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Ubtf Gene Detail
Summary
  • Symbol
    Ubtf
  • Name
    upstream binding transcription factor, RNA polymerase I
  • Synonyms
    A930005G04Rik, Tcfubf, UBF, UBF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98512
    NCBI Gene: 21429
  • Gene Overview
    MyGene.info: UBTF
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102304560-102319742 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.29 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98512
protein coding gene Chr11:102304560-102320862 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019231
protein coding gene Chr11:105265838-105283342 (-)
A/J MGP_AJ_G0019199
protein coding gene Chr11:100818464-100839869 (-)
AKR/J MGP_AKRJ_G0019168
protein coding gene Chr11:103943925-103960718 (-)
BALB/cJ MGP_BALBcJ_G0019173
protein coding gene Chr11:101309750-101325185 (-)
C3H/HeJ MGP_C3HHeJ_G0018982
protein coding gene Chr11:104150608-104168542 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019622
protein coding gene Chr11:108548559-108566052 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017248
protein coding gene Chr11:98252852-98267913 (-)
CAST/EiJ MGP_CASTEiJ_G0018536
protein coding gene Chr11:105128278-105145883 (-)
CBA/J MGP_CBAJ_G0018951
protein coding gene Chr11:113028359-113050769 (-)
DBA/2J MGP_DBA2J_G0019063
protein coding gene Chr11:100344505-100360070 (-)
FVB/NJ MGP_FVBNJ_G0019053
protein coding gene Chr11:99875406-99891061 (-)
LP/J MGP_LPJ_G0019132
protein coding gene Chr11:105785623-105805720 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019084
protein coding gene Chr11:112530740-112548211 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019660
protein coding gene Chr11:104304577-104321694 (-)
PWK/PhJ MGP_PWKPhJ_G0018299
protein coding gene Chr11:101409328-101425447 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018091
protein coding gene Chr11:104064788-104081016 (-)
WSB/EiJ MGP_WSBEiJ_G0018585
protein coding gene Chr11:104306125-104321389 (-)



Homology
more
  • Human Ortholog
    UBTF, upstream binding transcription factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    UBTF, upstream binding transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CONDBA, NOR-90, UBF, UBF1, UBF-1, UBF2
  • Links
    NCBI Gene ID: 7343
    neXtProt AC: NX_P17480
    UniProt: P17480

  • Chr Location
    17q21.31; chr17:44205033-44221626 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 4 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before implantation with embryonic growth arrest.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020923 Ensembl Gene Model | MGI Sequence Detail 15183 C57BL/6J ±  kb
transcript ENSMUST00000079589 Ensembl | MGI Sequence Detail 3286 Not Applicable  
polypeptide ENSMUSP00000078539 Ensembl | MGI Sequence Detail 764 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 155
    Genomic 4
    cDNA 150
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14765, MGI:1925846
References
more
  • Summaries
    All 69
    Developmental Gene Expression 8
    Gene Ontology 16
    Phenotypes 18
  • Earliest
    J:11433 Hisatake K, et al., Cloning and structural analysis of cDNA and the gene for mouse transcription factor UBF. Nucleic Acids Res. 1991 Sep 11;19(17):4631-7
  • Latest
    J:256998 Toro C, et al., A recurrent de novo missense mutation in UBTF causes developmental neuroregression. Hum Mol Genet. 2018 Feb 15;27(4):691-705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory