor activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (77 records)
Data Summary: Results (141)    Tissues (49)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 75
RT-PCR 41
RNase protection 16
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tdgf1.1, tdgf1.2, tdgf1.3 ; ZFIN tdgf1    NEW 
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(27) Primer pair(4) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000052499 (Evidence)
Ensembl Gene Model ENSMUSG00000032494 (Evidence)
Entrez Gene 21667 (Evidence)
UniGene 5090
DFCI TC1580939, TC1595302
DoTS DT.110570999, DT.530602
PDB 2J5H
Consensus CDS Project CCDS40783.1
International Mouse Phenotyping Consortium Status Tdgf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052499 VEGA Gene Model | MGI Sequence Detail 6556 C57BL/6J ±  kb
transcript OTTMUST00000131653 VEGA | MGI Sequence Detail 1932 Not Applicable 
polypeptide OTTMUSP00000070340 VEGA | MGI Sequence Detail 171 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019011 Cryptic/Cripto, CFC domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR017047 Teratocarcinoma-derived growth factor Cripto
Protein Ontology PR:000034149 teratocarcinoma-derived growth factor
References
(Earliest) J:16797 Ciccodicola A, et al., Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J. 1989 Jul;8(7):1987-91
(Latest) J:218169 Donnison M, et al., Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015 Jan 1;397(1):77-88
All references(135)
Other
accession IDs
MGD-MRK-14984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory