Tcp1 MGI Mouse Gene Detail - MGI:98535

Symbol

Tcp1
Name

t-complex protein 1
Synonyms

c-cpn, CCT, Cct1, Ccta, p63, Tcp-1, Tp63, TRic

Feature Type

protein coding gene
IDs

MGI:98535
NCBI Gene: 21454
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:13135216-13143954 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.72 cM, cytoband A3-B
Mapping Data

42 experiments

SNPs within 2kb

48 from dbSNP Build 142
Strain Annotations

18
RFLP

12

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98535	protein coding gene	Chr17:13134588-13143954 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023154	protein coding gene	Chr17:10586739-10618978 (+)
A/J	MGP_AJ_G0023122	protein coding gene	Chr17:10417379-10426134 (+)
AKR/J	MGP_AKRJ_G0023086	protein coding gene	Chr17:10246832-10261087 (+)
BALB/cJ	MGP_BALBcJ_G0023122	protein coding gene	Chr17:10196276-10208865 (+)
C3H/HeJ	MGP_C3HHeJ_G0022885	protein coding gene	Chr17:10497116-10506131 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023565	protein coding gene	Chr17:10987344-11001617 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021043	protein coding gene	Chr17:4024762-4034797 (-)
CAST/EiJ	MGP_CASTEiJ_G0022399	protein coding gene	Chr17:10581250-10591104 (+)
CBA/J	MGP_CBAJ_G0022857	protein coding gene	Chr17:11406419-11415225 (+)
DBA/2J	MGP_DBA2J_G0022990	protein coding gene	Chr17:10053950-10062801 (+)
FVB/NJ	MGP_FVBNJ_G0022960	protein coding gene	Chr17:9990600-9999841 (+)
LP/J	MGP_LPJ_G0023062	protein coding gene	Chr17:10432205-10441515 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022979	protein coding gene	Chr17:11006428-11015239 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023591	protein coding gene	Chr17:10522023-10531677 (+)
PWK/PhJ	MGP_PWKPhJ_G0022147	protein coding gene	Chr17:9745835-9754851 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021977	protein coding gene	Chr17:9952529-9961900 (+)
WSB/EiJ	MGP_WSBEiJ_G0022456	protein coding gene	Chr17:10834489-10844383 (+)

Human Ortholog

TCP1, t-complex 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TCP1, t-complex 1
Synonyms

CCT1, CCTa, CCT-alpha, D6S230E, TCP-1-alpha
Links

HGNC:11655

NCBI Gene ID: 6950

neXtProt AC: NX_P17987

UniProt: P17987
Chr Location

6q25.3; chr6:159778498-159789703 (-) GRCh38

MGI Vertebrate Homology

Tcp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TCP1
Gene Tree

Tcp1

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

43
Endonuclease-mediated

3
Gene trapped

38
Targeted

2
Genomic Mutations

1 involving Tcp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available

There are two electrophoretic alleles known; allele a occurs in all complete t haplotype chromosomes and allele b in wild-type strains. There are multiple changes between the amino acid sequences of the TCP1A and TCP1B proteins encoded by the two alleles.

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All GO Annotations

39
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

25
cDNA Data

39
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tcp1

ZFIN tcp1

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All Sequences

74
RefSeq

4
UniProt

3
CCDS

CCDS28397.1, CCDS70760.1

Ensembl

ENSMUSG00000068039 (Evidence)
NCBI Gene

21454

			Length	Strain/Species	Flank
genomic	21454	NCBI Gene Model \| MGI Sequence Detail	8739	C57BL/6J	± kb
transcript	NM_013686	RefSeq \| MGI Sequence Detail	2499	ZRU/MplStud
polypeptide	P11983	UniProt \| EBI \| MGI Sequence Detail	556	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005149 T-complex protein 1 subunit alpha

(term hierarchy)
InterPro Domains

IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)

IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family

IPR002194 Chaperonin TCP-1, conserved site

IPR027409 GroEL-like apical domain superfamily

IPR027413 GroEL-like equatorial domain superfamily

IPR012715 T-complex protein 1, alpha subunit

IPR027410 TCP-1-like chaperonin intermediate domain superfamily

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All nucleic 67

Genomic 20

cDNA 41

Primer pair 2

Other 4

Microarray probesets 4

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MGD-MRK-13116, MGD-MRK-14810, MGD-MRK-14826, MGD-MRK-15176, MGD-MRK-36524, MGI:107944, MGI:2146890

Summaries

All 108

Developmental Gene Expression 9

Gene Ontology 14

Phenotypes 10
Earliest

J:6159 Silver LM, et al., A major testicular cell protein specified by a mouse T/t complex gene. Cell. 1979 Jun;17(2):275-84
Latest

J:345345 Chen J, et al., Resistance of Acta2(R149C/+) mice to aortic disease is associated with defective release of mutant smooth muscle alpha-actin from the chaperonin-containing TCP1 folding complex. J Biol Chem. 2021 Dec;297(6):101228

TSS for Tcp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142662	Chr17:13135272-13135290 (+)	65 bp
Tssr142663	Chr17:13135313-13135334 (+)	108 bp
Tssr142664	Chr17:13135344-13135362 (+)	137 bp
Tssr142665	Chr17:13135381-13135402 (+)	176 bp
Tssr142666	Chr17:13136159-13136163 (+)	945 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23