Phf1 MGI Mouse Gene Detail - MGI:98647

Phf1 Gene Detail

Symbol

Phf1
Name

PHD finger protein 1
Synonyms

D17Ertd455e, mPcl1, PHF2, Tctex3, Tctex-3

Feature Type

protein coding gene
IDs

MGI:98647
NCBI Gene: 21652
Gene Overview

MyGene.info: PHF1

Sequence Map

Chr17:26933127-26937890 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4764 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.60 cM
Mapping Data

6 experiments

Human Ortholog

PHF1, PHD finger protein 1

Vertebrate Orthologs

9

Human Ortholog

PHF1, PHD finger protein 1
Orthology source: HomoloGene, HGNC
Synonyms

hPHF1, MTF2L2, PCL1, PHF2, TDRD19C
Links

HGNC:8919

NCBI Gene ID: 5252

neXtProt AC: NX_O43189

UniProt: O43189
Chr Location

6p21.32; chr6:33410751-33416453 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7567
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PHF1
Gene Tree

Phf1

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

6
Gene trapped

1
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Phf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

20
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

71
Tissues

69
cDNA Data

59
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Phf1 interacts with 119 markers (Mir7-1, Mir17, Mir20a, ...) View All

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All Sequences

29
RefSeq

5
UniProt

1
CCDS

CCDS37518.1
UniGene

258953

Ensembl

ENSMUSG00000024193 (Evidence)
NCBI Gene

21652

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024193	Ensembl Gene Model \| MGI Sequence Detail	4764	C57BL/6J	± kb
transcript	ENSMUST00000073724	Ensembl \| MGI Sequence Detail	2429	Not Applicable
polypeptide	ENSMUSP00000073402	Ensembl \| MGI Sequence Detail	559	Not Applicable

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SNPs within 2kb

64 from dbSNP Build 142

PCR

1

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UniProt

1 Sequence
Protein Ontology

PR:000012636 PHD finger protein 1

(term hierarchy)
InterPro Domains

IPR031202 PHD finger protein 1

IPR025894 Polycomb-like MTF2 factor 2, C-terminal domain

IPR002999 Tudor domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 66

Genomic 3

cDNA 59

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-14954, MGD-MRK-14968, MGI:1196283, MGI:2147091

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 8
Earliest

J:608 Ha H, et al., Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12(4):318-32
Latest

J:196212 Ballare C, et al., Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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