Tcn2
Gene Detail

Symbol Name ID

Tcn2 transcobalamin 2 MGI:98534

Synonyms

Tcn-2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

2.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr11:3917192-3932159 bp, - strand From VEGA annotation of GRCm38   14968 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: gastric intrinsic factor
Gene Tree: Tcn2

Human homologs

Human Homolog		TCN2, transcobalamin II
NCBI Gene ID		6948
neXtProt AC		NX_P20062
Human Synonyms		D22S676, D22S750, II, TC, TC2, TC-2, TCII, TC II
Human Chr (Location)		22q12.2; chr22:31003070-31023047 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TCN2

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)
 

This locus controls transcobalamin-2 electrophoretic variation. The s allele determines a slow band in serum from A/J, C57BL/6, BALB/c and C3H/He; the f allele determines faster form in NZB, ST/b and CPB-WV. Heterozygotes have both forms. Sequencing reveals a Gly to Glu substitution in NZB compared to BALB/c, DBA/2 and C57BL/6 (Genbank AF090686).

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cobalamin metabolic process, cobalamin transport, ...
Component	extracellular region, extracellular space
Function	cobalamin binding, metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (186)    Tissues (166)    Images (16)
Theiler Stages: 17, 20, 21, 23, 24, 28

Assay Type	Results
RNA in situ	186

cDNA source data(390)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(390) cDNA(390)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005043 (Evidence)
Ensembl Gene Model	ENSMUSG00000020432 (Evidence)
Entrez Gene	21452 (Evidence)
UniGene	20948
DFCI	TC1573226, TC1666073, TC1722080
DoTS	DT.101168483, DT.101370279, DT.110539487, DT.40161144, DT.537876, DT.94216059, DT.94421615, DT.97363286
NIA Mouse Gene Index	U032441
Consensus CDS Project	CCDS24371.1
International Mouse Knockout Project Status	Tcn2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005043	VEGA Gene Model | MGI Sequence Detail	14968	C57BL/6J
transcript	OTTMUST00000011220	VEGA | MGI Sequence Detail	2027	Not Applicable
polypeptide	OTTMUSP00000005231	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(72) RefSeq(6) UniProt(1)

Polymorphisms

SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002157	Cobalamin (vitamin B12)-binding transporter, eukaryotic
InterPro	IPR019554	Soluble ligand binding domain
Protein Ontology	PR:000016197	transcobalamin-2

References

(Earliest) J:11946 Frater-Schroder M, et al., Allelic forms of mouse transcobalamin 2. Biochem Genet. 1982 Oct;20(9-10):1001-14
(Latest) J:171615 Georgas KM, et al., Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
All references(48)

Other accession IDs

MGD-MRK-14807, MGD-MRK-14808, MGI:2144509