Tdgf1
Gene Detail

Symbol Name ID

Tdgf1 teratocarcinoma-derived growth factor 1 MGI:98658

Synonyms

CR1, cripto

Feature Type

protein coding gene

Genetic Map

Chromosome 9

60.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:110939610-110946158 bp, - strand From Ensembl annotation of GRCm38   6549 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: growth factor Cripto
Gene Tree: Tdgf1

Human homologs

Human Homolog		TDGF1, teratocarcinoma-derived growth factor 1
NCBI Gene ID		6997
neXtProt AC		NX_P13385
Human Synonyms		CR, CRGF, CRIPTO
Human Chr (Location)		3p21.31; chr3:46616045-46623953 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TDGF1

Alleles and phenotypes

All alleles(81) : Targeted(8) Gene trapped(73)
 

Mice homozygous for disruptions in this gene display abnormalities in rostral-caudal axis formation, embryonic development and heart development.

 

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	activation of MAPK activity, anterior/posterior axis specification, ...
Component	anchored to membrane, apical plasma membrane, ...
Function	coreceptor activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (69 records)
Data Summary: Results (136)    Tissues (49)    Images (48)
Theiler Stages: 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 21, 22, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	70
RT-PCR	41
RNase protection	16

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(1) cDNA(11) Primer pair(4) Other(5)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032494 (Evidence)
Entrez Gene	21667 (Evidence)
DFCI	TC1580939, TC1595302
DoTS	DT.110570999, DT.530602
PDB	2J5H
Consensus CDS Project	CCDS40783.1
International Mouse Knockout Project Status	Tdgf1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032494	Ensembl Gene Model | MGI Sequence Detail	6549	C57BL/6J
transcript	ENSMUST00000035075	Ensembl | MGI Sequence Detail	1925	Not Applicable
polypeptide	ENSMUSP00000035075	Ensembl | MGI Sequence Detail	171	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019011	Cryptic/Cripto, CFC domain
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR017047	Teratocarcinoma-derived growth factor Cripto
Protein Ontology	PR:000034149	teratocarcinoma-derived growth factor

References

(Earliest) J:16797 Ciccodicola A, et al., Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J. 1989 Jul;8(7):1987-91
(Latest) J:192264 Guardiola O, et al., Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3231-40
All references(127)

Other accession IDs

MGD-MRK-14984