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Tcrb Complex/Cluster/Region Detail
Summary
  • Symbol
    Tcrb
  • Name
    T cell receptor beta chain
  • Synonyms
    TCRbeta, Tib
Location &
Maps
more
  • Sequence Map
    Chr6:40891296-41558371 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, cytoband A-C
  • Mapping Data
    68 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1902 from dbSNP Build 142
  • PCR
  • RFLP
Human Diseases
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  • Mutations/Alleles
    14 with disease annotations
  • References
    16 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 22 alleles in 13 genetic backgrounds
    276 phenotypes from multigenic genotypes
    2 images
    4577 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display thymic hypoplasia, impaired Tcrb V(D)J recombinations, and arrested alphabeta T cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    Sequences &
    Gene Models
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    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21577 NCBI Gene Model | MGI Sequence Detail 667076 C57BL/6J ±  kb
    transcript X00439 GenBank | EMBL | DDBJ | MGI Sequence Detail 389 Not Specified  
    For the selected sequence
    Molecular
    Reagents
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    • All nucleic 15
      Genomic 3
      cDNA 6
      Primer pair 4
      Other 2
    Other
    Accession IDs
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    MGD-MRK-14870, MGD-MRK-15107
    References
    more
    • Summaries
      All 4809
      Developmental Gene Expression 8
      Diseases 16
      Gene Ontology 17
      Phenotypes 4577
    • Earliest
      J:7353 Hedrick SM, et al., Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8-14;308(5955):149-53
    • Latest
      J:278512 Racioppi L, et al., CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nat Commun. 2019 Jun 4;10(1):2450

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory