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Trbv15 Gene Detail
Summary
  • Symbol
    Trbv15
  • Name
    T cell receptor beta, variable 15
  • Synonyms
    Gm16775
  • Feature Type
    gene segment
  • IDs
    MGI:98586
    NCBI Gene: 100124679
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41141211-41141658 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98586
gene segment Chr6:41141188-41141658 (+)
129S1/SvImJ MGP_129S1SvImJ_G0002587
gene segment Chr6:39625957-39626427 (+)
A/J MGP_AJ_G0002558
gene segment Chr6:37895754-37896224 (+)
AKR/J MGP_AKRJ_G0002549
gene segment Chr6:39100345-39100815 (+)
BALB/cJ MGP_BALBcJ_G0002544
gene segment Chr6:38108538-38109008 (+)
C3H/HeJ MGP_C3HHeJ_G0002511
gene segment Chr6:39127680-39128150 (+)
C57BL/6NJ MGP_C57BL6NJ_G0002685
gene segment Chr6:40605829-40606299 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0002254
gene segment Chr6:35685826-35686296 (+)
CAST/EiJ MGP_CASTEiJ_G0002496
gene segment Chr6:39013567-39014037 (+)
CBA/J MGP_CBAJ_G0002510
gene segment Chr6:42252448-42252918 (+)
DBA/2J MGP_DBA2J_G0002514
gene segment Chr6:37710373-37710843 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0002593
gene segment Chr6:39632559-39633029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0002517
gene segment Chr6:44491403-44491873 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0002695
gene segment Chr6:39078306-39078776 (+)
PWK/PhJ MGP_PWKPhJ_G0002456
gene segment Chr6:37333759-37334229 (+)
SPRET/EiJ MGP_SPRETEiJ_G0002408
gene segment Chr6:38770666-38771136 (+)
WSB/EiJ MGP_WSBEiJ_G0002512
gene segment Chr6:39007648-39008118 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
Mice homozygous for a knock-in allele exhibit altered rearrangement and allelic exclusion of the nearest Vbeta segment in the double-negative compartment; however, feedback inhibition of Vbeta-to-DJbeta recombination remains intact in the double-positivecompartment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic 100124679 NCBI Gene Model | MGI Sequence Detail 448 C57BL/6J ±  kb
polypeptide A0A0A6YYE3 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
less
  • All nucleic 5
    Genomic 4
    cDNA 1
Other
Accession IDs
less
MGD-MRK-14878, MGI:4439699
References
more
  • Summaries
    All 13
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:8182 Behlke MA, et al., Murine T-cell receptor mutants with deletions of beta-chain variable region genes. Proc Natl Acad Sci U S A. 1986 Feb;83(3):767-71
  • Latest
    J:220526 Del Blanco B, et al., T-cell receptor alpha enhancer is inactivated in alphabeta T lymphocytes. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1744-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory