Phf1 Gene Detail

Summary

• Symbol
  Phf1
• Name
  PHD finger protein 1
• Synonyms
  D17Ertd455e, mPcl1, PHF2, Tctex3, Tctex-3

• Feature Type
  protein coding gene
• IDs
  MGI:98647
  NCBI Gene: 21652
• Gene Overview
  MyGene.info: PHF1
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr17:26933127-26937890 bp, + strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    4764 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 13.60 cM
• Mapping Data
  6 experiments

Homology

• Human Ortholog
  PHF1, PHD finger protein 1

• Vertebrate Orthologs
  9

• Human Ortholog
  PHF1, PHD finger protein 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  hPHF1, MTF2L2, PCL1, PHF2, TDRD19C
• Links
  HGNC:8919

  NCBI Gene ID: 5252

  neXtProt AC: NX_O43189

  UniProt: O43189

  
  
• Chr Location
  6p21.32; chr6:33410751-33416453 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 7567
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: PHF1
• Gene Tree
  Phf1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  6
• Gene trapped
  1
• Radiation induced
  2
• Targeted
  3
• Genomic Mutations
  2 involving Phf1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  17 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  20
• GO References
  6

• External Resources
  FuncBase

Expression

• Assay Results
  67
• Tissues
  65
• cDNA Data
  59
• Literature Summary
  5

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase phf1

Interactions

• Phf1 interacts with 119 markers (Mir7-1, Mir17, Mir20a, ...) View All

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  5
• UniProt
  1
• CCDS
  CCDS37518.1
• UniGene
  258953

• Ensembl
  ENSMUSG00000024193 (Evidence)
• NCBI Gene
  21652

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000024193	Ensembl Gene Model | MGI Sequence Detail	4764	C57BL/6J
transcript	ENSMUST00000073724	Ensembl | MGI Sequence Detail	2429	Not Applicable
polypeptide	ENSMUSP00000073402	Ensembl | MGI Sequence Detail	559	Not Applicable

Polymorphisms

• SNPs within 2kb
  64 from dbSNP Build 142

• PCR
  1

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000012636 PHD finger protein 1
  (term hierarchy)
• PDB
  5XFQ
• InterPro Domains
  IPR031202 PHD finger protein 1
  IPR025894 Polycomb-like MTF2 factor 2, C-terminal domain
  IPR002999 Tudor domain
  IPR011011 Zinc finger, FYVE/PHD-type
  IPR019787 Zinc finger, PHD-finger
  IPR001965 Zinc finger, PHD-type
  IPR019786 Zinc finger, PHD-type, conserved site
  IPR013083 Zinc finger, RING/FYVE/PHD-type

Molecular
Reagents

• All nucleic 65

  Genomic 3

  cDNA 59

  Primer pair 3

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-14954, MGD-MRK-14968, MGI:1196283, MGI:2147091

References

• Summaries
  All 46

  Developmental Gene Expression 5

  Gene Ontology 6

  Phenotypes 8
• Earliest
  J:608 Ha H, et al., Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12(4):318-32
• Latest
  J:196212 Ballare C, et al., Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65