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Tcn2
Gene Detail
 Symbol
Name
ID
Tcn2
transcobalamin 2
MGI:98534
Synonyms Tcn-2
Feature Type protein coding gene
Genetic Map
Chromosome 11
2.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr11:3917192-3932159 bp, - strand
From VEGA annotation of GRCm38

  14968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: gastric intrinsic factor
Gene Tree: Tcn2

Human
homologs
Human Homolog TCN2, transcobalamin II
NCBI Gene ID 6948
neXtProt AC  NX_P20062
Human Synonyms  D22S676, D22S750, II, TC, TC2, TC-2, TCII, TC II
Human Chr (Location)  22q12.2; chr22:30607083-30627060 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TCN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls transcobalamin-2 electrophoretic variation. The s allele determines a slow band in serum from A/J, C57BL/6, BALB/c and C3H/He; the f allele determines faster form in NZB, ST/b and CPB-WV. Heterozygotes have both forms. Sequencing reveals a Gly to Glu substitution in NZB compared to BALB/c, DBA/2 and C57BL/6 (Genbank AF090686).
 
Interactions
Tcn2 interacts with 82 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cobalamin metabolic process, cobalamin transport, ...
Component extracellular region, extracellular space, ...
Function cobalamin binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (186)    Tissues (166)    Images (16)
Theiler Stages: 17, 20, 21, 23, 24, 28
Assay TypeResults
RNA in situ 186
cDNA source data(390)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(390) cDNA(390)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005043 (Evidence)
Ensembl Gene ModelENSMUSG00000020432 (Evidence)
Entrez Gene21452 (Evidence)
UniGene20948
DFCITC1573226, TC1666073, TC1722080
DoTSDT.101168483, DT.101370279, DT.110539487, DT.40161144, DT.537876, DT.94216059, DT.94421615, DT.97363286
NIA Mouse Gene IndexU032441
Consensus CDS ProjectCCDS24371.1
International Mouse Knockout Project StatusTcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005043 VEGA Gene Model | MGI Sequence Detail 14968 C57BL/6J ±  kb
transcript OTTMUST00000011220 VEGA | MGI Sequence Detail 2027 Not Applicable 
polypeptide OTTMUSP00000005231 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002157 Cobalamin (vitamin B12)-binding transporter, eukaryotic
InterPro IPR019554 Soluble ligand binding domain
Protein Ontology PR:000016197 transcobalamin-2
References (Earliest) J:11946 Frater-Schroder M, et al., Allelic forms of mouse transcobalamin 2. Biochem Genet. 1982 Oct;20(9-10):1001-14
(Latest) J:171615 Georgas KM, et al., Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
All references(48)
Other
accession IDs
MGD-MRK-14807, MGD-MRK-14808, MGI:2144509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory