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Tcn2
Gene Detail
Symbol

Name
ID
Tcn2
transcobalamin 2
MGI:98534
Synonyms
Tcn-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
2.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr11:3917192-3932159 bp, - strand
From VEGA annotation of GRCm38

  14968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TCN2
Protein SuperFamily: gastric intrinsic factor
Gene Tree: Tcn2

Human
homologs
TCN2, transcobalamin II
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6948
neXtProt AC: NX_P20062

Human Synonyms: D22S676, D22S750, II, TC, TC2, TC-2, TCII, TC II

Human Chr (Location): 22q12.2; chr22:30607083-30627060 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TCN2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
This locus controls transcobalamin-2 electrophoretic variation. The s allele determines a slow band in serum from A/J, C57BL/6, BALB/c and C3H/He; the f allele determines faster form in NZB, ST/b and CPB-WV. Heterozygotes have both forms. Sequencing reveals a Gly to Glu substitution in NZB compared to BALB/c, DBA/2 and C57BL/6 (Genbank AF090686).
 
Interactions
Tcn2 interacts with 82 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cobalamin transport, cobalt ion transport, ...
Component extracellular exosome, extracellular region, ...
Function cobalamin binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (186)    Tissues (166)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
cDNA source data(390)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tcn2 ; ZFIN tcn2    NEW 
Molecular
reagents
All nucleic(390) cDNA(390)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005043 (Evidence)
Ensembl Gene Model ENSMUSG00000020432 (Evidence)
Entrez Gene 21452 (Evidence)
UniGene 20948
DFCI TC1573226, TC1666073, TC1722080
DoTS DT.101168483, DT.101370279, DT.110539487, DT.40161144, DT.537876, DT.94216059, DT.94421615, DT.97363286
NIA Mouse Gene Index U032441
Consensus CDS Project CCDS24371.1
International Mouse Phenotyping Consortium Status Tcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005043 VEGA Gene Model | MGI Sequence Detail 14968 C57BL/6J ±  kb
transcript OTTMUST00000011220 VEGA | MGI Sequence Detail 2027 Not Applicable 
polypeptide OTTMUSP00000005231 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002157 Cobalamin (vitamin B12)-binding transporter, eukaryotic
InterPro IPR019554 Soluble ligand binding domain
Protein Ontology PR:000016197 transcobalamin-2
References
(Earliest) J:11946 Frater-Schroder M, et al., Allelic forms of mouse transcobalamin 2. Biochem Genet. 1982 Oct;20(9-10):1001-14
(Latest) J:171615 Georgas KM, et al., Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
All references(44)
Other
accession IDs
MGD-MRK-14807, MGD-MRK-14808, MGI:2144509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory