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Tcte1 Gene Detail
Summary
  • Symbol
    Tcte1
  • Name
    t-complex-associated testis expressed 1
  • Synonyms
    D17Sil1, Tcte-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98640
    NCBI Gene: 21645
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:45523434-45542679 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.54 cM, cytoband C
  • Mapping Data
    8 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98640
protein coding gene Chr17:45523434-45542680 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023789
protein coding gene Chr17:46539999-46560185 (+)
A/J MGP_AJ_G0023747
protein coding gene Chr17:45425242-45444386 (+)
AKR/J MGP_AKRJ_G0023718
protein coding gene Chr17:45734132-45757572 (+)
BALB/cJ MGP_BALBcJ_G0023751
protein coding gene Chr17:45314761-45334373 (+)
C3H/HeJ MGP_C3HHeJ_G0023515
protein coding gene Chr17:46446664-46469150 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024194
protein coding gene Chr17:48551064-48571691 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021644
protein coding gene Chr17:42221680-42241162 (+)
CAST/EiJ MGP_CASTEiJ_G0022996
protein coding gene Chr17:46544608-46564699 (+)
CBA/J MGP_CBAJ_G0023491
protein coding gene Chr17:50284303-50294809 (+)
DBA/2J MGP_DBA2J_G0023617
protein coding gene Chr17:44215514-44235390 (+)
FVB/NJ MGP_FVBNJ_G0023584
protein coding gene Chr17:43792770-43812051 (+)
LP/J MGP_LPJ_G0023698
protein coding gene Chr17:47183909-47206397 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023613
protein coding gene Chr17:49842993-49866748 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024239
protein coding gene Chr17:46095749-46121822 (+)
PWK/PhJ MGP_PWKPhJ_G0022741
protein coding gene Chr17:43522973-43543019 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022556
protein coding gene Chr17:42963471-42982913 (+)
WSB/EiJ MGP_WSBEiJ_G0023061
protein coding gene Chr17:46619258-46640265 (+)



Homology
more
  • Human Ortholog
    TCTE1, t-complex-associated-testis-expressed 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TCTE1, t-complex-associated-testis-expressed 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D6S46, DRC5, FAP155
  • Links
    NCBI Gene ID: 202500
    neXtProt AC: NX_Q5JU00
    UniProt: Q5JU00

  • Chr Location
    6p21.1; chr6:44280160-44297805 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8434
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TCTE1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Tcte1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male sterility characterized by asthenozoospermia and decreased ATP generation within sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 21645 NCBI Gene Model | MGI Sequence Detail 19246 C57BL/6J ±  kb
transcript NM_013688 RefSeq | MGI Sequence Detail 3074 C57BL/6  
polypeptide A6H639 UniProt | EBI | MGI Sequence Detail 498 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    Genomic 1
    cDNA 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14943, MGD-MRK-14946, MGD-MRK-4780
References
more
  • Summaries
    All 31
    Diseases 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:8839 Rappold GA, et al., Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island. EMBO J. 1987 Jul;6(7):1975-80
  • Latest
    J:243766 Castaneda JM, et al., TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Proc Natl Acad Sci U S A. 2017 Jul 03;114(27):E5370-E5378

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory