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Tcrb Complex/Cluster/Region Detail
Summary
  • Symbol
    Tcrb
  • Name
    T cell receptor beta chain
  • Synonyms
    TCRbeta, Tib
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:98578
    NCBI Gene: 21577
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 6, cytoband A-C
  • Mapping Data
    68 experiments
Human Diseases
more
  • Diseases
    1 with Tcrb mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    19 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 22 alleles in 13 genetic backgrounds
    268 phenotypes from multigenic genotypes
    3820 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    102
  • Targeted
    16
  • Transgenic
    86
Homozygous null mice display thymic hypoplasia, impaired Tcrb V(D)J recombinations, and arrested alphabeta T cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
transcript X00439 GenBank | EMBL | DDBJ | MGI Sequence Detail 389 Not Specified  
For the selected sequence
Polymorphisms
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  • PCR
  • RFLP
Molecular
Reagents
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  • All nucleic 15
    Genomic 3
    cDNA 6
    Primer pair 4
    Other 2
Other
Accession IDs
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MGD-MRK-14870, MGD-MRK-15107
References
more
  • Summaries
    All 588
    Developmental Gene Expression 8
    Diseases 19
    Gene Ontology 15
    Phenotypes 3820
  • Earliest
    J:7353 Hedrick SM, et al., Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8-14;308(5955):149-53
  • Latest
    J:234783 Friesen TJ, et al., Recent thymic emigrants are tolerized in the absence of inflammation. J Exp Med. 2016 May 30;213(6):913-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory