Phf1
Gene Detail

Symbol Name ID

Phf1 PHD finger protein 1 MGI:98647

Synonyms

D17Ertd455e, mPcl1, PHF2, Tctex3, Tctex-3

Feature Type

protein coding gene

Genetic Map

Chromosome 17

13.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr17:26933127-26937890 bp, + strand From NCBI annotation of GRCm38   4764 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Phf1

Human homologs

Human Homolog		PHF1, PHD finger protein 1
NCBI Gene ID		5252
neXtProt AC		NX_O43189
Human Synonyms		hPHF1, MTF2L2, PCL1, PHF2, TDRD19C
Human Chr (Location)		6p21.3; chr6:33410996-33416453 (+)  GRCh38

Alleles and phenotypes

All alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cellular response to DNA damage stimulus, chromatin modification, ...
Component	cytoplasm, cytoskeleton, ...
Function	metal ion binding, methylated histone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (78)    Tissues (74)    Images (5)
Theiler Stages: 2, 3, 4, 5, 15, 17, 21, 23, 28

Assay Type	Results
RNA in situ	63
RT-PCR	15

cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(66) Genomic(3) cDNA(59) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024193 (Evidence)
Entrez Gene	21652 (Evidence)
UniGene	258953
DFCI	TC1578233, TC1676675
DoTS	DT.101366186, DT.532417, DT.97401679, DT.99858585
Consensus CDS Project	CCDS37518.1
International Mouse Knockout Project Status	Phf1

Sequences

Length	Strain/Species
genomic	21652	NCBI Gene Model | MGI Sequence Detail	4764	C57BL/6J
transcript	NM_009343	RefSeq | MGI Sequence Detail	2429	C57BL/6
polypeptide	Q9Z1B8	UniProt | EBI | MGI Sequence Detail	559	Not Applicable

All sequences(36) RefSeq(7) UniProt(1)

Polymorphisms

PCR(1) : SNPs within 2kb(63 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR025894	Polycomb-like MTF2 factor 2, C-terminal domain
InterPro	IPR002999	Tudor domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000012636	PHD finger protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:608 Ha H, et al., Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12(4):318-32
(Latest) J:196212 Ballare C, et al., Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65
All references(42)

Other accession IDs

MGD-MRK-14954, MGD-MRK-14968, MGI:1196283, MGI:2147091