Tcrb
Complex/Cluster/Region Detail

Symbol Name ID

Tcrb T cell receptor beta chain MGI:98578

Synonyms

TCRbeta, Tib

Feature Type

complex/cluster/region

Genetic Map

Chromosome 6
cytoband A-C

Mapping data(68)

Alleles and phenotypes

All alleles(19) : Targeted(16) Other(3)
 

Homozygous null mice display thymic hypoplasia, impaired Tcrb V(D)J recombinations, and arrested alphabeta T cell development.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cellular response to parathyroid hormone stimulus, positive regulation of calcium-mediated signaling, ...
Component	alpha-beta T cell receptor complex, external side of plasma membrane
Function	peptide binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (9)    Tissues (3)   
Theiler Stages: 21, 22, 23

Assay Type	Results
Northern blot	9

cDNA source data(3)

Molecular reagents

All nucleic(14) Genomic(3) cDNA(6) Primer pair(3) Other(2)

Other database links

Entrez Gene	21577 (Evidence)
DFCI	TC1757216
DoTS	DT.94306829, DT.94336872

Sequences

Length	Strain/Species
transcript	X00439	GenBank | EMBL | DDBJ | MGI Sequence Detail	389	Not Specified

All sequences(6) RefSeq(1)

Polymorphisms

All PCR and RFLP(16) : PCR(3) RFLP(13) SNPs(0 from dbSNP Build 128)

References

(Earliest) J:7353 Hedrick SM, et al., Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8-14;308(5955):149-53
(Latest) J:194523 Brady BL, et al., Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks. J Immunol. 2013 Apr 1;190(7):3256-66
All references(540)

Other accession IDs

MGD-MRK-14870, MGD-MRK-15107