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Tcn2 Gene Detail
Summary
  • Symbol
    Tcn2
  • Name
    transcobalamin 2
  • Synonyms
    Tcn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98534
    NCBI Gene: 21452
Location & Maps
more
  • Sequence Map
    Chr11:3917192-3932159 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14968 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.76 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    TCN2, transcobalamin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TCN2, transcobalamin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D22S676, D22S750, II, TC, TC2, TC-2, TCII, TC II
  • Links
    NCBI Gene ID: 6948
    neXtProt AC: NX_P20062

  • Chr Location
    22q12.2; chr22:30607083-30627060 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TCN2 associations

Human Disease Mouse Models
       Transcobalamin II Deficiency   OMIM: 275350
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
This locus controls transcobalamin-2 electrophoretic variation. The s allele determines a slow band in serum from A/J, C57BL/6, BALB/c and C3H/He; the f allele determines faster form in NZB, ST/b and CPB-WV. Heterozygotes have both forms. Sequencing reveals a Gly to Glu substitution in NZB compared to BALB/c, DBA/2 and C57BL/6 (Genbank AF090686).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005043 VEGA Gene Model | MGI Sequence Detail 14968 C57BL/6J ±  kb
transcript OTTMUST00000011220 VEGA | MGI Sequence Detail 2027 Not Applicable  
polypeptide OTTMUSP00000005231 VEGA | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    7 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016197 transcobalamin-2
  • InterPro Domains
    IPR002157 Cobalamin (vitamin B12)-binding transporter, eukaryotic
    IPR027954 Domain of unknown function DUF4430
Molecular
Reagents
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  • All nucleic 390
    cDNA 390

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14807, MGD-MRK-14808, MGI:2144509
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:11946 Frater-Schroder M, et al., Allelic forms of mouse transcobalamin 2. Biochem Genet. 1982 Oct;20(9-10):1001-14
  • Latest
    J:171615 Georgas KM, et al., Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory