Phf1
Gene Detail

Symbol

Name
ID

Phf1
PHD finger protein 1
MGI:98647

Synonyms

D17Ertd455e, mPcl1, PHF2, Tctex3, Tctex-3

Feature Type

protein coding gene

Genetic Map

Chromosome 17
13.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr17:26933127-26937890 bp, + strand From Ensembl annotation of GRCm38   4764 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Phf1

Human
homologs

Human Homolog		PHF1, PHD finger protein 1
NCBI Gene ID		5252
neXtProt AC		NX_O43189
Human Synonyms		hPHF1, MTF2L2, PCL1, PHF2, TDRD19C
Human Chr (Location)		6p21.3; chr6:33410996-33416453 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Gene trapped(1) Radiation induced(2) Targeted(1)
Genomic Mutations involving Phf1 (2)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Phf1 interacts with 119 markers (Mir7-1, Mir17, Mir20a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	cellular response to DNA damage stimulus, chromatin modification, ...
Component	cytoplasm, cytoskeleton, ...
Function	chromatin binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (68)    Tissues (66)    Images (5)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	60
RT-PCR	8

cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(66) Genomic(3) cDNA(59) Primer pair(3) Other(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000024193 (Evidence)
Entrez Gene	21652 (Evidence)
UniGene	258953
DFCI	TC1578233, TC1676675
DoTS	DT.101366186, DT.532417, DT.97401679, DT.99858585
Consensus CDS Project	CCDS37518.1
International Mouse Knockout Project Status	Phf1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024193	Ensembl Gene Model | MGI Sequence Detail	4764	C57BL/6J
transcript	ENSMUST00000073724	Ensembl | MGI Sequence Detail	2429	Not Applicable
polypeptide	ENSMUSP00000073402	Ensembl | MGI Sequence Detail	559	Not Applicable

All sequences(39) RefSeq(9) UniProt(1)

Polymorphisms

PCR(1) : SNPs within 2kb(63 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR025894	Polycomb-like MTF2 factor 2, C-terminal domain
InterPro	IPR002999	Tudor domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000012636	PHD finger protein 1

References

(Earliest) J:608 Ha H, et al., Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12(4):318-32
(Latest) J:196212 Ballare C, et al., Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012 Dec;19(12):1257-65
All references(43)

Other
accession IDs

MGD-MRK-14954, MGD-MRK-14968, MGI:1196283, MGI:2147091