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Tdgf1
Gene Detail
Symbol

Name
ID
Tdgf1
teratocarcinoma-derived growth factor 1
MGI:98658
Synonyms
CR1, cripto
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:110939610-110946158 bp, - strand
From Ensembl annotation of GRCm38

  6549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2416  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: growth factor Cripto
Gene Tree: Tdgf1

Human
homologs
Human Homolog TDGF1, teratocarcinoma-derived growth factor 1
NCBI Gene ID 6997
neXtProt AC  NX_P13385
Human Synonyms  CR, CRGF, CRIPTO
Human Chr (Location)  3p21.31; chr3:46574555-46582463 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TDGF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(81) : Gene trapped(73) Targeted(8)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for disruptions in this gene display abnormalities in rostral-caudal axis formation, embryonic development and heart development.
 
Phenotype Images(3)
Interactions
Tdgf1 interacts with 124 markers (Mir1a-1, Mir1a-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process activation of MAPK activity, anterior/posterior axis specification, ...
Component anchored component of membrane, apical plasma membrane, ...
Function coreceptor activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (141)    Tissues (49)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 75
RT-PCR 41
RNase protection 16
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(27) Primer pair(4) Other(6)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032494 (Evidence)
Entrez Gene21667 (Evidence)
UniGene5090
DFCITC1580939, TC1595302
DoTSDT.110570999, DT.530602
PDB2J5H
Consensus CDS ProjectCCDS40783.1
International Mouse Knockout Project StatusTdgf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032494 Ensembl Gene Model | MGI Sequence Detail 6549 C57BL/6J ±  kb
transcript ENSMUST00000035075 Ensembl | MGI Sequence Detail 1925 Not Applicable 
polypeptide ENSMUSP00000035075 Ensembl | MGI Sequence Detail 171 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019011 Cryptic/Cripto, CFC domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR017047 Teratocarcinoma-derived growth factor Cripto
Protein Ontology PR:000034149 teratocarcinoma-derived growth factor
References
(Earliest) J:16797 Ciccodicola A, et al., Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J. 1989 Jul;8(7):1987-91
(Latest) J:209656 Jin JZ, et al., Analysis of Cripto expression during mouse cardiac myocyte differentiation. Int J Dev Biol. 2013;57(9-10):793-7
All references(134)
Other
accession IDs
MGD-MRK-14984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory